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Screening Wild Birds for Tick-Borne Zoonotic Pathogens in Portugal
Loureiro, F; Mesquita, JR; Cardoso, L; Santos-Silva, S; Moreira, G; Bento, JT; Soeiro, V; Gonçalves, A; Silva, F; Barradas, PF; Matos, AC; Matos, MWild birds may be involved in the transmission of agents of infectious diseases, including zoonoses, a circumstance which raises a number of public and animal health issues. Migratory bird species play a significant role in the introduction of tick-borne pathogens to new geographic areas, contributing to the dissemination of various etiological agents. This preliminary study aimed to assess the occurrence of fo...
Cyto-Histological Profile of MicroRNAs as Diagnostic Biomarkers in Differentiat...
Matos, ML; Pinto, M; Alves, M; Canberk, S; Gonçalves, A; Bugalho, MJ; Papoila, AL; Soares, PIntroduction: The repertoire of microRNAs (miRNAs) in thyroid carcinomas starts to be elucidated. Among differentiated thyroid carcinomas (DTCs), papillary thyroid carcinoma (PTC) is the most frequent. The assessment of miRNAs expression may contribute to refine the pre-surgical diagnosis in order to obtain a personalized and more effective treatment for patients. Aims: This study aims to evaluate (1) the miRNA...
The Cardiometabolic Impact of Rebaudioside A Exposure during the Reproductive S...
Bracchi, I; Morais, J; Coelho, JA; Ferreira, AF; Alves, I; Mendes, C; Correia, B; Gonçalves, A; Guimarães, JT; Pires, IF; Keating, E; Negrão, RThe consumption of non-sugar sweeteners (NSS) has increased during pregnancy. The European Food Safety Agency suggested that steviol glycosides, such as Rebaudioside A (RebA), the major sweetener component of stevia, are safe for humans up to a dose of 4 mg/kg body weight/day. However, the World Health Organization recommended in 2023 the restraint of using NSS, including stevia, at any life stage, highlighting...
In vitro bioaccessibility and intestinal transport of retinoic acid in ethyl ce...
Gonçalves, A; Viegas, Olga; Faria, A; Ferreira, MPLVO; Rocha, F; Estevinho, NThe development of carrier-based delivery systems for oral administration of retinoic acid (RA), that provides its release and absorption at intestinal level, is of major relevance in the treatment of acute promyelocytic leukemia. The aim of this work was to evaluate RA bioaccessibility and intestinal transport on ethyl cellulose (EC)- and EC + polyethylene glycol (ECP)-based microparticles and to understand th...
Influence of HER2 expression on prognosis in metastatic triple-negative breast ...
Gampenrieder, SP; Dezentjé, V; Lambertini, M; de Nonneville, A; Marhold, M; Le Du, F; Cortés Salgado, A; Alpuim Costa, D; Vaz Batista, M; Chic Ruché, NBackground: Triple-negative breast cancer (TNBC) is associated with poor prognosis, and new treatment options are urgently needed. About 34%-39% of primary TNBCs show a low expression of human epidermal growth factor receptor 2 (HER2-low), which is a target for new anti-HER2 drugs. However, little is known about the frequency and the prognostic value of HER2-low in metastatic TNBC. Patients and methods: We retr...
Levosimendan in Outpatients with Advanced Heart Failure: Single-Center Experien...
Ferreira Reis, J; Gonçalves, A; Ilhão Moreira, R; Pereira-da-Silva, T; Timóteo, AT; Pombo, D; Carvalho, T; Correia, C; Santos, C; Cruz Ferreira, RIntroduction: Patients with advanced heart failure (HF) have high morbidity and mortality, with only a small proportion being eligible for advanced therapies. Intermittent outpatient levosimendan infusion has been shown to provide symptomatic relief and reduce the rate of HF events. Our aim was to assess the safety and efficacy of outpatient levosimendan administration in an advanced HF population. Methods: Thi...
Myocardial Work Brings New Insights into Left Ventricular Remodelling in Cardio...
Vaz Ferreira, V; Mano, T; Cardoso, I; Coutinho Cruz, M; Branco, LM; Almeida-Morais, L; Timóteo, AT; Galrinho, A; Castelo, A; Garcia Brás, P; Simão, DSerial transthoracic echocardiographic (TTE) assessment of 2D left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS) are the gold standard screening methods for cancer therapeutics-related cardiac dysfunction (CTRCD). Non-invasive left ventricular (LV) pressure-strain loop (PSL) provides a novel method of quantifying myocardial work (MW) with potential advantages to evaluate the impact o...
Blunted Coronary Flow Velocity Reserve is Associated With Impairment in Systoli...
Aguiar Rosa, S; Rocha Lopes, L; Branco, L; Galrinho, A; Fiarresga, A; Thomas, B; Brás, P; Gonçalves, A; Cardoso, I; Papoila, A; Alves, M; Rio, PBackground Coronary microvascular dysfunction constitutes an important pathophysiological feature in hypertrophic cardiomyopathy (HCM). We aimed to assess the association between impaired coronary flow velocity reserve (CFVR) and ventricular systolic function and functional capacity. Methods Eighty-three patients with HCM were enrolled in this prospective cohort study. Patients underwent echocardiogram to evalu...
Prevalence and Prognostic Impact of Apical Sparing Contractility Pattern in Pat...
Ferreira, V; Aguiar Rosa, S; Pereira-da-Silva, T; Rodrigues, I; Gonçalves, A; Mendonça, T; Castelo, A; Branco, LM; Galrinho, A; Fiarresga, A; Ramos, RIntroduction: Prolonged afterload increase in aortic stenosis (AS) may alter left ventricular (LV) contractility, irrespective of LV ejection fraction (LVEF). The prevalence and morbimortality associated with the apical sparing strain pattern (ASP), a typical finding of cardiac amyloidosis (CA), are not fully understood in patients with AS. We assessed the prevalence of the ASP in patients with severe AS and it...
P–042 Impact of semen parameters, sperm DNA fragmentation and sperm aneuploidy ...
Maia, M; Almeida, C; Cunha, M; Gonçalves, A; Soares, SS; Severo, M; Marques, CJ; Barros, AMD; Doria, S; Sousa, MStudy question. Should sperm aneuploidies and sperm DNA fragmentation (sDNAfrag) be included as valid tests in the routine investigation of male infertility? Summary answer. Sperm DNA fragmentation was associated with male age, oligozoospermia (OZ), oligoteratozoospermia (OT), astenoteratozoospermia (AT) and oligoastenoteratozoospermia (OAT). Sperm aneuploidies were associated with OT and OAT. What is known alr...