Encontrados 19 documentos, a visualizar página 1 de 2
Non-tuberculous cutaneous mycobacterioses,
Nogueira,Lais Bastos; Garcia,Carina Nogueira; Costa,Marcela Santos Corrêa da; Moraes,Monica Brauner de; Kurizky,Patrícia Shu; Gomes,Ciro MartinsAbstract Non-tuberculous mycobacteriosis, previously known as atypical, anonymous, opportunistic, or unclassified mycobacteriosis, refers to pathogenic mycobacterioses other than those caused by Mycobacterium tuberculosis and Mycobacterium leprae. These mycobacteria are known for their environmental distribution, mainly in water and soil. The incidence of non-tuberculous mycobacteriosis has been increasing in a...
Dramatic secukinumab-mediated improvements in refractory leprosy-related neurit...
Kurizky,Patrícia Shu; Motta,Jorgeth de Oliveira Carneiro da; Bezerra,Natanael Victor Furtunato; Sousa,Marcia Carolline dos Santos; Corazza,DaniloAbstract A 39-year-old woman was diagnosed with relapsed multibacillary leprosy and refractory neuritis. Here, we describe an evident loss of therapeutic effectiveness after the third pulse of corticosteroids, which may be attributed to tachyphylaxis and the posterior modulation of interferon- γ (IFN-γ), tumor necrosis factor- α (TNF-α,) interleukin-17A (IL-17A), and IL-12/23p40 after the induction phase of sec...
The accuracy of the Montenegro skin test for leishmaniasis in PCR-negative pati...
Pinheiro,Ana Bárbara Sapienza; Kurizky,Patricia Shu; Ferreira,Marina de Freitas; Mota,Marco Antonio de Souza; Ribeiro,Jaqueline SantosAbstract INTRODUCTION: As highly specific molecular biology-based techniques may not be sensitive enough for the diagnosis of American tegumentary leishmaniasis (ATL), clinicians frequently rely on immunological tests before treatment initiation. Hence, the correct combination of diagnostic tests is imperative for ATL diagnosis. We aimed to evaluate the accuracy of the Montenegro (Leishmanin) skin test (MST) in...
The interference of polypharmacy and the importance of clinical pharmacy advice...
Cerqueira,Selma Regina Penha Silva; Santos,Lais Sevilha dos; Morelo,Elaine Faria; Santos Júnior,Agenor de Castro Moreira dosAbstract INTRODUCTION: Although supervised doses are essential for reducing leprosy treatment failure, the impact of specific drug interactions has rarely been assessed. This study aimed to estimate the risk of leprosy treatment suspension in patients receiving polypharmacy. METHODS We performed this case-control study in which the primary outcome was defined as the need to discontinue multibacillary leprosy tr...
The challenge of concomitant infections in the coronavirus disease 2019 pandemi...
Kurizky,Patricia Shu; Cerqueira,Selma Regina Penha Silva; Cunha,Débora Vilela; Albuquerque,Cleandro Pires de; Aires,Rodrigo BarbosaAbstract Coronavirus disease 2019 (COVID-19) was first officially described in Brazil on February 26th, 2020. The accumulation of reports of concomitant infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and pathogens that cause diseases endemic to tropical countries, such as dengue and chikungunya fever, has started to draw attention. Chagas disease and leprosy remain public health pr...
A randomized, open-label clinical trial comparing the long-term effects of milt...
Sampaio,Raimunda Nonata Ribeiro; Silva,Juliana Saboia Fontenele e; Paula,Carmen Dea Ribeiro de; Porto,Cláudia; Motta,Jorgeth de Oliveira Carneiro daAbstract INTRODUCTION: The treatment of mucosal leishmaniasis (ML) is difficult due to the toxicity and route of administration of standard drugs. Miltefosine is an oral agent used for leishmaniasis treatment; however, no data exist regarding its use for ML in Brazil. In this study, we aimed to evaluate the efficacy of miltefosine for ML treatment compared to that of pentavalent antimonial in a pilot study. MET...
Aplicações do Deep Learning para diagnóstico de doenças e identificação de inse...
Souza,Ewerton Pacheco de; Gomes,Ciro Martins; Barroso,Daniel Holanda; Miranda,Vinícius Lima de; Gurgel-Gonçalves,RodrigoRESUMO Deep Learning é uma técnica de aprendizado de máquina na qual o programa computacional aprende padrões diretamente a partir de imagens classificadas previamente. O presente ensaio objetivou apresentar essa técnica e algumas de suas aplicações para diagnóstico de doenças e identificação de insetos vetores para incentivar profissionais da saúde que não tenham conhecimento aprofundado em informática e que d...
Evaluation of the occurrence of sexual dysfunction and general quality of life ...
Kurizky,Patricia Shu; Martins,Gladys Aires; Carneiro,Jamille Nascimento; Gomes,Ciro Martins; Mota,Licia Maria Henrique daAbstract: Background: Psoriasis has a significant impact on quality of life (QoL). Sexual life can also be affected, with sexual dysfunction being reported by 25-70% of patients. Objectives: To determine the occurrence of sexual dysfunction and evaluate QoL in women with psoriasis. Methods: This case-control study included women aged 18-69 years. The validated Brazilian Portuguese versions of the Female Sexual ...
American cutaneous leishmaniasis triggered by electrocoagulation
Martins,Sofia Sales; Santos,Adriana de Oliveira; Lima,Beatriz Dolabela; Gomes,Ciro Martins; Sampaio,Raimunda Nonata RibeiroAbstract Cutaneous leishmaniasis is usually transmitted by infected phlebotomine sand fly bites that initiate local cutaneous lesions. Few reports in the literature describe other modes of transmission. We report a case of a previously healthy 59-year-old woman who underwent electrocoagulation to remove seborrheic keratosis confirmed by dermatoscopy. Three months later, a skin fragment tested positive for Leish...
Paracoccidioidomycosis and cryptococcosis with localized skin manifestations: r...
Oliveira,Ederson Valei Lopes de; Almeida,Margarete Teresa Gottardo de; Turatti,Aline; Gomes,Ciro Martins; Roselino,Ana MariaAbstract Distinct cases of Paracoccidioidomycosis and Cryptococcosis with atypical and localized skin manifestation on the upper limbs of two elderly patients are reported. In the 2nd one, he presented asymptomatic pulmonary cancer; the blood tests for fungal infection were negative, and the etiologic agents were seen in skin biopsy samples. This report emphasizes the importance of the differential diagnosis of...