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Effects of pulmonary rehabilitation during acute exacerbations of COPD

Machado, Ana Filipa; Dias, Cíntia; Gonçalves, António Pedro; Burtin, Chris; Marques, Alda

Uncertainty exists about the safety and beneficial effects of delivering pulmonary rehabilitation (PR) during acute exacerbations of COPD (AECOPD). We explored the effects of a home-based PR programme during moderate AECOPD. A randomized controlled trial was conducted (NCT03751670). Patients with AECOPD were randomly assigned to the control (CG, i.e., standard medication) or experimental (EG, i.e., standard med...


Effects of home-based pulmonary rehabilitation on the functional status of pati...

Machado, Ana; Dias, Cíntia; Gonçalves, António Pedro; Burtin, Chris; Marques, Alda

Exacerbations of chronic obstructive pulmonary disease (ECOPD), which are defined as an acute worsening of respiratory symptoms that result in additional therapy, have a negative impact on patients’ functional status and disease progression. Pulmonary rehabilitation (PR) is a well-established intervention for the management of patients with stable disease, however uncertainty exists about the safety and benefic...


Effects at 2-months follow-up of pulmonary rehabilitation in outpatients with a...

Machado, Ana; Dias, Cíntia; Gonçalves, António Pedro; Burtin, Chris; Marques, Alda

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Point-Of-Care-Ultrasound in Internal Medicine: A Paradigm Shift in the Evaluati...

Mariz, José; Silva, Rafael; Romano, Miguel; Gaspar, António; Gonçalves, António Pedro; Silva, João Paulo; Carvalho-Filho, Marco António; Santos, Thiago

The point of care ultrasound (POCUS) presents itself as the fifth pillar of the physical examination, pairing with inspection, percussion, palpation and auscultation. After the initial usage, in the beginning of the 80’s for the evaluation of abdominal trauma, the POCUS became a daily practice in the critical patient evaluation, either in Critical Care Units or in Emergency Departments, assuming, nowadays, an i...


Cut-off scores of the mMRC and CAT to predict short-term exacerbations in peopl...

Machado, Ana; Dias, Cíntia; Gonçalves, António Pedro; Mendes, Maria Aurora; Martins, Vitória; Simão, Paula; Burtin, Chris; Marques, Alda

Introduction: Research on prediction and prevention of acute ex-acerbations in people with chronic obstructive pulmonary disease (AECOPD) has become a priority since these events are frequent and have a negative impact on health status and disease progression. Dyspnoea and poor health status, which can be assessed with the modified Medical Research Council dyspnoea questionnaire (mMRC) and the COPD assessment t...


TERT promoter mutations in pancreatic endocrine tumours are rare and mainly fou...

Vinagre, João; Nabais, Joana; Pinheiro, Jorge; Batista, Rui; Oliveira, Rui Caetano; Gonçalves, António Pedro; Pestana, Ana; Reis, Marta

One of the hallmarks of cancer is its unlimited replicative potential that needs a compensatory mechanism for the consequential telomere erosion. Telomerase promoter (TERTp) mutations were recently reported as a novel mechanism for telomerase re-activation/expression in order to maintain telomere length. Pancreatic endocrine tumors (PETs) were so far recognized to rely mainly on the alternative lengthening of t...


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