2 documents found, page 1 of 1
Maternal γδ T cells shape offspring pulmonary type 2 immunity in a microbiota-d...
Papotto, Pedro H.; Yilmaz, Bahtiyar; Pimenta, Gonçalo; Mensurado, Sofia; Cunha, Carolina; Fiala, Gina; Gomes Da Costa, Daniel; Gonçalves-Sousa, NatachaImmune development is profoundly influenced by vertically transferred cues. However, little is known about how maternal innate-like lymphocytes regulate offspring immunity. Here, we show that mice born from γδ T cell-deficient (TCRδ-/-) dams display an increase in first-breath-induced inflammation, with a pulmonary milieu selectively enriched in type 2 cytokines and type 2-polarized immune cells, when compared ...
Interplay between liver and blood stages of Plasmodium infection dictates malar...
Chora, Ângelo Ferreira; Marques, Sofia; Lisboa Gonçalves, Joana; Lima, Priscila; Gomes Da Costa, Daniel; Fernandez-Ruiz, Daniel; Marreiros, Maria InêsPlasmodium replicates within the liver prior to reaching the bloodstream and infecting red blood cells. Because clinical manifestations of malaria only arise during the blood stage of infection, a perception exists that liver infection does not impact disease pathology. By developing a murine model where the liver and blood stages of infection are uncoupled, we showed that the integration of signals from both s...