Encontrados 35 documentos, a visualizar página 1 de 4
Adverse Drug Reactions and Potentially Inappropriate Medication in Older Patien...
Gomes, Daniela; Herdeiro, Maria; Ribeiro-Vaz, Inês; Ferreira, Pedro; Roque, FátimaCriteria have been developed to identify potentially inappropriate medications that can enhance adverse reactions, highly prevalent in older patient's therapy. This study aimed to identify potentially inappropriate medications within the adverse drug reactions reported in the Portuguese pharmacovigilance system, characterizing the reports where inappropriate medications were identified. INFARMED, I.P. provided ...
Baby-Led weaning como método de alimentação complementar: revisão de literatura
Gomes, Daniela; Festas, ConstançaEnquadramento: As experiênciasnutricionais durante a infância e os primeiros anos de vida podem influenciar odesenvolvimento de hábitos alimentares saudáveis. O Baby-Led Weaning (BLW) é ummétodo alternativo de alimentação complementar em que as crianças comemsozinhas, com as mãos, alimentos moídos, picados ou em forma de finger foods.Surgiu como uma alternativa ao método tradicional de alimentação complementare...
De novo curcuminoids production in engineered Escherichia coli
Rodrigues, Joana Lúcia Lima Correia; Antas, Carolina; Gomes, Daniela; Rodrigues, L. R.Curcuminoids are a mixture of polyphenolic compounds (curcumin, bisdemethoxycurcumin and demethoxycurcumin) produced in the plant Curcuma longa with several therapeutic properties, including anticancer, anti-inflammatory, among others. Given this great potential, the curcuminoids market size is expected to reach $369M by 2033 with 11.3% CAGR [1]. However, these compounds are present in low amounts, accumulate d...
Perspectives on the design of microbial cell factories to produce prenylflavonoids
Gomes, Daniela; Rodrigues, L. R.; Rodrigues, Joana Lúcia Lima CorreiaPrenylflavonoids are flavonoid-derived compounds characterized by the presence of a lipophilic prenylated side-chain in the flavonoid skeleton. These compounds are present in several food supplements and food products, and have a wide variety of recognized biological activities, namely estrogenic, antioxidant, anti-inflammatory and anticancer. Since these compounds are present in nature in very low amounts, the...
Yeast synthetic biology approaches for the production of valuable polyphenolic ...
Gomes, Daniela; Costa, João Manuel Rainha; Rodrigues, L. R.; Rodrigues, Joana Lúcia Lima CorreiaPolyphenols are secondary metabolites isolated from plants that are known for their biological and therapeutical properties. However, the extraction from plants renders low yields, besides being expensive and not environmentally friendly. Therefore, the use of heterologous microorganisms, so-called microbial chassis, became an interesting alternative approach to produce polyphenols. With the advances in the met...
The Rurtugal Project: from translation/localization to multilingual digital pro...
Araújo, Sílvia; Gomes, DanielaOur paper introduces the Rurtugal project, which is a joint venture from students of two curricular units of the Master’s Degree in Multilingual Translation and Communication: Art History and Multilingual Digital Localization and Production. This is a project for the promotion of Portuguese villages, whose main objective is to engage students in entrepreneurship and social responsibility, based on an initiative...
Zymomonas mobilis as an emerging biotechnological chassis for the production of...
Braga, Adelaide; Gomes, Daniela; Costa, João Manuel Rainha; Amorim, Cláudia; Cardoso, Beatriz; Gudiña, Eduardo José; Silvério, Sara Isabel CruzZymomonas mobilis is a well-recognized ethanologenic bacterium with outstanding characteristics which make it a promising platform for the biotechnological production of relevant building blocks and fine chemicals compounds. In the last years, research has been focused on the physiological, genetic, and metabolic engineering strategies aiming at expanding Z. mobilis ability to metabolize lignocellulosic substra...
Synthetic biology approaches to engineer polyphenols microbial cell factories
Rodrigues, Lígia M.; Gomes, Daniela; Costa, João Manuel Rainha; Rodrigues, Joana Lúcia Lima CorreiaPolyphenols are secondary metabolites isolated from plants that can be divided into flavonoids, stilbenoids, curcuminoids, coumarins, polyphenolic amides and lignans. These exhibit diverse biological and potential therapeutic activities including antioxidant, anti-inflammatory and anticancer, among others. Despite all this potential, extracting polyphenols from plants is not straightforward given the low yields...
Engineering Zymomonas mobilis to produce tailor-made fructooligosaccharides
Braga, Adelaide; Gomes, Daniela; Amorim, Cláudia; Cardoso, B.; Silvério, Sara Isabel Cruz; Rodrigues, Joana Lúcia Lima Correia; Rodrigues, L. R.[Excerpt] Background: Fructooligosaccharides (FOS) are promising prebiotics in the increasing market of functional food. Industrially, these compounds are produced from sucrose using fructosyltransferase (Ftase) or β-fructofuranosidase enzymes (Ffase) [1]. Although it is known that these compounds may have a great impact in health, it has also been described that the beneficial effects may depend on the relativ...
Zymomonas mobilis: a promising microorganism for prebiotic production
Braga, Adelaide; Gomes, Daniela; Rainha, João; Amorim, Cláudia Catarina Oliveira; Cardoso, B.; Gudiña, Eduardo José; Silvério, Sara Isabel CruzZymomonas mobilis (ZM) is an ethanologenic bacterium with outstanding characteristics which makes it an interesting chassis for the biotechnological production of prebiotics. Fructooligosaccharides (FOS) are promising prebiotics in the increasing market of functional food. In this work, a Box-Behnken design approach was used to optimize the medium composition and maximize the FOS content. Under optimal conditio...