8 documents found, page 1 of 1

E-NTPDase-2 de Leishmania amazonensis é importante na adesão do parasito ao mac...

Programa de Pós-Graduação em Ciências Biológicas. Núcleo de Pesquisas em Ciências Biológicas, Pró-Reitoria de Pesquisa de Pós Graduação, Universidade Federal de Ouro Preto.; As NTPDases (nucleosídeo trisfosfato difosfohidrolases) são enzimas com a habilidade de hidrolisar nucleotídeos di e trifosfatados sob estímulo de íons bivalentes (Ca2+ ou Mg2+). São encontradas em diversos tipos celulares, incluindo protoz...

E-NTPDase (ecto-nucleoside triphosphate diphosphohydrolase) of Leishmania amazo...

Leishmania amazonensis, the causal agent of diffuse cutaneous leishmaniasis, is known for its ability to modulate the host immune response. Because a relationship between ectonucleotidase activity and the ability of Leishmania to generate injury in C57BL/6 mice has been demonstrated, in this study we evaluated the involvement of ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) activity of L. amazonen...

The Antileishmanial Potential of C-3 Functionalized Isobenzofuranones against L...

Leishmaniases are diseases caused by protozoan parasites of the genus Leishmania. Clinically, leishmaniases range from cutaneous to visceral forms, with estimated global incidences of 1.2 and 0.4 million cases per year, respectively. The treatment of these diseases relies on multiple parenteral injections with pentavalent antimonials or amphotericin B. However, these pharmaceuticals are either too toxic or expe...

Leishmania infantum ecto-nucleoside triphosphate diphosphohydrolase-2 is an apy...

Visceral leishmaniasis is an important tropical disease, and Leishmania infantum chagasi (synonym of Leishmania infantum) is the main pathogenic agent of visceral leishmaniasis in the New World. Recently, ecto-nucleoside triphosphate diphosphohydrolases (E-NTPDases) were identified as enablers of infection and virulence factors in many pathogens. Two putative E-NTPDases (∼70 kDa and ∼45 kDa) have been found in ...

Medicamentos anti-hipertensivos utilizados na área rural de Ouro Preto, MG.

E-NTPDase (ecto-nucleoside triphosphate diphosphohydrolase) of Leishmania amazo...

Leishmania amazonensis, the causal agent of diffuse cutaneous leishmaniasis, is known for its ability to modulate the host immune response. Because a relationship between ectonucleotidase activity and the ability of Leishmania to generate injury in C57BL/6 mice has been demonstrated, in this study we evaluated the involvement of ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) activity of L. amazonen...

The influence of ecto-nucleotidases on Leishmania amazonensis infection and imm...

Previous results from our laboratory and from the literature have implicated the expression of ectonucleotidases in the establishment of Leishmania infection. In the present study we evaluated the correlation between ecto-nucleotidasic activity and the infectivity of L. amazonensis promastigotes that were kept in culture for short or extended numbers of passages, a condition that is known to decrease parasite i...

Ecto-nucleotidase activities of promastigotes from leishmania (Viannia) brazili...

Background: Leishmania (Viannia) braziliensis has been associated with a broad range of clinical manifestations ranging from a simple cutaneous ulcer to destructive mucosal lesions. Factors leading to this diversity of clinical presentations are not clear, but parasite factors have lately been recognized as important in determining disease progression. Given the fact that the activity of ecto-nucleotidases corr...