7 documents found, page 1 of 1
Glutaraldehyde-crosslinking chitosan scaffolds reinforced with calcium phosphat...
Pinto, Rosana V.; Gomes, Pedro S.; Fernandes, Maria H.; Costa, Maria E.V.; Almeida, Maria M.The clinical demand for bone scaffolds as an alternative strategy for bone grafting has increased exponentially and, up to date, numerous formulations have been proposed to regenerate the bone tissue. However, most of these structures lack at least one of the fundamental/ideal properties of these materials (e.g., mechanical resistance, interconnected porosity, bioactivity, biodegradability, etc.). In this work,...
Understanding intracellular trafficking and anti-inflammatory effects of minocy...
Martin, Victor; Ribeiro, Isabel A. C.; Alves, Marta M.; Gonçalves, Lídia; Almeida, António José; Grenho, Liliana; Fernandes, Maria H.Periodontal diseases remain a challenge due to a complex interplay of factors involving a chronic inflammatory activation and bacteria internalization in periodontal cells. In this work, chitosan-nanoparticles loaded with minocycline (MH-NPs), a tetracycline with antimicrobial and anti-inflammatory effects, were developed for in situ delivery in the periodontal milieu aiming to improve drug effectiveness. A gen...
PDMS-SiO2-TiO2-CaO hybrid materials - Cytocompatibility and nanoscale surface f...
Carlos Almeida, J.; Wacha, Andras; Gomes, Pedro S.; Fernandes, M. Helena R.; Helena Vaz Fernandes, M.; Miranda Salvado, Isabel M.Two PDMS-SiO2-TiO2-Cao porous hybrid materials were prepared using the same base composition, precursors, and solvents, but following two different sol-gel procedures, based on the authors' previous works where for the first time, in this hybrid system, calcium acetate was used as calcium source. The two different procedures resulted in monolithic materials with different structures, microstructures, and surfac...
A biocompatible hybrid material with simultaneous calcium and strontium release...
Almeida, J. Carlos; Wacha, András; Gomes, Pedro S.; Alves, Luís C.; Fernandes, M. Helena Vaz; Salvado, Isabel M. Miranda; Fernandes, M. Helena R.The increasing interest in the effect of strontiumin bone tissue repair has promoted the development of bioactive materialswith strontiumrelease capability. According to literature, hybrid materials based on the systemPDMS SiO2 have been considered a plausible alternative as they present a mechanical behavior similar to the one of the human bone. The main purpose of this study was to obtain a biocompatible hybr...
A biocompatible hybrid material with simultaneous calcium and strontium release...
Carlos Almeida, J.; Wacha, Andras; Gomes, Pedro S.; Alves, Luis C.; Helena Vaz Fernandes, M.; Miranda Salvado, Isabel M.; Fernandes, M. Helena R.The increasing interest in the effect of strontium in bone tissue repair has promoted the development of bioactive materials with strontium release capability. According to literature, hybrid materials based on the system PDMS-SiO2 have been considered a plausible alternative as they present a mechanical behavior similar to the one of the human bone. The main purpose of this study was to obtain a biocompatible ...
Toward the definition of a peptidome signature and protease profile in chronic ...
Trindade, Fabio; Amado, Francisco; Oliveira-Silva, Rui P.; Daniel-da-Silva, Ana L.; Ferreira, Rita; Klein, Julie; Faria-Almeida, RicardoPurpose Chronic periodontitis (CP) is a complex immuno-inflammatory disease that results from preestablished gingivitis. We investigated potential differences in salivary peptidome in health and CP. Experimental design Saliva was collected from nine CP patients and ten healthy subjects, from which five CP and five healthy were enriched following endoProteoFASP approach, separated and identified by nanoHPLC-MALD...
Smart electroconductive bioactive ceramics to promote in situ electrostimulatio...
Mata, Diogo; Oliveira, Filipe J.; Neto, Miguel A.; Belmonte, Manuel; Bastos, Alexandre C.; Lopes, Maria A.; Gomes, Pedro S.; Fernandes, Maria H.Biomaterials can still be reinvented to become simple and universal bone regeneration solutions. Following this roadmap, conductive CNT-based \"smart\" materials accumulate exciting grafting qualities for tuning the in vitro cellular phenotype. Biphasic electrical stimulation of human osteoblastic cells was performed in vitro on either dielectric bioactive bone grafts or conductive CNT-reinforced composites. Th...