7 documents found, page 1 of 1
Oxytocin and social isolation: Nonapeptide regulation of social homeostasis
Kareklas, Kyriacos; Oliveira, Rui F.Social isolation imposes physiological and behavioural effects that can have a severe impact on health, but the underlying mechanisms remain poorly understood. We reason that mechanisms responsible for the motivation to interact with others and the cognitive assessment of social interactions also mediate the effects of the lack of social interactions. This is because social isolation stress depends on the abili...
Emotional contagion and prosocial behaviour in fish: An evolutionary and mechan...
Kareklas, Kyriacos; Oliveira, Rui F.In this review, we consider the definitions and experimental approaches to emotional contagion and prosocial behaviour in mammals and explore their evolutionary conceptualisation for studying their occurrence in the evolutionarily divergent vertebrate group of ray-finned fish. We present evidence for a diverse set of fish phenotypes that meet definitional criteria for prosocial behaviour and emotional contagion...
Autism-associated gene shank3 is necessary for social contagion in zebrafish
Kareklas, Kyriacos; Teles, Magda C; Dreosti, Elena; Oliveira, Rui F.Background Animal models enable targeting autism-associated genes, such as the shank3 gene, to assess their impact on behavioural phenotypes. However, this is often limited to simple behaviours relevant for social interaction. Social contagion is a complex phenotype forming the basis of human empathic behaviour and involves attention to the behaviour of others for recognizing and sharing their emotional or affe...
Social and asocial learning in zebrafish are encoded by a shared brain network ...
Pinho, Adriano Bastos; Cunliffe, Vincent; Kareklas, Kyriacos; Petri, Giovanni; Oliveira, Rui F.Group living animals use social and asocial cues to predict the presence of reward or punishment in the environment through associative learning. The degree to which social and asocial learning share the same mechanisms is still a matter of debate. We have used a classical conditioning paradigm in zebrafish, in which a social (fish image) or an asocial (circle image) conditioned stimulus (CS) have been paired w...
Evolutionarily conserved role of oxytocin in social fear contagion in zebrafish
Akinrinade, Ibukun; Kareklas, Kyriacos; Teles, Magda C; Reis, Thais K.; Gliksberg, Michael; Petri, Giovanni; Levkowitz, Gil; Oliveira, Rui F.Emotional contagion is the most ancestral form of empathy. We tested to what extent the proximate mechanisms of emotional contagion are evolutionarily conserved by assessing the role of oxytocin, known to regulate empathic behaviors in mammals, in social fear contagion in zebrafish. Using oxytocin and oxytocin receptor mutants, we show that oxytocin is both necessary and sufficient for observer zebrafish to imi...
Social zebrafish: Danio rerio as an emerging model in social neuroendocrinology
Kareklas, Kyriacos; Teles, Magda C; Nunes, Ana Rita; F. Oliveira, RuiThe fitness benefits of social life depend on the ability of animals to affiliate with others and form groups, on dominance hierarchies within groups that determine resource distribution, and on cognitive capacities for recognition, learning and information transfer. The evolution of these phenotypes is coupled with that of neuroendocrine mechanisms, but the causal link between the two remains underexplored. Gr...
Phenotypic architecture of sociality and its associated genetic polymorphisms i...
Gonçalves, Claúdia; Kareklas, Kyriacos; Teles, Magda C; Varela, Susana.A.M.; Costa, João; Leite, Ricardo B.; Paixão, Tiago; Oliveira, Rui FilipeSociality relies on motivational and cognitive components that may have evolved independently, or may have been linked by phenotypic correlations driven by a shared selective pressure for increased social competence. Furthermore, these components may be domain-specific or of general-domain across social and non-social contexts. Here, we used zebrafish to test if the motivational and cognitive components of soci...