5 documents found, page 1 of 1
Mitochondrial Sirtuin TcSir2rp3 Affects TcSODA Activity and Oxidative Stress Re...
dos Santos Moura, Leila; Santana Nunes, Vinícius; Gomes, Antoniel A. S. [UNESP]; Sousa, Ana Caroline de Castro Nascimento; Fontes, Marcos R. M. [UNESP]Made available in DSpace on 2022-04-29T08:46:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-11-11; Trypanosoma cruzi faces a variety of environmental scenarios during its life cycle, which include changes in the redox environment that requires a fine regulation of a complex antioxidant arsenal of enzymes. Reversible posttranslational modifications, as lysine acetylation, are a fast and economical way...
The allosteric activation mechanism of a phospholipase A2-like toxin from Bothr...
Gomes, Antoniel A. S. [UNESP]; Cardoso, Fabio F. [UNESP]; Souza, Maximilia F.; Oliveira, Cristiano L. P.; Perahia, David; Magro, Angelo J. [UNESP]Made available in DSpace on 2021-06-25T10:12:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-12-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); The activation process of phospholipase A2-like (PLA2-like) toxins is a key step in their molecular mechanism, which involves oligomeric changes leading to the expos...
Chemical Constituents and Antileishmanial and Antibacterial Activities of Essen...
Oliveira, Daiane M.; Furtado, Fabiana B. [UNESP]; Gomes, Antoniel A. S. [UNESP]; Belut, Belisa R.; Nascimento, Evandro A.; Morais, Sérgio A. L.Made available in DSpace on 2020-12-12T01:54:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-28; Scheelea phalerata Mart. ex Spreng (Arecaceae) is a palm tree found in the Brazilian cerrado. There are no topics related to volatile oils from S. phalerata leaves in the literature. This work determines its chemical composition and evaluates the biological activity under two different seasonal conditio...
Structural basis for phospholipase A2-like toxin inhibition by the synthetic co...
Salvador, Guilherme H. M. [UNESP]; Gomes, Antoniel A. S. [UNESP]; Bryan-Quirós, Wendy; Fernández, Julián; Lewin, Matthew R.; Gutiérrez, José MaríaMade available in DSpace on 2020-12-12T01:05:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-12-01; The World Health Organization recently listed snakebite envenoming as a Neglected Tropical Disease, proposing strategies to significantly reduce the global burden of this complex pathology by 2030. In this context, effective adjuvant treatments to complement conventional antivenom therapy based on inhib...
Structural and functional characterization of suramin-bound MjTX-I from Bothrop...
Salvador, Guilherme H. M. [UNESP]; Dreyer, Thiago R. [UNESP]; Gomes, Antoniel A. S. [UNESP]; Cavalcante, Walter L. G. [UNESP]Made available in DSpace on 2018-12-11T17:37:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-12-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Local myonecrosis is the main event resulting from snakebite envenomation by the Bothrops genus and, frequently, it is not efficiently neutralized by antivenom administration. Proteases, phospholipases A2 (PLA2) and PLA2-like toxins are foun...