3 documents found, page 1 of 1
Secretome of umbilical cord mesenchymal stem cells: Potential effects on melanoma
Fernandes, Pablo ; Gomes, Andreia ; Coelho, PedroMelanoma, a tumor resulting from the malignant transformation of melanocytes, is characterized by its aggressive nature and propensity to metastasize. Current treatment options for advanced melanoma are limited and mostly ineffective, highlighting the need for novel therapeutic approaches. Mesenchymal stem cells (MSCs) have increased considerable attention due to their anti-cancer and immunomodulatory propertie...
Impact of umbilical cord mesenchymal stromal/stem cell secretome and cord blood...
Sousa, André ; Coelho, Pedro; Leite, Fernanda ; Teixeira, Catarina ; Rocha, Ana Catarina ; Santos, Inês ; Baylina, Pilar; Fernandes, RubenProstate cancer (PCa) is the second most common malignancy in men, and the ffth leading cause of death worldwide. Mesenchymal stromal/stem cells (MSC) have been identifed in PCa, although contradictory efects in malignant transformation and tumor progression have been described. Since umbilical cord (UC) MSC and cord blood serum (CBS) are rich in numerous growth and anti-infammatory factors, UC-MSC secretome an...
Human umbilical cord mesenchymal stem cells in type 2 diabetes mellitus: the em...
Gomes, Andreia ; Coelho, Pedro; Soares, Raquel ; Costa, RaquelThe umbilical cord has been proved to be an easy-access, reliable, and useful source of mesenchymal stem cells (MSC) for clinical applications due to its primitive, immunomodulatory, non-immunogenic, secretory and paracrine, migratory, proliferative, and multipotent properties. This set of characteristics has recently attracted great research interest in the fields of nanotechnology and regenerative medicine an...