26 documents found, page 1 of 3
The influence of leprosy-related clinical and epidemiological variables in the ...
Cerqueira, Selma Regina Penha Silva; Deps, Patrícia Duarte; Cunha, Débora Vilela; Bezerra, Natanael Victor Furtunato; Barroso, Daniel HolandaBackground Protective effects of Bacillus Calmette–Gue´rin (BCG) vaccination and clofazimine and dapsone treatment against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been reported. Patients at risk for leprosy represent an interesting model for assessing the effects of these therapies on the occurrence and severity of coronavirus disease 2019 (COVID-19). We assessed the influenc...
Sensitivity of different DNA extraction methods and PCR to detect resistance in...
Sevilha-Santos, Lais; Aquino, Danielle Costa; Hans Neto, Günter; Costa, Fabiano José Queiroz; Sousa, Carlos Augusto Felipe de; Morelo, Elaine FariaIntroduction: Antimicrobial resistance in leprosy is an emerging problem, and the quantitative impact of low bacilloscopic indexes (BIs) on the sensitivity of molecular tests is unknown. We aimed to evaluate the sensitivity of gene sequencing for the detection of mutations related to antimicrobial resistance in Mycobacterium leprae in patients with low BIs using an analytical model. Methods: Patients with lepro...
Antimicrobial Resistance among Leprosy Patients in Brazil: Real-World Data Base...
Andrade, Elaine Silva Nascimento; Brandão, Jurema Guerrieri; Silva, Juliana Souza da; Coriolano, Carmelita Ribeiro Filha; Rosa, Patricia SammarcoMinistério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Doenças de Condições Crônicas e Infecções Sexualmente Transmissíveis – DCCI. Coordenação Geral de Doenças em Eliminação – CGDE. Brasília, DF, Brasil / Universidade de Brasilia. Faculdade de Medicina. Programa de Pós-Graduação em Saúde Coletiva. Brasília, DF, Brasil.; Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Do...
Mental health and burnout syndrome among postgraduate students in medical and m...
Pinho, Rebeca da Nóbrega Lucena; Costa, Thais Ferreira; Silva, Nayane Miranda; Barros-Areal, Adriana F.; Salles, André de MattosBackground: The COVID-19 pandemic has led to high levels of physical, psychological, and social stress among health care professionals, including postgraduate students in medical and multidisciplinary residencies. This stress is associated with the intense fear of occupational exposure to SARS-CoV-2, the virus known to cause COVID-19. These professionals are at risk of developing physical and mental illnesses n...
Leprosy detection rate in patients under immunosuppression for the treatment of...
Barroso, Daniel Holanda; Brandão, Jurema Guerrieri; Andrade, Elaine Silva Nascimento; Correia, Ana Clara Banhatto; Aquino, Danielle CostaBackground: Recently developed immunosuppressive drugs, especially TNF antagonists, may enhance the risk of granulomatous infections, including leprosy. We aimed to evaluate the leprosy detection rate in patients under immunosuppression due to rheumatological, dermatological and gastroenterological diseases. Methods: We performed a systematic review of the literature by searching the PubMed, EMBASE, LILACS, Web...
A comprehensive systematic review of leishmaniasis in patients undergoing drug-...
Kurizky, Patricia Shu; Marianelli, Fernanda Ferraço; Cesetti, Mariana Vicente; Damiani, Giovanni; Sampaio, Raimunda Nonata RibeiroImmunosuppression is an important risk factor for leishmaniasis. We assessed the clinical profile, geographic distribution and prevalence of leishmaniasis in patients undergoing immunosuppressive therapy for dermatological, rheumatological or gastroenterological autoimmune diseases. We identified relevant studies in PubMed, EMBASE, Scopus, Web of Science and LILACS on July 3rd, 2018. We included articles that r...
Enhanced il-6 and il-12b gene expression after SARS-CoV-2 infection in leprosy ...
Morais Júnior, Gilberto Santos; Kurizky, Patricia Shu; Cerqueira, Selma Regina Penha Silva; Barroso, Daniel Holanda; Schulte, Heidi LuiseExperts have called attention to the possible negative impact of the coronavirus disease 2019 (COVID19)–related cytokine storm syndrome on the progression of leprosy-related disabilities. We assessed the frequency of reactional states in patients co-infected with Mycobacterium leprae and severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 (SARS-CoV-2). We consecutively included patients during the firs...
Molecular and cellular biomarkers of COVID-19 prognosis : protocol for the pros...
Kurizky, Patricia Shu; Nóbrega, Otávio T.; Soares, Alexandre Anderson de Sousa Munhoz; Aires, Rodrigo Barbosa; Albuquerque, Cleandro Pires deBackground: Since the beginning of the COVID-19 pandemic, the world’s attention has been focused on better understanding the relation between the human host and the SARS-CoV-2 virus, as its action has led to hundreds of thousands of deaths. Objective: In this context, we decided to study certain consequences of the abundant cytokine release over the innate and adaptive immune systems, inflammation, and hemostas...
Enhanced il-6 and il-12b gene expression after SARS-CoV-2 infection in leprosy ...
Morais Júnior, Gilberto Santos; Kurizky, Patricia Shu; Cerqueira, Selma Regina Penha Silva; Barroso, Daniel Holanda; Schulte, Heidi LuiseExperts have called attention to the possible negative impact of the coronavirus disease 2019 (COVID-19)–related cytokine storm syndrome on the progression of leprosy-related disabilities. We assessed the frequency of reactional states in patients co-infected with Mycobacterium leprae and severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 (SARS-CoV-2). We consecutively included patients during the fir...
SARS-CoV-2/DENV co-infection : a series of cases from the Federal District, Mid...
Schulte, Heidi Luise; Sousa, José Diego Brito; Lacerda, Marcus Vinícius Guimarães de; Naves, Luciana Ansaneli; Gois, Eliana Teles deBackground: Since the novel coronavirus disease outbreak, over 179.7 million people have been infected by SARS-CoV-2 worldwide, including the population living in dengue-endemic regions, particularly Latin America and Southeast Asia, raising concern about the impact of possible co-infections. Methods: Thirteen SARS-CoV-2/DENV co-infection cases reported in Midwestern Brazil between April and September of 2020 a...