42 documents found, page 1 of 5
Bilateral Optic Neuropathy as First Manifestation of Tuberculosis
Rufo Costa, Luís; Silva, Rui Pedro; Gomes, Sara; Amorim, Isabel; Santos, Ana Filipa; Cação, Gonçalo; Almeida, Cristina; Machado, CéliaIntraocular tuberculosis is a rare manifestation of Mycobacterium tuberculosis infection. We present a case of an immunocompetent male who presented with subacute binocular vision loss. On examination, he had a visual acuity of 6/10 bilaterally and optic disk edema. Initial workup was negative for structural, autoimmune, infectious or toxic etiologies. He was first treated with methylprednisolone, plasma exchan...
Emergent Carotid Stenting During Endovascular Therapy for Isolated Cervical Int...
Riegler, Christoph; Marto, João Pedro; Gebert, Pimrapat; Reiff, Tilman; Sykora, Marek; Wiącek, Marcin; Pakizer, David; Araújo, AndréBackground and Purpose In patients with ischemic stroke and isolated cervical internal carotid artery occlusion (c-ICA-O), endovascular therapy (EVT) can improve cerebral perfusion. To maintain vessel patency, EVT is frequently combined with carotid artery stenting (CAS). We assessed the efficacy and safety of emergent CAS during EVT for isolated c-ICA-O. Methods This retrospective multinational cohort study (4...
Long-term cardiovascular events in individuals hospitalised with COVID-19
LOCUS group; Soares, Patrícia; Ruivinho, Carolina; Silva, Joana; Lobão, Maria João; Santos, Lelita; Paixão, Joana; Ramalho, Ana Rita; Henriques, AdrianaBackground: Post-COVID condition encompasses a spectrum of persistent or emerging symptoms affecting multiple organ systems, including a heightened risk of cardiovascular complications. Despite growing recognition of this phenomenon, there remains a lack of comprehensive data regarding the incidence and risk factors associated with cardiovascular events during the post-acute phase in patients previously hospita...
Enhancing Autonomy in Preschoolers: The Role of Motor Games in Development
Gomes, Sara; Antunes, Raul; Sales, Inês; Marques, Regina; Oliveira, AnaThis paper is based on a project which aims to understand the contribution of motricity—in particular, motor games—to the development of autonomy in preschool children, with or without special education needs. A group of 18 children, with an average age of 4.5 years, from a public school took part in the study. An intervention program based on motor games was implemented and tested to promote the children’s aut...
Epidemiology and Burden of Ventilator-Associated Pneumonia among adult intensiv...
Mergulhão, Paulo; Pereira, João Gonçalves; Fernandes, Antero Vale; Krystopchuk, Andriy; Ribeiro, João Miguel; Miranda, Daniel; Castro, HeloísaVentilator-associated pneumonia (VAP) is a prevailing nosocomial infection in critically ill patients requiring invasive mechanical ventilation (iMV). The impact of VAP is profound, adversely affecting patient outcomes and placing a significant burden on healthcare resources. This study assessed for the first time the contemporary VAP epidemiology in Portugal and its burden on the healthcare system and clinical...
The functionality of the cancer patient hospitalized in palliative care
Gomes, Sara; Marques, Ângela; Rosete, Marisa; Batista, Paula; Gandum, Filipe; Santos, Maria ConceiçãoBackground: Patients referred for palliative care (PC) need the application of assessment instruments, such as the level of functionality. Objective: Identify the inpatient's sociodemographic and clinical characteristics and characterize their functional capacity. Methodology: A descriptive, longitudinal study of adult cancer patients in a CP unit (n=53) from March to June of 2022. The instruments FIM®, ECOG® a...
Modulation of the tumor microenvironment by microbiota-derived short-chain fatt...
Gomes, Sara; Rodrigues, Ana Catarina; Pazienza, Valerio; Preto, AnaFinding new therapeutic approaches towards colorectal cancer (CRC) is of increased relevance, as CRC is one of the most common cancers worldwide. CRC standard therapy includes surgery, chemotherapy, and radiotherapy, which may be used alone or in combination. The reported side effects and acquired resistance associated with these strategies lead to an increasing need to search for new therapies with better effi...
Response of avian and mammal seed dispersal networks to human-induced forest ed...
Chaves, Patrícia P.; Timóteo, Sérgio; Gomes, Sara; Rainho, AnaSpecies-rich ecosystems as tropical forests are extremely vulnerable to anthropogenic destruction. Most tropical plant species rely on animals to disperse their seeds. However, patterns of mutualistic interactions have rarely been explored, and seed dispersal networks are still poorly studied in Africa. Here, we examine how forest edges’ (FE) seed dispersal networks differ from the mature forest (MF) at a West ...
Colon microbiota modulation by dairy-derived diet: new strategy for prevention ...
Gomes, Sara; Teixeira-Guedes, Catarina; Silva, Elisabete; Baltazar, Fátima; Preto, AnaAn unbalanced diet is one of the well-known risk factors for the development of colorectal cancer (CRC). This type of cancer is currently the main cause of cancer-related deaths worldwide, urging the need for new and more effective preventive and therapeutic approaches. It is already known that CRC patients have alterations in the microbial community and metabolism. In this regard, a concept that has been recen...
Microbiota-derived short-chain fatty acids: new road in colorectal cancer therapy
Gomes, Sara; Baltazar, Fátima; Silva, Elisabete; Preto, AnaThe colon microbiota is an important player in colorectal cancer (CRC) development, which is responsible for most of the cancer-related deaths worldwide. During carcinogenesis, the colon microbiota composition changes from a normobiosis profile to dysbiosis, interfering with the production of short-chain fatty acids (SCFAs). Each SCFA is known to play a role in several biological processes but, despite their re...