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Preclinical evidences for an antimanic effect of carvedilol

Souza, Greicy Coelho de; Gomes, Julia Ariana de S.; Queiroz, Ana Isabelle de Góis; Araújo, Maíra Morais de; Cavalcante, Lígia Menezes

Oxidative imbalance, alterations in brain-derived neurotrophic factor (BDNF), and mitochondrial dysfunction are implicated in bipolar disorder (BD) pathophysiology and comorbidities, for example, cardiovascular conditions. Carvedilol (CVD), a nonselective beta-blocker widely used for the treatment of hypertension, presents antioxidant and mitochondrial stabilizing properties. Thus, we hypothesized that CVD woul...

Date: 2016   |   Origin: Oasisbr
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