4 documents found, page 1 of 1
The involvement of mast cells in the irinotecan-induced enteric neurons loss an...
Nogueira, Ludmila T.; Costa, Deiziane V. S.; Gomes, Antoniella Souza; Martins, Conceição S.; Silva, Angeline M. H. P.; Coelho-Aguiar, Juliana M.Background The irinotecan (CPT-11) causes intestinal mucositis and diarrhea that may be related to changes in the enteric nervous system (ENS). In inflammatory condition, mast cells release a variety of pro-inflammatory mediators that can interact with the ENS cells. It has not been explored whether CPT-11 is able to alter the enteric glial and neuronal cell, and the role of mast cells in this effect. Therefore...
Oral gabapentin treatment accentuates nerve and peripheralinflammatory response...
Câmara, Carlos C.; Ramos, Heitor F.; Silva, Alan P. da; Araújo, Celina V.; Gomes, Antoniella Souza; Vale, Mariana L.; Barbosa, André Luiz R.Gabapentin (GBP) is an anti-convulsive drug often used as analgesic to control neuropathic pain. Thisstudy aimed at evaluating whether oral GBP treatment could improve nerve inflammation response aftersciatic nerve constriction in association with selected pain and motor spontaneous behavior assessmentsin Wistar rats. We evaluated nerve myeloperoxidase (MPO) and inflammatory cytokines on the 5th daypost-injury,...
Efeito protetor do lipopolissacarídeo da Escherichia coli na lesão gástrica por...
Gomes, Antoniella SouzaThe role of the LPS in the defense of the gastric mucosa is still not established. AIMS: 1-To verify the protective effect of the LPS in the gastric damage (GD), in the neutrophil infiltration (NI), in the increase of the leukocyte of adhesion, in the reduction of the induced glutathione levels for indomethacin (INDO) in rats; 2- To investigate the role of the COX-2, NOSi and of ATP-sensitive k channels (KATP) ...
Efeito protetor da via hemeoxigenase 1/ biliverdina/ CO em modelos de lesões gá...
Gomes, Antoniella SouzaTo evaluate the protective effect of the heme-oxygenase 1 (HO-1)/biliverdin/CO pathway in models of gastropathy in mice, evaluating the role of the soluble guanylate cyclase (GCs) and of the constitutive NOS in this event. Methods: Protocol 1: Mice were pre-treated with hemin (HO-1 inducer; 1,3,10 mg/Kg, i.p.), biliverdin (HO-1 product; 1,3 or 10 mg/Kg., i.p.), DMDC (CO donor; 2.5, 7.5, 12.5 or 10 µmol/Kg, i.p....