2 documents found, page 1 of 1
Radiochemical and biological evaluation of novel Sm-153/Ho-166-amino acid-chito...
Marques, F; Gano, L; Batista, MKS; Gomes, CAR; Gomes, P; Santos, ISm-153/Ho-166-chitosan complexes have been considered promising agents for internal radiation therapy. By direct administration, complexes solution converts into a gel, at physiological pH, allowing its retention for a long time. Herein, we report on the synthesis of Sm-153/Ho-166 complexes with the novel amino acid-chitosan polymers, N-(gamma-propanoylvalin)-chitosan (CHICO-val) and N-(gamma-propanoyl-aspartic...
Novel highly-soluble peptide-chitosan polymers: Chemical synthesis and spectral...
Batista, MKS; Pinto, LF; Gomes, CAR; Gomes, PNovel water-soluble polymers, N-(gamma-propanoyl-valin)-chitosan and N-(gamma-propanoyi-aspartic acid)-chitosan, were synthesized by reaction of low molecular weight chitosan with N-alpha-(3-bromopropanoyl)-valine and N-alpha-(3-bromopropanoyl)-aspartic acid, respectively, under mild conditions. Prior to reaction with chitosan, the peptide substituents have been prepared by standard peptide chemistry methods fr...