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Experimental investigation of cellular steel beams at ambient and elevated temp...
Vidoti da Silva, Luana; Giacomitti, Nickolas; Ferreira, Débora; Lopes, Nuno; Mesquita, Luís M.R.Cellular steel beams, commonly used in modern construction, exhibit complex failure mechanisms that have not been thoroughly explored, especially under fire conditions. This research investigates the structural behaviour of cellular beams under both ambient and elevated temperatures, with a focus on load-bearing capacity and failure modes. Experimental tests were conducted on a solid beam and six cellular beams...
Os maus tratos contra crianças no contexto familiar
Ferreira, DéboraO presente Relatório de Estágio, intitulado “Os Maus Tratos Contra Crianças no Contexto Familiar: o retrato de um CAFAP na Área Metropolitana do Porto” foi realizado no âmbito do Mestrado em Intervenção Social na Infância e Juventude em Risco de Exclusão Social, tendo como objetivo analisar e compreender a presença e dimensão da problemática dos maus tratos no contexto de um Centro de Apoio Familiar e Aconselha...
Influence of puncture devices on the accuracy of cyclophosphamide dosing for ch...
Carvalho, Susana; Cardoso, Andreia; Ferreira, Débora; Silva, Diana Dias da; Moreira, Fernando; Moreira, Fernando; Dias da Silva, Diana CristinaCyclophosphamide is one of the most commonly used cytotoxic drugs in chemotherapy protocols. Its preparation in the hospital setting involves handling concentrated solutions, which pose occupational exposure risks and potential variations in the final dose administered. The aim of this study was to evaluate the effect of aspiration devices on the concentration of cyclophosphamide in reconstituted solutions. An ...
Evaluation and characterization of the built rural environment of the Montesinh...
Luso, Eduarda; Ferreira, DéboraIn Portugal, in recent decades, there has been an increase in the population and cities located on the coast and, on the contrary, a decrease in inland locations, with greater severity in rural areas. The causes are complex and not consensual, but it is clear that factors such as the lack of investment in the interior, emigration and migration to a coast that is increasingly autistic in its relationship with th...
Evaluating the fire behaviour of cement-based lightweight materials with textil...
Magalhães, Leandro; Conde, Otávio Sateles; Mesquita, L.M.R.; Briga-Sá, Ana; Ferreira, DéboraThe conscientious utilization of natural resources and the efficient waste management have become a matter of great concern in recent years due to the harmful impacts on the environment. The construction sector presents itself as one of the sectors that most contributes to raw materials consumption and waste generation, demanding the investigation of more sustainable and ecofriendly building materials, where th...
Enhancing concrete sustainability with spent diatomaceous earth from the wine i...
Magalhães, Leandro; Ferreira, Débora; Ramos‐Gavilán, Ana BelénSpent diatomaceous earth, a by-product of wine filtration, holds significant promise for use in concrete mixtures due to its pozzolanic properties, which enhance concrete performance. This research explores the application of spent calcined diatomaceous earth (SCDE), heat-treated at 700 C to remove organic content, as a partial substitute for cement or sand in concrete. The high silica content of SCDE contribut...
Controlo de qualidade de soluções de ciclofosfamida preparadas com agulha ou co...
Carvalho, Susana; Cardoso, Andreia; Ferreira, Débora; Moreira, Fernando; Moreira, FernandoA utilização de agulhas para aspiração de fármacos citotóxicos aumenta o risco de exposição ocupacional dos profissionais de farmácia que os preparam, sendo por isso frequentemente substituída por dispositivos de libertação de pressão designados de spikes. Um dos fármacos antineoplásicos mais habitualmente manipulados em preparações de quimioterapia é a ciclofosfamida. Os objetivos deste estudo são: (i) validar...
Aptamer-based therapy for fighting biofilm-associated infections
Sousa, Ana Margarida; Ferreira, Débora; Rodrigues, L. R.; Pereira, Maria OlíviaBiofilms are key players in the pathogenesis of most of chronic infections associated with host tissue or fluids and indwelling medical devices. These chronic infections are hard to be treated due to the increased biofilms tolerance towards antibiotics in comparison to planktonic (or free living) cells. Despite the advanced understanding of their formation and physiology, biofilms continue to be a challenge and...
Potential of exosome-mediated delivery of CRISPR-Cas9 for microRNA-155 targetin...
Gonçalves, Catarina Augusta Silva; Rodrigues, L. R.; Ferreira, DéboraBreast cancer comprises a critical issue for public healthcare, with triple negative breast cancer (TNBC) being the most aggressive subtype, characterized by the lack of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). Standard treatments such as surgical therapy, chemotherapy, and radiotherapy, are invasive and lack selectivity. Hence, exploring novel targ...
Exploring lactoferrin-loaded exosomes as a novel therapeutic strategy for color...
Novo, Inês C.; Pereira, Cátia S.; Rodrigues, L. R.; Ferreira, DéboraColorectal cancer (CRC) is characterized by the uncontrolled proliferation of abnormal cells in the lining of colon or rectum. Primary treatment modalities against CRC include surgical intervention and chemotherapy, which often fail. Hence, there is a pressing need for innovative targeted therapies. Bovine lactoferrin (bLf), a natural milk-derived protein, has shown selective cytotoxicity against CRC cells. How...