Encontrados 7 documentos, a visualizar página 1 de 1
Genetic ablation of inositol 1,4,5-Trisphosphate receptor type 2 (IP3R2) fails ...
Garcia, Daniela Raquel Cunha; Fernandes, Daniela Monteiro; Correia, Joana Sofia; Carvalho, Andreia Alexandra NevesSpinocerebellar ataxia type 3 (SCA3) is a rare neurodegenerative disease caused by an abnormal polyglutamine expansion within the ataxin-3 protein (ATXN3). This leads to neurodegeneration of specific brain and spinal cord regions, resulting in a progressive loss of motor function. Despite neuronal death, non-neuronal cells, including astrocytes, are also involved in SCA3 pathogenesis. Astrogliosis is a common p...
The impact of astrocyte calcium signaling in cortico-limbic function and behavior
Gomes, Sónia Isabel Nunes GuerraOs astrócitos desempenham múltiplas funções desde a homeostasia cerebral ao controlo e processamento da atividade sináptica. Eles integram sinais neuronais por elevações complexas de cálcio (Ca2+) com impacto na comunicação neurónio-astrócito. As elevações de Ca2+ nos astrócitos podem ser divididas em dois tipos: globais (presentes no soma e principais processos) e/ou focais (presentes nos microdomínios). Apesa...
Functional Roles of Astrocyte Calcium Elevations: From Synapses to Behavior
Gomes, Sónia Isabel Nunes Guerra; Sousa, Nuno; Pinto, Luísa; Oliveira, João F.Astrocytes are fundamental players in the regulation of synaptic transmission and plasticity. They display unique morphological and phenotypical features that allow to monitor and to dynamically respond to changes. One of the hallmarks of the astrocytic response is the generation of calcium elevations, which further affect downstream cellular processes. Technical advances in the field have allowed to spatially ...
The role of astrocytic calcium signaling in the aged prefrontal cortex
Gomes, Sónia Isabel Nunes Guerra; Viana, João Filipe; Nascimento, Diana Sofia Marques; Correia, Joana Sofia Silva; Sardinha, Vanessa Alexandra MoraisAging is a lifelong process characterized by cognitive decline putatively due to structural and functional changes of neural circuits of the brain. Neuron-glial signaling is a fundamental component of structure and function of circuits of the brain, and yet its possible role in aging remains elusive. Significantly, neuron-glial networks of the prefrontal cortex undergo age-related alterations that can affect co...
Astrocytic signaling supports hippocampal-prefrontal theta synchronization and ...
Sardinha, Vanessa Alexandra Morais; Gomes, Sónia Isabel Nunes Guerra; Campos, Inês Caetano Costa; Tavares, Gabriela Pires; Martins, Manuella MendesAstrocytes interact with neurons at the cellular level through modulation of synaptic formation, maturation, and function, but the impact of such interaction into behavior remains unclear. Here, we studied the dominant negative SNARE (dnSNARE) mouse model to dissect the role of astrocyte-derived signaling in corticolimbic circuits, with implications for cognitive processing. We found that the blockade of gliotr...
Employing an open-source tool to assess astrocyte tridimensional structure
Tavares, Gabriela Pires; Martins, Manuella Mendes; Correia, Joana Sofia Silva; Sardinha, Vanessa Alexandra Morais; Gomes, Sónia Isabel Nunes GuerraAstrocytes display important features that allow them to maintain a close dialog with neurons, ultimately impacting brain function. The complex morphological structure of astrocytes is crucial to the role of astrocytes in brain networks. Therefore, assessing morphologic features of astrocytes will help provide insights into their physiological relevance in healthy and pathological conditions. Currently availabl...
Do stars govern our actions? astrocyte involvement in rodent behavior
Oliveira, João F.; Sardinha, Vanessa Morais; Gomes, Sónia Isabel Nunes Guerra; Araque, Alfonso; Sousa, NunoAstrocytes have emerged as important partners of neurons in information processing. Important progress has been made in the past two decades in understanding the role of astrocytes in the generation of neuron–astrocyte network outputs resulting in behavior. We review evidence for astrocyte involvement across four different behavioral domains: cognition, emotion, motor, and sensory processing. Accumulating evide...