50 documents found, page 1 of 5
Effects of methanolic and aqueous extracts of Carica papaya leaf on miRNA-media...
Jacques, Filipa; Delgadinho, Mariana; Ginete, Catarina; Gomes, Mário; Ribeiro, Edna; Brito, Miguel; Gomes, Anita Q.Introduction: Hemoglobinopathies are genetic blood disorders characterized by abnormal hemoglobin that disrupts oxygen transport and leads to diverse health complications. Raising fetal hemoglobin (HbF) levels is one possible therapeutic approach. But the current main therapy based on the use of hydroxyurea (HU), faces limitations related to cost and safety, especially in underserved areas. To overcome these co...
Modulação da expressão de microRNAs em células humanas K562 induzida por extrat...
Edna; Ribeiro, Edna; Canteiro , Beatriz; Ginete , Catarina; Gomes, Mário; Brito, Miguel; Gomes, Anita; Silva, CarinaIntrodução – As hemoglobinopatias constituem um dos grupos de doenças monogénicas mais prevalentes a nível mundial. Atualmente, um dos tratamentos disponíveis consiste na indução farmacológica da hemoglobina fetal (HbF) através de vários compostos químicos, sendo o mais comum a hidroxiureia (HU). Contudo, o seu custo elevado em países subdesenvolvidos e o seu perfil de segurança limitam a utilização deste compo...
Artificial Intelligence-Driven User Interaction with Smart Homes: Architecture ...
Lemos, João; Ramos, João; Gomes, Mário; Coelho, PauloThe evolution of Smart Grids enabled the deployment of intelligent and decentralized energy management solutions at the residential level. This work presents a comprehensive Smart Home architecture that integrates real-time energy monitoring, appliance-level consumption analysis, and environmental data acquisition using smart metering technologies and distributed IoT sensors. All collected data are structured i...
Analysis of the biological effect of Carica papaya leaf extracts on the viabili...
Canteiro, Beatriz; Mendes, Maria; Delgadinho, Mariana; Oliveira, Ketlyn; Ginete, Catarina; Gomes, Mário; Ribeiro, Edna; Brito, Miguel; Gomes, AnitaBackground – Sickle cell disease (SCD) is a genetic blood disorder caused by mutations in the β-globin gene that affects the shape and transport of red blood cells in blood vessels, leading to various clinical complications. The pharmacological reactivation of fetal hemoglobin (HbF) through compounds such as hydroxyurea (HU), is one of the currently available treatments, however, their safety concerns and expen...
Espaços exteriores nos jardins de infância - estudo, conceção e desenvolvimento...
Gomes, MárioO presente relatório de estágio reporta sobre os trabalhos realizados em âmbito de estágio na empresa Nautilus, cuja prática versou, sobretudo, sobre o desenho de equipamento profissional e organização de espaços expositivos. No final do estágio tivemos a oportunidade de desenvolver um projeto individual cujo tema incidiu sobre os espaços exteriores nos jardins de infância. Considerando que esta é uma problemát...
Wastewater Electrolysis for Hydrogen Production
Cartaxo, Marco; Fernandes, José; Gomes, Mário; Pinho, Henrique J. O.; Nunes, Valentim; Coelho, PauloDue to its highest gravimetric energy density, H2 has been regarded as the preferred clean-energy carrier, with potentially environmentally-friendly production through the solar-assisted WS. Since human activities generate enormous amounts of WW, H2 production from this new resource has gained attention as an emergent technology. This paper addresses the most relevant and current aspects of H2 production from W...
Effects of Quercetin in transcriptional and post-transcriptional regulation of ...
Canteiro, Beatriz; Mendes, Maria; Jacques, Filipa; Delgadinho, Mariana; Oliveira, Ketlyn; Ginete, Catarina; Gomes, Mário; Ribeiro, Edna; Brito, MiguelHemoglobinopathies are a group of inherited blood disorders that primarily affect red blood cells. The most common type is known as sickle cell anemia (SCA). It is characterized by mutations in the HBB gene, which encodes the β-subunit of human hemoglobin, giving rise to hemoglobin S (HbS). When deoxygenated, HbS polymerizes in the red blood cell, giving it a sickle shape and making it rigid and fragile. Fetal ...
Effects of quercetin in transcriptional and post-transcriptional regulation of ...
Canteiro, Beatriz; Mendes, Maria; Jacques, Filipa; Delgadinho, Mariana; Oliveira, Ketlyn; Ginete, Catarina; Gomes, Mário; Ribeiro, Edna; Brito, MiguelSickle Cell anemia (SCA) is a hereditary hemoglobinopathy with the formation of hemoglobin S, associated with severe health outcomes. Currently, induction of fetal hemoglobin (HbF) is one of the most promising therapeutic strategies. Here we aimed to assess the potential of the natural compound Quercetin, in transcriptional expression of globin and HbF regulatory/silencing genes. In this study, the K562 cell li...
Análise do efeito biológico de extratos de folhas de Carica papaya na viabilida...
Canteiro, Beatriz; Mendes, Maria; Delgadinho, Mariana; Oliveira, Ketlyn; Ginete, Catarina; Gomes, Mário; Ribeiro, Edna; Brito, Miguel; Gomes, Anita Q.Introdução – A anemia falciforme é uma doença monogénica causada por mutações no gene da β-globina que afeta a estrutura da hemoglobina, sendo associada a diversas complicações clínicas com elevadas taxas de morbilidade e mortalidade. A reativação farmacológica da hemoglobina fetal (HbF) por compostos como a hidroxiureia (HU) é um dos tratamentos atualmente disponíveis; contudo, o seu perfil de segurança e o el...
Effect of carbamylated erythropoietin in a chronic model of TNBS-induced colitis
Silva, Inês; Gomes, Mário; Alípio, Carolina; Vitoriano, Jéssica; Estarreja, João; Mendes, Priscila; Pinto, Rui; Mateus, VanessaBackground: Inflammatory bowel disease (IBD) is a public health issue with a growing prevalence, which can be divided into two phenotypes, namely Crohn's disease (CD) and ulcerative colitis (UC). Currently, used therapy is based only on symptomatic and/or palliative pharmacological approaches. These treatments seek to induce and maintain remission of the disease and ameliorate its secondary effects; however, th...