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3D bioactive ionic liquid-based architectures: an anti-inflammatory approach fo...
Gomes, Joana M.; Marques, Ana Catarina Fernandes; Rodrigues, Luísa Cidália Guimarães; Silva, Tiago H.; Silva, Simone S.; Reis, R. L.3D bioprinting enables the fabrication of biomimetic cell-laden constructs for cartilage regeneration, of- fering exclusive strategies for precise pharmacological screenings in osteoarthritis (OA). Synovial inflam- mation plays a crucial role in OAâ s early stage and progression, characterized by the increased of the syn- ovial pro-inflammatory mediators and cytokines and chondrocyte apoptosis. Therefore, there...
Chitosan-based hierarchical scaffolds crosslinked with genipin
Piaia, Lya; Silva, Simone S.; Fernandes, Emanuel Mouta; Gomes, Joana M.; Franco, Albina Ribeiro; Leonor, I. B.; Fredel, Márcio C.; Salmoria, Gean V.Osteochondral defects present significant challenges for effective tissue regeneration due to the complex composition of bone and cartilage. To address this challenge, this study presents the fabrication of hierarchical scaffolds combining chitosan/β-tricalcium phosphate (β-TCP) to simulate a bone-like layer, interconnected with a silk fibroin layer to mimic cartilage, thus replicating the cartilage-like laye...
Development of bilayered porous silk scaffolds for thymus bioengineering
Silva, Catarina S.; Kundu, Banani; Gomes, Joana M.; Fernandes, Emanuel Mouta; Reis, R. L.; Kundu, Subhas C; Martins, Albino; Neves, N. M.The thymus coordinates the development and selection of T cells. It is structured into two main compartments: the cortex and the medulla. The replication of such complex 3D environment has been challenged by bioengineering approaches. Nevertheless, the effect of the scaffold microstructure on thymic epithelial cell (TEC) cultures has not been deeply investigated. Here, we developed bilayered porous silk fibroi...
Alginate/acemannan-based beads loaded with a biocompatible ionic liquid as a bi...
Gomes, Joana M.; Silva, SS; Rodrigues, Luísa Cidália Guimarães; Reis, R. L.Combining biomacromolecules with green chemistry principles and clean technologies has proven to be an effective approach for drug delivery, providing a prolonged and sustained release of the encapsulated material. The current study investigates the potential of cholinium caffeate (Ch[Caffeate]), a phenolic-based biocompatible ionic liquid (Bio-IL) entrapped in alginate/acemannan beads, as a drug delivery syste...
Tunable silk matrices using ionic liquids and their biomedical applications
Silva, Simone S.; Gomes, Joana M.; Kundu, Subhas C; Reis, R. L.Silk fibroin (SF) is a well-known natural protein with considerable potential to develop high-value materials for biomedical applications due to its intrinsic features, such as availability, versatility, and biocompatibility. In recent investigations, ionic liquids (ILs) have attracted attention as green solvents for tuning SF-based biomaterials. Like traditional solvents, ILs can be used as a solvent to proces...
Chitosan/β-TCP composites scaffolds coated with silk fibroin: a bone tissue eng...
Piaia, Lya; Silva, Simone S.; Gomes, Joana M.; Franco, Albina Ribeiro; Fernandes, Emanuel Mouta; Lobo, Flávia Cristina Marques; Rodrigues, Luísa C.Bone regeneration and natural repair are long-standing processes that can lead to uneven new tissue growth. By introducing scaffolds that can be autografts and/or allografts, tissue engineering provides new approaches to manage the major burdens involved in this process. Polymeric scaffolds allow the incorporation of bioactive agents that improve their biological and mechanical performance, making them suitable...
Tailoring natural-based oleogels combining ethylcellulose and virgin coconut oil
Silva, Simone S.; Rodrigues, Luísa C.; Fernandes, Emanuel M.; Lobo, Flávia C. M.; Gomes, Joana M.; Reis, R. L.Oleogels are becoming an attractive research field, since they have recently been shown to be feasible for the food and pharmaceutical sectors and provided some insights into the biomedical area. In this work, edible oleogels were tailored through the combination of ethylcellulose (EC), a gelling agent, with virgin coconut oil (VCO), vegetable oil derived from coconut. The influence of the different EC and VCO ...
Green solvents combined with bioactive compounds as delivery systems: present s...
Silva, Simone S.; Gomes, Joana M.; Reis, R. L.; Kundu, Subhas CGreen solvents such as ionic liquids (ILs) unlock possibilities for developing innovative biomedical and pharmaceutical solutions. ILs are the most investigated solvents for compound extractions, as reaction media and/or catalysts, and a desired eco-friendly solvent to process biomacromolecules for biomaterial production. Investigations demonstrate that the tunable nature and physicochemical features of ILs are...
Biomedical exploitation of chitin and chitosan-based matrices via ionic liquid ...
Silva, Siimone S.; Gomes, Joana M.; Rodrigues, Luísa C.; Reis, R. L.Chitin and chitosan are well-known biopolymers, and they have been considered a sustainable feedstock for biomedical applications. However, the highly ordered structure and strong hydrogen bonding network of those polymers can be a limiting factor for their application, in particular for chitin, which is insoluble in conventional solvents. Therefore certain ionic liquids can dissolve and process both chitin and...
Biocompatible ionic liquids: fundamental behaviours and applications
Gomes, Joana M.; Silva, Simone S.; Reis, R. L.Biocompatible ionic liquids (Bio-ILs) are an eco- and bio-friendly family of ionic liquids (ILs) useful in applications ranging from the electrochemical to the biomedical fields. The most promising strategies for their synthesis involve using molecules from bio-renewable sources as a basis for both the anionic and cationic counterparts of the Bio-ILs structure. Several studies have been conducted on Bio-IL prop...