64 documents found, page 1 of 7
Uncovering the burden of Influenza in children in Portugal, 2008-2018
Caldas Afonso, A; Gouveia, C; Januário, G; Carmo, M; Lopes, H; Bricout, H; Gomes, C; Froes, FBackground Despite their higher risk of developing severe disease, little is known about the burden of influenza in Portugal in children aged < 5 years old. This study aims to cover this gap by estimating the clinical and economic burden of severe influenza in children, in Portugal, during ten consecutive influenza seasons (2008/09-2017/18). Methods We reviewed hospitalizations in children aged < 5 years old us...
Burden and severity of children's hospitalizations by respiratory syncytial vir...
Bandeira, T; Carmo, M; Lopes, H; Gomes, C; Martins, M; Guzman, C; Bangert, M; Rodrigues, F; Januario, G; Tome, T; Azevedo, IBackground Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory infection (ALRI) in young children and is of considerable burden on healthcare systems. Our study aimed to evaluate ALRI hospitalizations related to RSV in children in Portugal. Methods We reviewed hospitalizations potentially related to RSV in children aged <5 years from 2015 to 2018, using anonymized administrative data...
Targeting p53 for melanoma treatment: Counteracting tumour proliferation, disse...
Loureiro, JB; Raimundo, L; Calheiros, J; Carvalho, C; Barcherini, V; Lima, NR; Gomes, C; Almeida, MI; Alves, MG; Costa, JL; Santos, MMM; Saraiva, LMelanoma is the deadliest form of skin cancer, primarily due to its high metastatic propensity and therapeutic resistance in advanced stages. The frequent inactivation of the p53 tumour suppressor protein in melanomagenesis may predict promising outcomes for p53 activators in melanoma therapy. Herein, we aimed to investigate the antitumor potential of the p53-activating agent SLMP53-2 against melanoma. Two-and ...
Apoe variants in an iberian alzheimer cohort detected through an optimized sang...
González, RD; Gomes, I; Gomes, C; Rocha, R; Durães, L; Sousa, P; Figueruelo, M; Rodríguez, M; Pita, C; Hornero, R; Gómez, C; Lopes, AM; Pinto, NThe primary genetic risk factor for late onset Alzheimer’s disease (LOAD) is the APOE4 allele of Apolipoprotein E (APOE) gene. The three most common variants of APOE are determined by single nucleotide polymorphisms (SNPs) rs429358 and rs7412. Our aim was to estimate allele and genotype frequencies of APOE variants in an Iberian cohort, thus helping to understand differences in APOE-related LOAD risk observed a...
A selective p53 activator and anticancer agent to improve colorectal cancer the...
Ramos, H; Soares, MIL; Silva, J; Raimundo, L; Calheiros, J; Gomes, C; Reis, F; Monteiro, FA; Nunes, C; Reis, S; Bosco, B; Piazza, S; Domingues, LImpairment of the p53 pathway is a critical event in cancer. Therefore, reestablishing p53 activity has become one of the most appealing anticancer therapeutic strategies. Here, we disclose the p53-activating anticancer drug (3S)-6,7-bis(hydroxymethyl)-5-methyl-3-phenyl-1H,3H-pyrrolo[1,2-c]thiazole (MANIO). MANIO demonstrates a notable selectivity to the p53 pathway, activating wild-type (WT)p53 and restoring W...
The extracellular small leucine-rich proteoglycan biglycan is a key player in g...
Pinto, F; Santos-Ferreira, L; Pinto, MT; Gomes, C; Reis, CABiglycan (BGN gene), an extracellular proteoglycan, has been described to be associated with cancer aggressiveness. The purpose of this study was to clarify the clinical value of biglycan as a biomarker in multiple independent GC cohorts and determine the in vitro and in vivo role of biglycan in GC malignant features. We found that BGN is commonly over-expressed in all analyzed cohorts, being associated with di...
Complement Decay-Accelerating Factor is a modulator of influenza A virus lung i...
Santos, NB; Silva, ZEV; Gomes, C; Reis, CA; Amorim, MJClearance of viral infections, such as SARS-CoV-2 and influenza A virus (IAV), must be fine-tuned to eliminate the pathogen without causing immunopathology. As such, an aggressive initial innate immune response favors the host in contrast to a detrimental prolonged inflammation. The complement pathway bridges innate and adaptive immune system and contributes to the response by directly clearing pathogens or inf...
Impact of Truncated O-glycans in Gastric-Cancer-Associated CD44v9 Detection
Moreira, IB; Pinto, F; Gomes, C; Campos, D; Reis, CACD44 variant isoforms are often upregulated in cancer and associated with increased aggressive tumor phenotypes. The CD44v9 is one of the major protein splice variant isoforms expressed in human gastrointestinal cancer cells. Immunodetection of CD44 isoforms like CD44v9 in tumor tissue is almost exclusively performed by using specific monoclonal antibodies. However, the structural variability conferred by both ...
Carcinoembryonic antigen carrying SLe X as a new biomarker of more aggressive g...
Gomes, C; Almeida, A; Barreira, A; Calheiros, J; Pinto, F; Abrantes, R; Costa, A; Polónia, A; Campos, D; Osorio, H; Sousa, HS; Pinto-De-Sousa, JMalignant transformation of gastric cells is accompanied by the deregulated expression of glycosyltransferases leading to the biosynthesis of tumor-associated glycans such as the sialyl-Lewis X antigen (SLex). SLex presence on cell surface glycoconjugates increases the invasive capacity of gastric cancer cells and is associated with tumor metastasis. ST3Gal IV enzyme is involved in the synthesis of SLex antigen...
Biotechnology Applied to Cosmetics and Aesthetic Medicines
Gomes, C; Silva, AC; Marques, AC; Lobo, JS; Maria Helena Amaral; Marques AC; Sousa Lobo JMBiotechnology uses microorganisms and/or enzymes to obtain specific products through fermentative processes and/or genetic engineering techniques. Examples of these products are active ingredients, such as hyaluronic acid, kojic acid, resveratrol, and some enzymes, which are used in skin anti-aging products. In addition, certain growth factors, algae, stem cells, and peptides have been included in cosmetics and...