3 documents found, page 1 of 1
Self-Renewal and Pluripotency in Osteosarcoma Stem Cells' Chemoresistance: Notc...
Martins-Neves, Sara R.; Ribeiro, Gabriela Sampaio; Gomes, Célia M. F.Osteosarcoma is a highly malignant bone tumor derived from mesenchymal cells that contains self-renewing cancer stem cells (CSCs), which are responsible for tumor progression and chemotherapy resistance. Understanding the signaling pathways that regulate CSC self-renewal and survival is crucial for developing effective therapies. The Notch, Hedgehog, and Wnt/β-Catenin developmental pathways, which are essential...
Stroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung car...
Rodrigues, Carlos F. D.; Serrano, Eurico; Patrício, Maria I.; Val, Mariana; Albuquerque, Patrícia; Fonseca, João; Gomes, Célia M. F.; Abrunhosa, AnteroCancer stem cells (CSCs) are a small population of resistant cells inhabiting the tumors. Although comprising only nearly 3% of the tumor mass, these cells were demonstrated to orchestrate tumorigenesis and differentiation, underlie tumors' heterogeneity and mediate therapy resistance and tumor relapse. Here we show that CSCs may be formed by dedifferentiation of terminally differentiated tumor cells under stre...
Therapeutic implications of an enriched cancer stem-like cell population in a h...
Martins-Neves, Sara R.; Lopes, Áurio; Carmo, Anália do; Paiva, Artur A.; Simões, Paulo C.; Abrunhosa, Antero; Gomes, Célia M. F.Background: Osteosarcoma is a bone-forming tumor of mesenchymal origin that presents a clinical pattern that is consistent with the cancer stem cell model. Cells with stem-like properties (CSCs) have been identified in several tumors and hypothesized as the responsible for the relative resistance to therapy and tumor relapses. In this study, we aimed to identify and characterize CSCs populations in a human oste...