As Novas Técnicas Genómicas (NGTs) são técnicas desenvolvidas a partir de 2001, após a adoção da legislação sobre organismos gene ticamente modificados (OGM). Estas incluem a mutagénese dirigida, cisgénese, intragénese e transgénese. As NGTs permitem mutações genómicas precisas num organismo, podendo faze lo sem inserção de material genético estranho (mutagénese dirigida); ou com a inserção de material genético...
Cardiovascular diseases are the main cause of death in the world and cardiovascular imaging techniques are the mainstay of noninvasive diagnosis. Aortic stenosis is a lethal cardiac disease preceded by aortic valve calcification for several years. Data-driven tools developed with Deep Learning (DL) algorithms can process and categorize medical images data, providing fast diagnoses with considered reliability, t...
Background: As one of the most important food production sectors worldwide, aquaculture is now invested in developing tools to study fish immunity. Fish health relies heavily on hematopoietic organs (head kidney), but also on intestine. The wide knowledge-gap of the fish immune system coupled with the lack of cell lines to perform in vitro studies poses a barrier to the development of efficient tools to enhance...
Background: Microplastics (MPs) in seafood are a global major concern to human health [1]. Due to MPs’ ubiquitous presence in aquatic ecosystems, aquacultures are also susceptible to contamination from external or endogenous sources. Previous studies have reported MP occurrence in farmed organisms [2], but little is known about recirculating aquaculture systems (RAS), which provide an opportunity for sustainabl...
The well being of temporary workers is still understudied, especially the role of individual resources as promoters of well being. As such, t his paper aims to examine the role of resilience as a resource for enhancing work engagement and reducing burnout of temporary agency workers. Additionally, thi s study tests the mediating role of work alienation. The study follows a quantitative approach. Based on a samp...
The diagnosis of many heart diseases involves the analysis of images from Computed Tomography (CT) or echocardiography, which is mainly done by a medical professional. By using Deep Learning (DL) algorithms, it is possible to create a data-driven tool capable of processing and classifying this type of image, to support physicians in their tasks, improving healthcare efficiency by offering faster and more accura...
Growing evidence suggests the implication of brain plasticity in antidepressant drug (AD) efficacy. Several authors have been pointing out the role of the BDNF-TrkB signaling pathway, including the downstream kinases Akt and ERK, and the mTOR pathway in neuroplasticity [1-3]. Furthermore, the prediction of AD response phenotypes of depressed patients treated with AD drugs remains a challenge for clinicians. Alt...
Made available in DSpace on 2021-06-25T15:07:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-12-01; Fac Ciencias Med Santa Casa Sao Paulo, Sao Paulo, Brazil; Hosp Restauracao, Recife, PE, Brazil; Hosp Univ Getulio Vargas, Manaus, Amazonas, Brazil; Hosp Israelita Albert Einstein, Sao Paulo, Brazil; Hosp Clin Sao Paulo, FMUSP, Sao Paulo, Brazil; Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil; Hosp Sant...
Made available in DSpace on 2021-06-25T15:07:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-12-01; Univ Sao Paulo, Fac Med, Hosp Clin, Sao Paulo, Brazil; Univ Sao Paulo, Fac Med, Sao Paulo, Brazil; Univ Tiradentes, Aracaju, Brazil; Hosp Univ Getulio Vargas, Manaus, Amazonas, Brazil; Hosp Geral Fortaleza, Fortaleza, Ceara, Brazil; Thiago Fukuda, Salvador, BA, Brazil; Hosp Ophir Loyola, Belem, Para, Br...