3 documents found, page 1 of 1
GABAergic transmission and modulation of anxiety: a review on molecular aspects
Gomes, Francisco Isaac Fernandes; Aragão, Maria Gerusa Brito; Bezerra, Mirna Marques; Chaves, Hellíada VasconcelosStress responses activate protective mechanisms to achieve homeostasis, but they can be detrimental when such responses become maladaptive. Anxiety relates to risk assessment of a potential threat and involves uncertainty regarding the anticipation of a threatening situation and it dampers quality of life. Gamma-Aminobutyric Acid (GABA) is the major inhibitory system in the central nervous system and plays a ke...
Heme oxygenase-1/biliverdin/carbon monoxide pathway downregulates hypernocicept...
Chaves, Hellíada Vasconcelos; Val, Danielle Rocha do; Ribeiro, Kátia Alves; Lemos, Jonas Cavalcante; Souza, Ricardo BastoCHAVES, Hellíada Vasconcelos; Objective and design To investigate the role of heme oxygenase-1 (HO-1), carbon monoxide (CO), and biliverdin (BVD) in the zymosan-induced TMJ arthritis in rats. Materials and Methods Mechanical threshold was assessed before and 4 h after TMJ arthritis induction in rats. Cell influx, myeloperoxidase activity, and histological changes were measured in the TMJ lavages and tissues. Tr...
Anti-inflammatory and anti-nociceptive effects of strontium ranelate on the zym...
Alves, Sheila Moreira; Abreu, Susana Capistrano; Lemos, Jonas Cavalcante; Gomes, Francisco Isaac Fernandes; Alves, Shirley MoreiraBackground Temporomandibular joint (TMJ) disorders show inflammatory components, heavily impacting on quality of life. Strontium ranelate has previously shown anti-inflammatory and antinociceptive effects on other experimental inflammatory pain models. Thus, we aim to investigate the strontium ranelate efficacy in reducing the zymosan-induced inflammatory hypernociception in the TMJ of rats by evaluating the TN...