41 documents found, page 1 of 5
Elastin-like recombinamers as a biotechnological platform for the development o...
Gonçalves, Anabela; Pinho, Vanessa; da Costa, André; Ribeiro, Artur; Gomes, Andreia C; Machado, RaulOncostatin M (OSM) and leukemia inhibitory factor (LIF) are pleiotropic cytokines from the interkeukine-6 family, associated with several disorders, and present significant potential in biomedicine. However, their therapeutic use is highly constrained by factors such as short circulating half-life and narrow therapeutic window. The conjugation of cytokines with elastin-like recombinamers (ELR) holds the potenti...
Nanotechnology to the rescue: therapeutic strategies based on brown algae for n...
Gonçalves, Anabela; Fernandes, Mário; Lima, Margarida; Gomes, João Pedro; Silva, Filipa; Castro, Sara; Sampaio, Filipa; Gomes, Andreia CIn the last decades, marine macroalgae have drawn attention mainly because of their bioactive constituents. Most brown algae are distributed over coastal areas of the Atlantic Ocean, Mediterranean Sea, Aegean Sea and Black Sea, and their composition varies with endogenous and exogenous factors. Phlorotannins, fatty acids, sterols and carbohydrates are some of the compounds responsible for biological activities ...
Núcleos funcionais e variação linguística: o caso da Reestruturação
Gonçalves, AnabelaA ideia de que a variação linguística se deve a propriedades dos núcleos funcionais remonta à década de 1980 (e.g. Borer 1984), tendo assumido particular importância em diversos trabalhos realizados no modelo do quadro generativista conhecido como Programa Minimalista. Neste artigo, pretende-se apresentar evidência adicional a favor desta ideia. Para tal, será analisado o contraste entre português europeu (PE) ...
VENOUS GANGRENE: REMINDING A VASCULAR CATASTROPHE
Novais Lima, Pedro; Cruz Silva, Joana; Gonçalves, Anabela; Fonseca, ManuelA 85 year-old, female patient, with an active colon neoplasm, was diagnosed with extensive ilio-femoro-popliteal deep vein thrombosis. She presented with severe oedema of the left lower limb and a cyanotic foot. Pedal pulses were palpable. Despite immediate anticoagulation, the patient expired at 72h.
MYCOTIC EXTRACRANIAL CAROTID ARTERIES ANEURYSMS – SYSTEMATIC REVIEW OF THE LITE...
Lima, Pedro; Moreira, Mário; Correia, Mafalda; Pereira, Bárbara; Silva, Joana; Constâncio, Vânia; Gonçalves, Anabela; Fonseca, ManuelIntroduction: Mycotic extracranial carotid artery aneurysms are extremely unusual, with only around 100 cases published in the literature. They represent a challenge due to delayed presentations, possible catastrophic consequences if left untreated, as well as high morbidity after surgical management. Knowledge about infectious aneurysms on this territory remains limited to case reports. Thus, the authors prete...
Toxicity in vitro and in zebrafish embryonic development of gold nanoparticles ...
Machado, Sofia; González-Ballesteros, Noelia; Gonçalves, Anabela; Magalhães, Luana; Passos, Marisa Sárria Pereira; Rodríguez-Argüelles, Maria CarmenIntroduction: Research on gold nanoparticles (AuNPs) occupies a prominent place in the field of biomedicine nowadays, being their putative toxicity and bioactivity areas of major concern. The green synthesis of metallic nanoparticles using extracts from marine organisms allows the avoidance of hazardous production steps while maintaining features of interest, thus enabling the exploitation of their promising bi...
PROSTHETIC VASCULAR GRAFT INFECTION — STILL AN ENTITY TO FEAR?
Lima, Pedro; Silva, Cândida G.; Antunes, Luís; Moreira, Mário; Correia, Mafalda; Silva, Joana; Gonçalves, Anabela; Gonçalves, ÓscarIntroduction: The evolution on aseptic technique and prophylactic antibiotherapy has been keeping a low incidence of prosthetic vascular graft infections (PVGI). However some patients are still at risk of a disease that compromises the graft function and the viability of the perfused organ, while threatening each individual with septic complications. The management of PVGI depends on the severity of infection, ...
On syntactic interference in translation and authentic writing
Colaço, Madalena; Gonçalves, AnabelaIn translation contexts, translators must activate two distinct grammars, as well as pragmatic conditions that may also be distinct. This particular case of languages in contact may give rise to inadequacies or errors, sometimes explained as the result of transferring properties of the source language to the target language. Focussing on the results presented in Gonçalves & Colaço (2019), who analysed some ...
Nanotechnology solutions for controlled cytokine delivery: an applied perspective
Gonçalves, Anabela; Machado, Raul; Gomes, Andreia C; Costa, AndréAround 200 cytokines with roles in cell signaling have been identified and studied, with the vast majority belonging to the four-α-helix bundle family. These proteins exert their function by binding to specific receptors and are implicated in many diseases. The use of several cytokines as therapeutic targets has been approved by the FDA, however their rapid clearance in vivo still greatly limits their efficacy....
Infeção de próteses vasculares - ainda uma entidade a temer?
Lima, Pedro; Silva, Cândida G.; Antunes, Luís; Moreira, Mário; Correia, Mafalda; Silva, Joana; Gonçalves, Anabela; Gonçalves, ÓscarA evolução na técnica de assepsia e antibioterapia profilática tem mantido a incidência de infeção de próteses vasculares (IPV) baixa. No entanto, uma proporção de doentes ainda se encontra suscetível a uma patologia que coloca em risco a função do enxerto e do órgão-alvo perfundido, enquanto ameaça com complicações sépticas a vida de cada um dos afetados.A abordagem das IPV depende da manifestação da infeção e...