83 documents found, page 1 of 9

Immunocompetent 3D human CNS Models: a novel approach for preclinical developme...

"Recombinant adeno-associated virus (rAAV) gene therapies hold significant promise for treating central nervous system (CNS) disorders. However, their effectiveness in clinical settings is often limited by the immune responses mounted by the host. Astrocytes and microglia, the resident immune cells of the CNS, play a crucial role in initiating innate immune responses, which can lead to neuroinflammation. Howeve...

Reaction routes with glycidyl methacrylate for the incorporation of oleic acid ...

This research focused on assessing different reaction routes for synthesizing amphiphilic block copolymers, with the hydrophobic part built using glycidyl methacrylate and oleic acid and the hydrophilic segment made from 2(dimethylamino)ethyl methacrylate. The main objectives of this study were to identify reaction routes leading to low-impact branching and/or crosslinking mechanisms involving epoxides and olei...

Effects of microencapsulated phenethyl isothiocyanate on gastrointestinal cance...

Gastrointestinal cancers remain a global health burden, demanding more effective prevention and treatments. Phenethyl isothiocyanate (PEITC), a compound derived from cruciferous vegetables, stands out as a promising nutraceutical agent due to its chemopreventive and therapeutic properties. However, its therapeutic translation remains limited mainly due to its poor water solubility and rapid metabolism. Herein, ...

Scale-up of a sorption process working with molecularly imprinted adsorbents fo...

This work presents the scale-up of a sorption process for the fractionation and enrichment of bioactive compounds in winemaking residues using molecularly imprinted adsorbents. The process works with hydroalcoholic solvents and the improvement of the bioactivity of the produced fractions, comparatively to the raw extracts, is demonstrated. The proposed approach was experimentally validated through the designing...

APOLO-BARI: Effectiveness of a long-term group intervention program after baria...

After bariatric surgery, some individuals may experience long-term weight regain due to problematic eating patterns and the reduced number of post-surgery medical appointments. Therefore, the need for continued monitoring during this period is highlighted. Thus, APOLO-Bari emerges, an intervention developed with the aim of following and monitoring post-surgical results. It became an objective to test its effica...

Immunotherapy in Pediatric Guillain-Barré Syndrome: Intravenous Immunoglobulin,...

Guillain-Barré syndrome (GBS) is an autoimmune disease of the peripheral nervous system that is clinically characterized by rapidly progressing and symmetric muscle weakness, loss (or decrease) of deep tendon reflexes and respiratory distress, leading in some cases to the need for artificial ventilation. This is a clinical diagnosis that can be supported by the integration of several results, coming from cerebr...

Candida albicans chitinase 3 with potential as a vaccine antigen: production, p...

Chitinases are widely studied enzymes that have already found widespread application. Their continued development and valorisation will be driven by the identification of new and improved variants and/or novel applications bringing benefits to industry and society. We previously identified a novel application for chitinases wherein the Candida albicans cell wall surface chitinase 3 (Cht3) was shown to have pote...

Being open, feeling safe and getting creative: The role of team mean openness t...

Although the effects of openness to experience (OTE) on individual creativity are well-established, research on how such effects unfold in a team context is scarce. Drawing on theories of group norms and uncertainty reduction, we argue that team mean OTE leads to a climate of team psychological safety which, in turn, facilitates team creativity. We test our hypothesis over three independent studies, the first c...

Tratamento farmacológico

Tratamento farmacológico