8 documents found, page 1 of 1
Glial-restricted precursors stimulate endogenous cytogenesis and effectively re...
Martins-Macedo, Joana; Araújo, Bruna; Anjo, Sandra I.; Silveira-Rosa, Tiago; Patrício, Patrícia; Alves, Nuno Dinis; Silva, Joana M.; Teixeira, Fábio G.Adult cytogenesis, the continuous generation of newly-born neurons (neurogenesis) and glial cells (gliogenesis) throughout life, is highly impaired in several neuropsychiatric disorders, such as Major Depressive Disorder (MDD), impacting negatively on cognitive and emotional domains. Despite playing a critical role in brain homeostasis, the importance of gliogenesis has been overlooked, both in healthy and dise...
Pre-clinical assessment of Roflumilast therapy in a thoracic model of spinal co...
Sousa, Carla S.; Lima, Rui Augusto Ribeiro; Cibrão, Jorge R.; Gomes, Eduardo D.; Fernandes, Luís S.; Pinho, Tiffany Santos; Silva, DeolindaThe failure of axons to regenerate after a spinal cord injury (SCI) remains one of the greatest challenges in neuroscience. The initial mechanical trauma is followed by a secondary injury cascade, creating a hostile microenvironment, which not only is not permissive to regeneration but also leads to further damage. One of the most promising approaches for promoting axonal regeneration is to maintain the levels ...
StressMatic: a novel automated system to induce depressive- and anxiety-like ph...
Martins-Macedo, Joana; Mateus-Pinheiro, António; Alves, Cátia; Veloso, Fernando José Silva; Gomes, Eduardo D.; Ribeiro, Inês; Correia, Joana S.Major depressive disorder (MDD) is a multidimensional psychiatric disorder that is estimated to affect around 350 million people worldwide. Generating valid and effective animal models of depression is critical and has been challenging for neuroscience researchers. For preclinical studies, models based on stress exposure, such as unpredictable chronic mild stress (uCMS), are amongst the most reliable and used, ...
Neuroinflammation and Parkinson’s disease—from neurodegeneration to therapeutic...
Araújo, Bruna; Caridade-Silva, Rita; Soares-Guedes, Carla; Martins-Macedo, Joana; Gomes, Eduardo D.; Monteiro, Susana; Teixeira, Fábio G.Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder world wide. Clinically, it is characterized by a progressive degeneration of dopaminergic neurons (DAn), resulting in severe motor complications. Preclinical and clinical studies have indicated that neuroin flammation can play a role in PD pathophysiology, being associated with its onset and progression. Nevertheless, several key p...
Immunomodulatory and regenerative effects of the full and fractioned adipose ti...
Pinho, Andreia G.; Cibrão, Jorge R.; Lima, Rui; Gomes, Eduardo D.; Serra, Sofia C.; Lentilhas-Graça, José; Ribeiro, Clarisse; Lanceros-Méndez, S.Adipose tissue derived stem cells (ASCs) are recognized to secret a myriad of molecules (secretome) know to modulate inflammatory response, promote axonal growth as well vascular remodeling and cellular survival. In previous works we have reported the benefit effects of ASCs transplanted to the injury site in a rat model of spinal cord injury (SCI). Emerging evidence have shown that the therapeutic actions of t...
Co-Transplantation of Adipose Tissue-Derived Stromal Cells and Olfactory Enshea...
Gomes, Eduardo D.; Mendes, Sofia Silva; Silva, Rita Catarina Assunção Ribeiro; Teixeira, Fábio Gabriel Rodrigues; Pires, Ana O.; Anjo, Sandra I.Patients suffering from spinal cord injury (SCI) still have a dismal prognosis. Despite all the efforts developed in this area, currently there are no effective treatments. Therefore, cell therapies have been proposed as a viable alternative to the current treatments used. Adipose tissue-derived stromal cells (ASCs) and olfactory ensheathing cells (OECs) have been used with promising results in different models...
Impact of mesenchymal stem cells' secretome on glioblastoma pathophysiology
Vieira de Castro, Joana; Gomes, Eduardo D.; Granja, Sara; Anjo, Sandra I.; Baltazar, Fátima; Manadas, Bruno; Salgado, António J.; Costa, Bruno M.Background: Glioblastoma (GBM) is a highly aggressive primary brain cancer, for which curative therapies are not available. An emerging therapeutic approach suggested to have potential to target malignant gliomas has been based on the use of multipotent mesenchymal stem cells (MSCs), either unmodified or engineered to deliver anticancer therapeutic agents, as these cells present an intrinsic capacity to migrate...
Combination of a peptide-modified gellan gum hydrogel with cell therapy in a lu...
Gomes, Eduardo D.; Mendes, Sofia Silva; Leite-Almeida, Hugo; Gimble, Jeffrey M.; Tam, Roger Y.; Shoichet, Molly S.; Sousa, NunoSpinal Cord Injury (SCI) is a highly incapacitating condition for which there is still no cure. Current clinical approaches are mainly based on palliative care, so there is a need to find possible treatments to SCI. Cellular transplantation is regarded with great expectation due to the therapeutic potential of cells such as Adipose tissue-derived Stromal/Stem Cells (ASCs) or Olfactory Ensheathing Cells (OECs). ...