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Recommendations by the Scientific Department of Neuroimmunology of the Brazilia...
Becker,Jefferson; Ferreira,Lis Campos; Damasceno,Alfredo; Bichuetti,Denis Bernardi; Christo,Paulo Pereira; Callegaro,DagobertoABSTRACT The Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) provide recommendations in this document for vaccination of the population with demyelinating diseases of the central nervous system (CNS) against infections in general and against the severe acut...
Migraine in 746 patients with multiple sclerosis
Fragoso,Yara Dadalti; Adoni,Tarso; Alves-Leon,Soniza V.; Apostolos-Pereira,Samira L.; Carneiro,Marcos A. Diniz; Chikota,Edila M.ABSTRACT Migraine adds to the burden of patients suffering from multiple sclerosis (MS). The ID-migraine is a useful tool for screening migraine, and the Migraine Disability Assessment questionnaire can evaluate disease burden. The aim of the present study was to assess the presence and burden of migraine in patients with MS. Methods: Patients diagnosed with MS attending specialized MS units were invited to ans...
Serological profile of John Cunningham virus (JCV) in patients with multiple sc...
Branco,Luciana Prats; Adoni,Tarso; Apostolos-Pereira,Samira Luisa; Brooks,Joseph Bruno Bidin; Correa,Eber Castro; Damasceno,Carlos AugustoABSTRACT Treatment options for multiple sclerosis (MS) have changed over the last few years, bringing about a new category of drugs with more efficient profiles. However, these drugs have come with a whole new profile of potential adverse events that neurologists have to learn well and quickly. One of the most feared complications of these MS treatments is progressive multifocal leukoencephalopathy caused by th...
High levels of alexithymia in patients with multiple sclerosis
Eboni,Audred Cristina Biondo; Cardoso,Mariana; Dias,Felipe Moreira; Gama,Paulo Diniz da; Gomes,Sidney; Goncalves,Marcus Vinicius MagnoAbstract Alexithymia is a personality trait characterized by difficulties identifying and describing feelings. Some researchers describe high levels of alexithymia among patients with multiple sclerosis (MS) but literature data on this subject are scarce. Objective: The objective of the present study was to characterize findings of alexithymia in patients with MS. Methods: This cross-sectional case-control stud...
Superficial siderosis of the central nervous system is a rare and possibly unde...
Fragoso,Yara Dadalti; Adoni,Tarso; Brooks,Joseph Bruno Bidin; Gomes,Sidney; Goncalves,Marcus Vinicius Magno; Jovem,Cassio LemosABSTRACT Superficial siderosis (SS) of the central nervous system (CNS) is a rare and possibly underdiagnosed disorder resulting from chronic or intermittent bleeding into the subarachnoid space, leading to deposition of blood products in the subpial layers of the meninges. Magnetic resonance imaging (MRI) shows a characteristic curvilinear pattern of hypointensity on its blood-sensitive sequences. Methods Seri...
Cerebrum-cervical arterial dissection in adults during sports and recreation
Fragoso,Yara Dadalti; Adoni,Tarso; Amaral,Lazaro Luiz Faria do; Braga,Flavio Tulio; Brooks,Joseph Bruno Bidin; Campos,Christiane SiqueiraDissection of cervical arteries constitutes a medical emergency. Although relatively rarely, activities classified as sports and recreation may be a cause of arterial dissection independently of neck or head trauma. The purpose of the present paper was to present a series of cases of cerebrum-cervical arterial dissection in individuals during or soon after the practice of these sports activities. Methods Retros...
Patients with multiple sclerosis do not necessarily consume more alcohol or tob...
Fragoso,Yara Dadalti; Gomes,Sidney; Goncalves,Marcus Vinicius M.; Machado,Suzana C. Nunes; Morales,Rogerio de Rizo; Oliveira,Francisco Tomas M. dePurpose Recent papers suggest that patients with multiple sclerosis (MS) are prone to alcohol misuse. This may be due to the combination of a lifelong and disabling disease with a psychiatric profile typical of MS. The objective of the present study was to assess these findings in a culturally different population of patients with MS.Method The present case-control transversal study assessed 168 patients with M...
The real-life experience with cardiovascular complications in the first dose of...
Fragoso,Yara Dadalti; Arruda,Christian Cardoso; Arruda,Walter Oleschko; Brooks,Joseph Bruno Bidin; Damasceno,AlfredoFingolimod is a new and efficient treatment for multiple sclerosis (MS). The drug administration requires special attention to the first dose, since cardiovascular adverse events can be observed during the initial six hours of fingolimod ingestion. The present study consisted of a review of cardiovascular data on 180 patients with MS receiving the first dose of fingolimod. The rate of bradycardia in these patie...
Natalizumab adverse events are rare in patients with multiple sclerosis
Fragoso,Yára Dadalti; Alves-Leon,Soniza Vieira; Arruda,Walter Oleschko; Carvalho,Margarete de Jesus; Comini-Frota,Elizabeth Regina; Corrêa,Éber CastroObjective To assess the prevalence and the profile of adverse events (AE) of natalizumab in patients with multiple sclerosis (MS). Methods Data collection from neurologists attending to patients with MS at specialized units in Brazil. Results Data from 103 patients attending the infusion centers of 16 MS units in 9 Brazilian states were included in the study. The total number of infusions was 1,042. Seventy-nin...
Multiple sclerosis in South America: month of birth in different latitudes does...
Fragoso,Yara Dadalti; Adoni,Tarso; Almeida,Sandra Maria Garcia de; Alves-Leon,Soniza Vieira; Arruda,Walter Oleschko; Barbagelata-Aguero,FiorellaObjective To assess whether the month of birth in different latitudes of South America might influence the presence or severity of multiple sclerosis (MS) later in life. Methods Neurologists in four South American countries working at MS units collected data on their patients' month of birth, gender, age, and disease progression. Results Analysis of data from 1207 MS patients and 1207 control subjects did not s...