6 documents found, page 1 of 1
Serum amyloid A proteins reduce bone mass during mycobacterial infections
Gomes, AC; Sousa, DM; Oliveira, TC; Fonseca, O; Pinto, RJ; Silvério, D; Fernandes, AI; Moreira, AC; Silva, T; Teles, MJ; Pereira, L; Saraiva, MIntroductionOsteopenia has been associated to several inflammatory conditions, including mycobacterial infections. How mycobacteria cause bone loss remains elusive, but direct bone infection may not be required. MethodsGenetically engineered mice and morphometric, transcriptomic, and functional analyses were used. Additionally, inflammatory mediators and bone turnover markers were measured in the serum of healt...
Chylothorax in the neonate-A stepwise approach algorithm
Rocha, G; Arnet, V; Soares, P; Gomes, AC; Costa, S; Guerra, P; Casanova, J; Azevedo, IBackground: Chylothorax in neonates results from leakage of lymph from thoracic lymphatic ducts and is mainly congenital or posttraumatic. The clinical course of the effusion is heterogeneous, and consensus on treatment, timing, and modalities of measures has not yet been established. This review aims to present, along with levels of evidence and recommendation grades, all current therapeutic possibilities for ...
H-Ferritin Is Essential for Macrophages' Capacity to Store or Detoxify Exogenou...
Mesquita, G; Silva, T; Gomes, AC; Oliveira, PF; Alves, MG; Fernandes, R; Almeida, AA; Moreira, AC; Gomes, MSMacrophages are central cells both in the immune response and in iron homeostasis. Iron is both essential and potentially toxic. Therefore, iron acquisition, transport, storage, and release are tightly regulated, by several important proteins. Cytosolic ferritin is an iron storage protein composed of 24 subunits of either the L- or the H-type chains. H-ferritin differs from L-ferritin in the capacity to oxidize...
The crossroads between infection and bone loss
Oliveira, TC; Gomes, MS; Gomes, ACBone homeostasis, based on a tight balance between bone formation and bone degradation, is affected by infection. On one hand, some invading pathogens are capable of directly colonizing the bone, leading to its destruction. On the other hand, immune mediators produced in response to infection may dysregulate the deposition of mineral matrix by osteoblasts and/or the resorption of bone by osteoclasts. Therefore,...
Modulation of iron metabolism in response to infection: Twists for all tastes
Gomes, AC; Moreira, AC; Mesquita, G; Gomes, MSIron is an essential nutrient for almost all living organisms, but is not easily made available. Hosts and pathogens engage in a fight for the metal during an infection, leading to major alterations in the host’s iron metabolism. Important pathological consequences can emerge from the mentioned interaction, including anemia. Several recent reports have highlighted the alterations in iron metabolism caused by di...
Rodent models of heart failure: an updated review
Gomes, AC; Falcao Pires, I; Pires, AL; Bras Silva, C; Leite Moreira, AFHeart failure (HF) is one of the major health and economic burdens worldwide, and its prevalence is continuously increasing. The study of HF requires reliable animal models to study the chronic changes and pharmacologic interventions in myocardial structure and function and to follow its progression toward HF. Indeed, during the past 40 years, basic and translational scientists have used small animal models to ...