Funding Information: This work was supported by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia (FCT, Portugal) through funds to GHTM\u2014UID/04413/2020, LA-REAL\u2014LA/P/0117/2020, to the Project DREBI, Ref. 2022.07931.PTDC (DOI: 10.54499/2022.07931.PTDC), to the grants of M.A. (UI/BD/154472/2022) and J.N. (2022.07931.PTDC), and to the contracts of J.M. (DOI: 10.54499/CEECIND/00450/2017/CP1415/CT0001),...
Funding Information: This study was supported by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia (FCT, Portugal) through funds to GHTM\u2014UID/04413/2020, LA-REAL\u2014LA/P/0117/2020 and to the Project DREBI, Ref. 2022.07931.PTDC ( https://doi.org/10.54499/2022.07931.PTDC ). CISM receives core funding from \u201CAgencia Espa\u00F1ola de Cooperacion Internacional para el Desarollo (AECID)\u201D. MG was su...
Fundação para a Ciência e a Tecnologia through funds to DREBI Project Ref. 2022.07931. PTDC (doi: 10.54499/2022.07931.PTDC); GHTM (UID/04413/2020); LA-REAL (LA/P/0117/2020); UI/BD/154472/2022 (MA); 2022.07931.PTDC (JN) and CEECINST/00042/2021/CP1773/CT0009 (SSC); Galleria mellonella represents a sustainable invertebrate infection model that is gaining interest for pathogenicity and infection, host-pathogen inte...
Financiamento: Fundação para a Ciência e a Tecnologia (FCT), Portugal, através de fundos para o Projeto DREBI Ref. 2022.07931.PTDC; GHTM (UID/04413/2020); LA-REAL (LA/P/0117/2020); Bolsa de doutoramento UI/BD/154472/2022 (MA); bolsa de BI 2022.07931.PTDC (JN) e CEECINST/00042/2021/CP1773/CT0009 (SSC); Galleria mellonella é um modelo larval de infeção que tem ganho destaque na comunidade científica para a avalia...
Funding Information: This study was supported by Project BIOSAFE funded by FEDER through the Programa Operacional Factores de Competitividade–COMPETE, by the Fundação para a Ciência e a Tecnologia (FCT, Portugal) - Grant LISBOA-01-0145-FEDER-030713, PTDC/CAL-EST/30713/2017 and by FCT through grants UI/BD/151061/2021 (CM) and 2021.05063.BD (CF) and funds to GHTM (UID/04413/2020) and the CIISA Project (UID/CVT/00...
Background Staphylococcus aureus (SA) and Staphylococcus epidermidis (SE) are frequent pathogens causing nosocomial infections. Efflux-mediated resistance and biofilm formation may contribute to the emergence of resistance in these species and resilience of such infections to chemotherapeutics. In this work, we applied an in silico drug repurposing strategy to identify drugs that can target efflux and/or biofil...