Purpose of Review: To critically assess the effectiveness of gut microbiota modulation (GMM) as a complementary approach for managing Attention Deficit Hyperactivity Disorder (ADHD) in adults. Methods: A systematic review was conducted following the JBI Manual for Evidence Synthesis, with searches in PubMed, Web of Science, Cochrane Database, ClinicalTrials.gov, EMBASE/Ovid, and APA PsycInfo. Results: Among 3,5...
Cardiovascular disease is the leading cause of death in Portugal and a major contributor to morbidity and disability. With an aging population and increased survival following initial cardiovascular events, the burden of disability-adjusted life years is expected to grow, posing a significant challenge for health systems (Ferreira & Macedo, 2017). In this context, the European Society of Cardiology recommen...
Family reactions to child sexual abuse (CSA) are important, but there is a lack of research on the effect of maternal and paternal reactions on social attributions towards the victim and perpetrator. We conducted an experimental study (N = 549, aged 18-76) using vignettes in which the reactions of the mother or father (blame, denial, or support) were manipulated. Statistically significant differences were found...
This paper focuses on the project developed by a team of students from the University of the Minho in an industrial context. In this context, the definition of a layout is a key factor in the reduction of waste and, consequently, in the increase of productivity. The main objective of this article is to define alternative layout proposals for the new manufacturing facilities of a textile company producing knitte...
This article was developed by a team of students of Industrial Engineering and Management at the University of Minho, using the PBL (Project Based Learning) methodology. The purpose of this article is to define alternative layout proposals for the weaving section of the new factory space of a textile company that produces knitted garments and home textiles. It should be noted that defining a layout is crucial f...
Introdução: Cada vez mais os pais revelam dúvidas, receios e falta de experiência, evidenciando a necessidade sentida pelas grávidas de frequentarem cursos de preparação para a parentalidade, de forma a obterem mais informações sobre a gravidez, a preparação do enxoval, o parto, os cuidados ao recém-nascido e até o envolvimento do pai do bebé e da restante família. Objetivo: Construir e testar a validade de con...
Collateral development in chronic total occlusions (CTO) is crucial to perfuse the distal myocardium and its angiographic evaluation is frequently used to assess the need for revascularization. We aimed to analyse the association between the presence of ischemia and hibernating myocardium, evaluated by cardiac [13 N]NH3/2-[18 F]FDG PET-CT, and the angiographic characterization of the collateral circulation. Pro...
The emergence of novel variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the need to investigate alternative approaches to prevent infection and treat patients with coronavirus disease 2019. Here, we report the preclinical efficacy of NL-CVX1, a de novo decoy that blocks virus entry into cells by binding with nanomolar affinity and high specificity to the receptor-binding doma...
The emergence of novel variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the need to investigate alternative approaches to prevent infection and treat patients with coronavirus disease 2019. Here, we report the preclinical efficacy of NL-CVX1, a de novo decoy that blocks virus entry into cells by binding with nanomolar affinity and high specificity to the receptor-binding doma...
Ovarian cancer is a malignant neoplasm exclusive to females that develops in the ovaries, female sex organs and epithelial ovarian cancer. It has a high mortality rate and is the seventh leading cause of death in women diagnosed with cancer because it develops silently and diagnostic tests have a low predictive value. Thus, developing more accurate diagnostic tests combined with new anti-tumor therapies advance...