5 documents found, page 1 of 1
Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease...
Chegão, Ana; Guarda, Mariana; Alexandre, Bruno M.; Shvachiy, Liana; Temido Ferreira, Mariana; Marques-Morgado, Inês; Fernandes Gomes, BárbaraAlpha-synuclein (aSyn) is a central player in the pathogenesis of synucleinopathies due to its accumulation in typical protein aggregates in the brain. However, it is still unclear how it contributes to neurodegeneration. Type-2 diabetes mellitus is a risk factor for Parkinson's disease (PD). Interestingly, a common molecular alteration among these disorders is the age-associated increase in protein glycation. ...
Lumbar myofascial physical properties in healthy adults
M. Pimentel-Santos, F.; Rodrigues Manica, Santiago; Alfonse, T. Masi; Gomes, JL; Baptista, Mariana; Ramiro, Sofia; Sepriano, Alexandre; Nair, K.Funding Information: Portuguese Society of Rheumatology grant. Publisher Copyright: © 2021, The Official Journal Of The Portuguese Society Of Rheumatology. All rights reserved.; Objective: The human resting myofascial tone maintains the body tone in a neutral posture, the assessment of this and other muscle physical properties (MPP) is relevant, since, it is altered in many pathological states. Patients and met...
Rescue of F508del-CFTR by RXR motif inactivation triggers proteome modulation a...
Gomes-Alves, Patrícia; Couto, Francisco; Pesquita, Cátia; Coelho, Ana V.; Penque, DeborahF508del-CFTR, the most common mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, disrupts intracellular trafficking leading to cystic fibrosis (CF). The trafficking defect of F508del-CFTR can be rescued by simultaneous inactivation of its four RXR motifs (4RK). Proteins involved in the F508del-CFTR trafficking defect and/or rescue are therefore potential CF therapeutic targets. ...
Proteomics uncovering possible key players in F508del-CFTR processing and traff...
Gomes-Alves, Patrícia; Penque, DeborahThe achievement and maintenance of a protein native conformation is a very complex cellular process involving a multitude of key factors whose contribution to a successful folding remains to be elucidated. On top of this, it is known that correct folding is crucial for proteins to play their normal role and, consequently, for the maintenance of cellular homeostasis or proteostasis. If the folding process is aff...
SELDI-TOF biomarker signatures for cystic fibrosis, asthma and chronic obstruct...
Gomes-Alves, Patrícia; Imrie, Margaret; Gray, Robert D.; Nogueira, Paulo; Ciordia, Sergio; Pacheco, Paula; Azevedo, Pilar; Lopes, CarlosOBJECTIVES: The aim of this work was to establish protein profiles in serum and nasal epithelial cells of cystic fibrosis individuals in comparison with controls, asthma and chronic obstructive pulmonary disease patients for specific biomarker signatures identification. DESIGN AND METHODS: Protein extracts were analyzed by Surface Enhanced Laser Desorption/Ionization Time-Of-Flight Mass-Spectrometry (SELDI-TOF-...