5 documents found, page 1 of 1
Semi-síntese e avaliação da atividade citotóxica e antimicrobiana de derivados ...
Gomes, Akenaton Onassis Cardoso VianaThe pimarane diterpeno annonalida (11) was isolated from roots of Humirianthera ampla and chemically converted into derivatives ANN-ACET (79), ANN-PROP (80), ANNHEXA (81), ANN-DECA (82) e ANN-Cl (83). Among them, compounds 80-83 are new in the literature. Natural products 16 and 17, and the semisynthetic derivatives 11 were tested in cytotoxicity assays against the human tumor cell lines OVCAR-8 (ovarian), HCT-...
Antifungal activity of palmatine against strains of Candida spp. resistant to a...
Campos, Rosana de Sousa; Silva, Cecília Rocha da; Andrade Neto, João Batista de; Sampaio, Letícia Serpa; Nascimento, Francisca Bruna Stefany Aires doThe incidence of fungal infections has increased and it is necessary to seek new antifungals that also act against resistant strains. Palmatine is a protoberberine alkaloid noteworthy for its various pharmacological properties, including antifungal properties. The objective of this study was to evaluate the activity of palmatine against Candida spp. strains resistant to azole in planktonic cells and biofilm, an...
Screening of antimicrobial metabolite yeast isolates derived biome Ceará agains...
Andrade Neto, João Batista de; Silva, Cecília R. da; Nascimento, Francisca Bruna Stefany Aires do; Sampaio, Letícia Serpa; Silva, Anderson R. daAntimicrobials benefited the history of medicine by revolutionizing the treatment of infectious diseases. However, its consequent and continuous use has led to the emergence of microorganisms which once were considered safe, but have become feared as potentially lethal pathogens (Bowler et al., 2012). Staphylococcus aureus infections are highlighted for being a major cause of systemic infections, and for being ...
Effects of piperonal nitro derivatives on candida species : antifungal activity...
Andrade Neto, João Batista de; Silva, Cecília Rocha da; Campos, Rosana de Sousa; Nascimento, Francisca Bruna Stefany Aires do; Freitas, Daniel DominguesRecently, there has been a significant increase in invasive fungal infections, the treatment of which is limited to a quite small number of antifungal drugs. Natural products represent an important source of antifungal agents, mainly because of their natural coexistence with fungi present in each biome. Derivatives or semi-synthetic products can be used to optimize the pharmacological profile of natural product...
Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole...
Andrade Neto, João Batista de; Silva, Cecília Rocha da; Campos, Rosana de Sousa; Nascimento, Francisca Bruna Stefany Aires do; Sampaio, Letícia SerpaCandida species are the fourth most common cause of nosocomial bloodstream infections in the United States and the fifth to tenth most common causative pathogen in European studies Although C. albicans remains the most common fungal isolate recovered from blood, recent reports indicate a trend towards an increasing prevalence of infections caused by species of Candida other than C. albicans which are associated...