4 documents found, page 1 of 1
Cannabis-Based Products for the Treatment of Skin Inflammatory Diseases: A Time...
Martins, Ana; Gomes, Ana L.; Vilas Boas, Inês; Marto, Joana; Ribeiro, HelenaThe use of natural products in dermatology is increasingly being pursued due to sustainability and ecological issues, and as a possible way to improve the therapeutic outcome of chronic skin diseases, relieving the burden for both patients and healthcare systems. The legalization of cannabis by a growing number of countries has opened the way for researching the use of cannabinoids in therapeutic topical formul...
Correction: Martins et al. Cannabis-Based Products for the Treatment of Skin In...
Martins, Ana; Gomes, Ana L.; Vilas Boas, Inês; Marto, Joana; Ribeiro, Helena
Molecular analysis of c-Kit and PDGFRA in GISTs diagnosed by EUS
Gomes, Ana L.; Bardales, Ricardo H.; Milanezi, Maria Fernanda Grillo; Reis, R. M.; Schmitt, FernandoGastrointestinal stromal tumors (GISTs) are characterized by overexpression and mutations of c-Kit. Approximately 80% of c-Kit mutations occur in exon H, being a response factor to imatinib (Gleevec) therapy. Mutations of platelet-derived growth factor receptor-a (PDGFRA) are observed in a subset of GISTs lacking c-Kit mutations. We aimed to assess whether c-Kit and PDGFRA mutation analysis of GISTs obtained by...
Molecular alterations of KIT oncogene in gliomas
Gomes, Ana L.; Reis-Filho, Jorge S.; Lopes, José M.; Martinho, Olga; Lambros, Maryou B. K.; Martins, Albino; Schmitt, Fernando; Pardal, FernandoGliomas are the most common and devastating primary brain tumours. Despite therapeutic advances, the majority of gliomas do not respond either to chemo or radiotherapy. KIT, a class III receptor tyrosine kinase (RTK), is frequently involved in tumourigenic processes. Currently, KIT constitutes an attractive therapeutic target. In the present study we assessed the frequency of KIT overexpression in gliomas and i...