39 documents found, page 1 of 4

NEXTSTEP - Developing future smart secondary substations

Secular Trends in the Mortality by Cerebrovascular Diseases in Portugal: 1902-2012

Introduction: Cerebrovascular diseases (CVD) are one of the main causes of death in Portugal. Research on the epidemiologic history might help to understand the phenomenon and guide intervention strategies. Objectives: (1) Describe historic trends in mortality. (2) Estimate the impact of demographic variations on the registered number of cases. Methods: (1) We calculated rates, specific and standardized, for de...

Diversidade e inclusão no CHULC, sabia que… na consulta de pedopsiquiatria no H...

Nocardia Cyriacigeorgica and Aspergillus Co-Infection in a Patient with Giant-C...

Immunosuppressed patients are at greater risk of unusual infections. The authors present the case of a woman with giant-cell arteritis, on oral steroids, who developed cavitating pneumonia due to co-infection with Aspergillus and Nocardia. Reports of such co-infection are rare in the literature. This case highlights the importance of considering rare pathogens in immunosuppressed patients who present with non-s...

Phenolic plant extracts versus penicillin G: In vitro susceptibility of Staphyl...

Antibiotics are the elective drugs in bovine mastitis (BM) treatment, despite their low rates of efficiency and effectiveness and increasing risk of pathogen resistance. In this sense, it is urgent to discover new and effective antimicrobial agents to apply in BM control and even treatment. Plant extracts have been widely recognized as a rich source of phytochemicals with antimicrobial potential. Thus, the pres...

Anti-biofilm activity of hydromethanolic plant extracts against Staphylococcus ...

Bovine mastitis (BM)presents a high incidence, being Staphylococcus aureus one of the major causative agents. Antibiotics comprise the most common therapeutic approach, but due to their indiscriminate use, high rates of increasingly resistant bacterial species have been markedly pointed out. Particularly, S. aureus possesses a pronounced ability to form biofilms, and therefore, are of pivotal interest due to it...

Non-Uremic Calciphylaxis: a Rare Diagnosis with Limited Therapeutic Strategies

Calciphylaxis is a rare condition characterized by the emergence of non-healing skin ulcers secondary to arterial calcification and thrombosis, typically diagnosed in patients with end-stage kidney disease (ESKD). When it develops in patients without ESKD, it is called non-uremic calciphylaxis (NUC). The latter is an even rarer diagnosis with an uncertain pathophysiology and a high mortality rate (52%), mainly ...

Targeting DNA Damage in SCLC

SCLC accounts for 15% of lung cancer worldwide. Characterised by early dissemination and rapid development of chemo-resistant disease, less than 5% of patients survive 5 years. Despite 3 decades of clinical trials there has been no change to the standard platinum and etoposide regimen for first line treatment developed in the 1970's. The exceptionally high number of genomic aberrations observed in SCLC combined...

Sarcoma de Kaposi oral

O sarcoma de Kaposi é a neoplasia maligna mais frequente nos doentes seropositivos para o vírus da imunodeficiência humana, com envolvimento da cavidade orofaríngea num quarto dos doentes. Descreve-se o caso de uma doente com infeção pelo vírus da imunodeficiência humana, que se apresenta com uma massa vascularizada na base da língua, como primeira manifestação de sarcoma de Kaposi.

Abordagem Diagnóstica e Terapêutica da Diabetes Mellitus no Doente com Infeção ...

A terapêutica antirretroviral levou a uma redução significativa da morbi e mortalidade nos doentes infetados pelo vírus da imunodeficiência humana. No entanto, as complicações cardiometabólicas do tratamento e o envelhecimento desta população têm alargado a complexidade de cuidados para a gestão de comorbilidades cardiovasculares. O aumento da insulinorresistência e da prevalência da diabetes mellitus tipo 2 ne...