17 documents found, page 1 of 2
Diagnosis and management of acromegaly: a consensus statement of the pituitary ...
Cardoso, Luís Miguel; Marques, Pedro; Pereira, Maria Teresa; Agapito, Ana; Almeida, Rui; Amaral, Sara; Cattoni, Maria Begona; Bugalho, Maria JoãoAcromegaly is characterised by hypersecretion of growth hormone and presents diagnostic and therapeutic challenges that require consensus and guidelines for effective management. The Pituitary Study Group of the Portuguese Society of Endocrinology, Diabetes and Metabolism used a modified Delphi methodology to develop consensus recommendations for the diagnosis and management of acromegaly. A multidisciplinary p...
The hemodynamic response function as a type 2 diabetes biomarker: a data-driven...
Guimarães, Pedro; Serranho, Pedro; Duarte, João V.; Crisóstomo, Joana; Moreno, Carolina; Gomes, Leonor; Bernardes, Rui; Castelo-Branco, MiguelIntroduction: There is a need to better understand the neurophysiological changes associated with early brain dysfunction in Type 2 diabetes mellitus (T2DM) before vascular or structural lesions. Our aim was to use a novel unbiased data-driven approach to detect and characterize hemodynamic response function (HRF) alterations in T2DM patients, focusing on their potential as biomarkers. Methods: We meshed task-b...
Regular physical activity moderates the adverse impact of type 2 diabetes on br...
Moreno, Carolina; d'Almeida, Otília C.; Gomes, Leonor; Paiva, Isabel; Castelo-Branco, MiguelObjective: Brain atrophy has been consistently associated with type 2 diabetes, beginning in early stages of dysglycemia, independently from micro and macrovascular complications. On the contrary, physical activity relates with larger brain volumes. Our aim is to assess the influence of regular physical activity on brain volumes in people with type 2 diabetes. Methods: A cross-sectional multimodal evaluation wi...
Changes in hemodynamic response function components reveal specific changes in ...
Duarte, João V.; Guerra, Catarina; Moreno, Carolina; Gomes, Leonor; Castelo-Branco, MiguelType 2 Diabetes Mellitus (T2DM) is a metabolic disease that leads to multiple vascular complications with concomitant changes in human neurophysiology, which may lead to long-term cognitive impairment, and dementia. Early impairments of neurovascular coupling can be studied using event-related functional magnetic resonance imaging (fMRI) designs. Here, we aimed to characterize the changes in the hemodynamic res...
Maturity-Onset Diabetes of the Young (MODY) in Portugal: Novel GCK, HNFA1 and H...
Alvelos, Maria I.; Gonçalves, Catarina I.; Coutinho, Eduarda; Almeida, Joana T.; Bastos, Margarida; Sampaio, Maria L.; Melo, Miguel; Martins, SofiaMaturity-onset diabetes of the young (MODY) is a frequently misdiagnosed type of diabetes, which is characterized by early onset, autosomal dominant inheritance, and absence of insulin dependence. The most frequent subtypes are due to mutations of the GCK (MODY 2), HNF1A (MODY 3), and HNF4A (MODY 1) genes. We undertook the first multicenter genetic study of MODY in the Portuguese population. The GCK, HNF1A, and...
The neurometabolic profiles of GABA and Glutamate as revealed by proton magneti...
d'Almeida, Otília C.; Violante, Inês R.; Quendera, Bruno; Moreno, Carolina; Gomes, Leonor; Castelo-Branco, MiguelGlucose metabolism is pivotal for energy and neurotransmitter synthesis and homeostasis, particularly in Glutamate and GABA systems. In turn, the stringent control of inhibitory/excitatory tonus is known to be relevant in neuropsychiatric conditions. Glutamatergic neurotransmission dominates excitatory synaptic functions and is involved in plasticity and excitotoxicity. GABAergic neurochemistry underlies inhibi...
Caracterização do perfil de ácidos gordos de alimentos consumidos pela populaçã...
Gomes, Leonor; Fontes, Tânia; Vilarinho, Fernanda; Tavares, Nelson; Santos, Mariana; Castanheira, IsabelIntrodução: De acordo com o estudo Global Burden of Disease (GBD) realizado em 2017, os hábitos alimentares inadequados dos portugueses foram o terceiro fator de risco que mais contribuiu para a perda de anos de vida saudável. Na última década, diversos estudos epidemiológicos têm evidenciado uma relação entre a saúde e o consumo de certos tipos de gordura, nomeadamente pela ingestão de alguns ácidos gordos esp...
Impacto do Uso Prolongado da Terapêutica Subcutânea Contínua com Insulina no Co...
Azevedo, Sérgio; Saraiva, Joana; Caramelo, Francisco; Fadiga, Lúcia; Barros, Luisa; Baptista, Carla; Melo, Miguel; Gomes, Leonor; Carrilho, FranciscoIntrodução: O uso da terapêutica com perfusão subcutânea contínua de insulina na diabetes mellitus tipo 1 é cada vez mais frequente devido aos seus efeitos benéficos no controlo glicémico e na flexibilidade do estilo de vida. Constituiu objetivo deste estudo avaliar o impacto da terapêutica com perfusão subcutânea contínua de insulina no controlo glicémico, índice de massa corporal, dose diária total de insulin...
The Impact of Prolonged Use of Continuous Subcutaneous Insulin Infusion in the ...
Azevedo, Sérgio; Saraiva, Joana; Caramelo, Francisco; Fadiga, Lúcia; Barros, Luísa; Baptista, Carla; Melo, Miguel; Gomes, Leonor; Carrilho, FranciscoIntroduction: The use of continuous subcutaneous insulin infusion therapy in type 1 diabetes mellitus has increased due to its benefits on glycemic control and on the lifestyle flexibility. The aim of this study was to assess the impact of continuous subcutaneous insulin infusion therapy on glycemic control, body mass index, total daily dose of insulin and complications associated with this therapy, during 20 y...
Relations between Cardiac and Visual Phenotypes in Diabetes: A Multivariate App...
Oliveiros, Bárbara; Sanches, Mafalda; Quendera, Bruno; Graça, Bruno; Guelho, Daniela; Gomes, Leonor; Carrilho, Francisco; Alves, Filipe CaseiroCardiovascular disease and diabetes represent a major public health concern. The former is the most frequent cause of death and disability in patients with type 2 diabetes, where left ventricular dysfunction is highly prevalent. Moreover, diabetic retinopathy is becoming a dominant cause of visual impairment and blindness. The complex relation between cardiovascular disease and diabetic retinopathy as a functio...