7 documents found, page 1 of 1
Phylogeography and invasion history of Aedes aegypti, the Dengue and Zika mosqu...
Salgueiro, P; Serrano, Célia; Gomes, Bruno; Alves, Joana; Sousa, CA; Abecasis, AB; Pinto, JAedes-borne arboviruses have spread globally with outbreaks of vast impact on human populations and health systems. The West African archipelago of Cape Verde had its first outbreak of Dengue in 2009, at the time the largest recorded in Africa, and was one of the few African countries affected by the Zika virus epidemic. Aedes aegypti was the mosquito vector involved in both outbreaks. We performed a phylogeogr...
Down syndrome and microRNAs
Brás, Aldina; Rodrigues, António S; Gomes, Bruno; Rueff, JoseIn recent years numerous studies have indicated the importance of microRNAs (miRNA/miRs) in human pathology. Down syndrome (DS) is the most prevalent survivable chromosomal disorder and is attributed to trisomy 21 and the subsequent alteration of the dosage of genes located on this chromosome. A number of miRNAs are overexpressed in down syndrome, including miR-155, miR-802, miR- 125b-2, let-7c and miR-99a. Thi...
Massive introgression drives species radiation at the range limit of Anopheles ...
Vicente, José L.; Clarkson, Christopher S.; Caputo, Beniamino; Gomes, Bruno; Pombi, Marco; Sousa, Carla A.; Antao, Tiago; DInis, Joaõ; Bottà, GiordanoImpacts of introgressive hybridisation may range from genomic erosion and species collapse to rapid adaptation and speciation but opportunities to study these dynamics are rare. We investigated the extent, causes and consequences of a hybrid zone between Anopheles coluzzii and Anopheles gambiae in Guinea-Bissau, where high hybridisation rates appear to be stable at least since the 1990s. Anopheles gambiae was g...
Geographic population structure of the African malaria vector Anopheles gambiae...
Pinto, João Pedro Soares da Silva; Egyir-Yawson, A.; Vicente, José; Gomes, Bruno; Santolamazza, Federica; Moreno, M.; Charlwood, Jacques DerekThe primary Afrotropical malaria mosquito vector Anopheles gambiae sensu stricto has a complex population structure. In west Africa, this species is split into two molecular forms and displays local and regional variation in chromosomal arrangements and behaviors. To investigate patterns of macrogeographic population substructure, 25 An. gambiae samples from 12 African countries were genotyped at 13 microsatell...
Feeding patterns of molestus and pipiens forms of Culex pipiens (Diptera: Culic...
Gomes, Bruno; Sousa, Carla Alexandra Gama Carrilho da Costa; Vicente, José; Pinho, Leonor; Calderón, Isabel; Arez, ElianeBackground Two biological forms of the mosquito Culex pipiens s.s., denoted pipiens and molestus, display behavioural differences that may affect their role as vectors of arboviruses. In this study, the feeding patterns of molestus and pipiens forms were investigated in Comporta (Portugal), where high levels of inter-form admixture have been recorded. Methods Indoor and outdoor mosquito collections were perform...
Hybridization and population structure of the culex pipiens complex in the isla...
Gomes, Bruno; Alves, Joana; Sousa, Carla A.; Santa-Ana, Marta; Vieira, Inês; Silva, Teresa L.; Almeida, Antó nio P.G.; Donnelly, Martin J.; Pinto, JoãoThe Culex pipiens complex includes two widespread mosquito vector species, Cx. pipiens and Cx. quinquefasciatus. The distribution of these species varies in latitude, with the former being present in temperate regions and the latter in tropical and subtropical regions. However, their distribution range overlaps in certain areas and interspecific hybridization has been documented. Genetic introgression between t...
Asymmetric introgression between sympatric molestus and pipiens forms of Culex ...
Gomes, Bruno; Sousa, Carla A.; Novo, Maria T.; Freitas, Ferdinando B.; Alves, Ricardo; Côrte-Real, Ana R.; Salgueiro, Patrícia; Donnelly, Martin J.Background. Culex pipiens L. is the most widespread mosquito vector in temperate regions. This species consists of two forms, denoted molestus and pipiens, that exhibit important behavioural and physiological differences. The evolutionary relationships and taxonomic status of these forms remain unclear. In northern European latitudes molestus and pipiens populations occupy different habitats (underground vs. ab...