7 documents found, page 1 of 1
High efficacy of chloroquine-derived bile salts in Pluronic F127 micelles again...
Silva, Ana Teresa; Oliveira, Isabel S.; Morais, Inês; Santana, Sofia; Workneh, Eyob A.; Prudêncio, Miguel; Nogueira, Fátima; Ferraz, RicardoFunding Information: The authors thank Funda\u00E7\u00E3o para a Ci\u00EAncia e Tecnologia/Minist\u00E9rio da Educa\u00E7\u00E3o e Ci\u00EAncia \u2013 FCT/MEC, for PT national funds through the project CIRCNA/BRB/0281/2019. FCT/MCE is further acknowledged for supporting the Research Units LAQV-REQUIMTE (LA/P/0008/2020, UIDP/50006/2020 and UIDB/50006/2020), CIQUP (UIDB/00081/2020), IMS (LA/P/0056/2020), and GHTM...
Unlocking the potential of snake venom-based molecules against the malaria, Cha...
Almeida, José Rafael; Gomes, Ana S. M.; Mendes, Bruno; Aguiar, Luísa; Ferreira, Mariana; Brioschi, Mariana Borges Costa; Duarte, DeniseFunding Information: This work received financial support from PT national funds ( FCT/MCTES , Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the project CIRCNA/BRB/0281/2019 . Funding Information: This work received financial support from PT national funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Super...
Corrigendum to
Silva, Ana Teresa; Oliveira, Isabel S.; Gomes, Joana M.; Aguiar, Luísa; Fontinha, Diana; Duarte, Denise Maria Figueiredo Araújo; Nogueira, FátimaScheme 1 and Figure 1 in this article were incorrect. The correct ones, and their respective captions, follow: 1 Scheme (Figure presented.) Synthesis route to PQ-derived organic salts 3a–g. (i) 1a (1 molar equivalent, eq), 2a–g (1 eq), methanol (MeOH), room temperature (RT), 30 min. 1 Figure (Figure presented.) Surface tension plots and cmc determination, at 25 °C, of aqueous CTAB/SAIL mixtures: A) surface tens...
Drug-Derived Surface-Active Ionic Liquids
Silva, Ana Teresa; Oliveira, Isabel S.; Gomes, Joana; Aguiar, Luísa; Fontinha, Diana; Duarte, Denise; Nogueira, Fátima; Prudêncio, MiguelFunding Information: The authors thank Fundação para a Ciência e Tecnologia (FCT, Portugal), for funding Research Units LAQV‐REQUIMTE (UIDB/50006/2020), CIQUP (UIDB/00081/2020), and GHTM (UID/Multi/04413/2013), and for project grant PTDC/BTM‐SAL/29786/2017. ATS thanks FCT and Sociedade Portuguesa de Química (SPQ, Portugal) for her doctoral grant SFRH/BD/150649/2020 Publisher Copyright: © 2021 Wiley-VCH GmbH; In...
Building on surface-active ionic liquids for the rescuing of the antimalarial d...
Silva, Ana Teresa; Lobo, Lis; Oliveira, Isabel S.; Gomes, Joana; Teixeira, Cátia; Nogueira, Fátima; Marques, Eduardo F.; Ferraz, Ricardo; Gomes, PaulaIonic liquids derived from classical antimalarials are emerging as a new approach towards the cost-effective rescuing of those drugs. Herein, we disclose novel surface-active ionic liquids derived from chloroquine and natural fatty acids whose antimalarial activity in vitro was found to be superior to that of the parent drug. The most potent ionic liquid was the laurate salt of chloroquine, which presented IC50...
Coupling the antimalarial cell penetrating peptide TP10 to classical antimalari...
Aguiar, Luísa; Biosca, Arnau; Lantero, Elena; Gut, Jiri; Vale, Nuno; Rosenthal, Philip J.; Nogueira, Fátima; Andreu, David; Fernàndez-Busquets, XavierRecently, we disclosed primaquine cell penetrating peptide conjugates that were more potent than parent primaquine against liver stage Plasmodium parasites and non-toxic to hepatocytes. The same strategy was now applied to the blood-stage antimalarial chloroquine, using a wide set of peptides, including TP10, a cell penetrating peptide with intrinsic antiplasmodial activity. Chloroquine-TP10 conjugates displayi...
11th national meeting of organic chemistry and 4th meeting of therapeutic chemi...
Sousa, Maria Emília; Araújo, Maria João; Do Vale, Maria Luísa; Andrade, Paula B.; Branco, Paula Cristina de Sério; Gomes, Paula; Moreira, RuiThis work received financial support from the European Union (FEDER funds through COMPETE) and National Funds (FCT, Fundação para a Ciência e Tecnologia) through project UID/QUI/50006/2013. Fátima Fernandes (SFRH/BPD/98732/2013) and Mariana Barbosa (SFRH/BD/95861/2013) thank FCT for the grants.; For the first time under the auspices of Sociedade Portuguesa de Química, the competences of two important fields of ...