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Clinical and Epidemiological Features of Hospitalized and Ambulatory Patients w...
Caria, J; Pinto, R; Leal, E; Almeida, V; Cristóvão, G; Gonçalves, AC; Torres, M; Santos, MB; Pinheiro, H; Póvoas, D; Seixas, D; Lino, S; Cardoso, OMonkeypox, a neglected and re-emergent zoonotic disease caused by monkeypox virus (MPXV) infection, has been endemic in Central and Western Africa for decades. More recently, an outbreak has spread to a global level, occurring in sites with no previous reported cases and being clustered among men who have sex with men, suggesting new modes of transmission. There is an urgent need for research for a better under...
Kinetics of radium-223 and its effects on survival, proliferation and DNA damag...
Marques, IA; Abrantes, AM; Pires, AS; Neves, AR; Caramelo, FJ; Rodrigues, T; Matafome, P; Tavares-da-Silva, E; Gonçalves, AC; Pereira, CC; Teixeira, JPBackground Metastatic castration-resistant prostate cancer (mCRPC) is associated with a very unfavorable prognosis. At this advanced stage of the disease, there are several therapeutic strategies approved in recent times, being one of them Radium-223 dichloride (Radium-223). However, its mechanisms of action and the process that conducts to cell death are not fully understood. Given this, our main goal is to ch...
ECM-enriched alginate hydrogels for bioartificial pancreas: an ideal niche to i...
Crisóstomo, J; Pereira, AM; Bidarra, SJ; Gonçalves, AC; Granja, PL; Coelho, JFJ; Barrias, CC; Seiça, RIntroduction: The success of a bioartificial pancreas crucially depends on ameliorating encapsulated beta cells survival and function. By mimicking the cellular in vivo niche, the aim of this study was to develop a novel model for beta cells encapsulation capable of establishing an appropriate microenvironment that supports interactions between cells and extracellular matrix (ECM) components. Methods: ECM compo...
Aberrant p15, p16, p53, and DAPK Gene Methylation in Myelomagenesis: Clinical a...
Geraldes, C; Gonçalves, AC; Cortesão, E; Pereira, MI; Roque, A; Paiva, A; Ribeiro, L; Nascimento-Costa, JM; Sarmento-Ribeiro, ABBACKGROUND: Aberrant DNA methylation is considered a crucial mechanism in the pathogenesis of monoclonal gammopathies. We aimed to investigate the contribution of hypermethylation of 4 tumor suppressor genes to the multistep process of myelomagenesis. METHODS: The methylation status of p15, p16, p53, and DAPK genes was evaluated in bone marrow samples from 94 patients at diagnosis: monoclonal gammopathy of unce...
Impact of splenic artery ligation after major hepatectomy on liver function, re...
Carrapita, J; Abrantes, AM; Campelos, S; Gonçalves, AC; Cardoso, D; Sarmento-Ribeiro, AB; Rocha, C; Santos, JN; Botelho, MF; Tralhão, JG; Farges, OIt was reported that prevention of acute portal overpressure in small-for-size livers by inflow modulation results in a better postoperative outcome. The aim is to investigate the impact of portal blood flow reduction by splenic artery ligation after major hepatectomy in a murine model. Forty-eight rats were subjected to an 85% hepatectomy or 85% hepatectomy and splenic artery ligation. Both groups were evaluat...
Traqueobroncopatia Osteocondroplástica: um caso raro de lesão laringo-traqueal
Miranda, D; Pereira, S; Breda, M; Vilarinho, S; Gonçalves, AC; Lacerda, C; Rolo, R; Dias, L
Influence of P53 on the radiotherapy response of hepatocellular carcinoma
Gomes, AR; Abrantes, AM; Brito, AF; Laranjo, M; Casalta-Lopes, JE; Gonçalves, AC; Sarmento-Ribeiro, AB; Botelho, MF; Tralhão, JGHepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and it has a poor prognosis and few therapeutic options. Radiotherapy is one of the most effective forms of cancer treatment, and P53 protein is one of the key molecules determining how a cell responds to radiotherapy. The aim of this study was to determine the therapeutic efficacy of iodine-131 in three human HCC cell lines.
Spectrum and Frequency of GJB2 Mutations in a Cohort of 264 Portuguese Nonsyndr...
Matos, T; Simões-Teixeira, H; Caria, H; Gonçalves, AC; Chora, J; Correia, MC; Moura, C; Rosa, H; Monteiro, L; O'Neill, A; Dias, O; Andrea, M; Fialho, GOBJECTIVE: To assess the spectrum and prevalence of mutations in the GJB2 gene in Portuguese nonsyndromic sensorineural hearing loss (NSSHL) patients. DESIGN: Sequencing of the coding region, basal promoter, exon 1, and donor splice site of the GJB2 gene; screening for the presence of the two common GJB6 deletions. STUDY SAMPLE: A cohort of 264 Portuguese NSSHL patients. RESULTS: At least one out of 21 differen...
Study of hepatocellular function in the murine model following hepatic artery s...
Tralhão, JG; Abrantes, AM; Gonçalves, AC; Hoti, E; Laranjo, M; Martins, R; Oliveiros, B; Cardoso, D; Sarmento-Ribeiro, AB; Botelho, MFPURPOSE: To investigate the impact of selective hepatic artery clamping (SHAC) in hepatocellular function. METHODS: Three groups of Wistar male rats were subjected to SHAC ischemia period of 60min: Group A continuous SHAC were subjected to SHAC ischemia period of 60min, Group B intermittent SHAC of 30min with 5min of reperfusion and Group C intermittent SHAC of 15min with 5min of reperfusion. Animals without SH...
Evaluation of Apoptotic Molecular Markers in Myelodysplastic Syndrome Patients
Cortesão, E; Gonçalves, AC; Sousa, I; Moucho, C; Rito, L; Espadana, AI; Magalhães, E; Pereira, AM; Teixeira, A; Nascimento-Costa, JM; Sarmento, AB