17 documents found, page 1 of 2
Application of antisense therapy to control Nakaseomyces glabratus infections
Serra, Patrícia; Gonçalves, Bruna; Henriques, Mariana; Castro, Joana; Araújo, Daniela; Silva, Sónia CarinaCanclicla infections affect billions of people worlclwicle, with high morbidity ancl mortality rates (40-60CX,) [l] ancl require long hospital stays ancl increase healthcare costs, which places a significant socio-economic burclen on the economy [2]. Canclicla glabrata (now reclassified as Nakaseomyces glabratus) poses a significant clinical challenge, clue to its increasing levels of resistance to conventional...
Comparative study of the virulence and pathogenicity profiles of Candida glabra...
Gonçalves, Sílvia; Machado, Rayana; Henriques, Mariana; Silva, Sónia Carina; Gonçalves, BrunaVulvovaginal candidiasis (VVC) is a globally prevalent infection caused by commensal fungi that can become pathogenic under certain conditions. Among these fungi, Candida glabrata is particularly concerning due to its low susceptibility to standard antifungal treatments and the rise of antifungal resistance, leading to an increase in severe cases. Additionally, C. glabrata exhibits aggressive virulence factors,...
Combined application of antisense oligomers to control transcription factors of...
Araújo, Daniela Eira; Gonçalves, Bruna; Vilas-Boas, Diana Patrícia Andrade; Rodrigues, M. Elisa; Henriques, Mariana; Silva, Sónia CarinaAntisense oligomers (ASOs) have been little exploited to control determinants of Candida albicans virulence. Biofilm formation is an important virulence factor of C. albicans, that is regulated by a complex network of transcription factors (such as EFG1, BRG1 and ROB1). Thus, the main goal of this work was to project ASOs, based on the 2'-OMethyl chemical modification, to target BRG1 and ROB1 mRNA and to valida...
Sfl1 is required for Candida albicans biofilm formation under acidic conditions
Gonçalves, Bruna; Barbosa, Ana; Soares, Ana Raquel; Henriques, Mariana; Silva, SóniaCandida albicans is a common Candida species, responsible for infections in various anatomical sites under different environmental conditions, aggravated in the presence of its biofilms. As such, this study aimed to reveal the regulation of C. albicans biofilms under acidic conditions by the transcription factor Sfl1, whose role on biofilm formation is unclear. For that, microbiologic and transcriptomic analyse...
Propriedade intelectual no meio digital: desenvolvimento de um website informativo
Gonçalves, BrunaSubmitted by Diego Brandao (diego.brandao@ifpb.edu.br) on 2022-04-29T19:25:28Z No. of bitstreams: 1 Propriedade Intelectual no Meio Digital - Bruna Goncalves.pdf: 11523443 bytes, checksum: e91098c84b88878d5d63402443c9725c (MD5); Approved for entry into archive by Thiago Oliveira (thiago.oliveira@ifpb.edu.br) on 2022-05-01T12:42:53Z (GMT) No. of bitstreams: 1 Propriedade Intelectual no Meio Digital - Bruna Gonca...
Exploring bioinformatics tools and databases to decipher the proteome of Candid...
Gonçalves, Bruna; Silva, Sónia CarinaCandida glabrata is a clinically relevant human pathogen with ability to form high recalcitrant biofilms, which produce an extracellular matrix suggested to have structural, virulent and protective roles. Thus, elucidation of matrix components, their function and regulation, is crucial to disclose matrix role in C. glabrata pathogenesis. As such, this study aimed to reveal, the matrix proteome of C. glabrata bi...
Revealing Candida glabrata biofilm matrix proteome: global characterization and...
Gonçalves, Bruna; Azevedo, Nuno; Osório, Hugo; Henriques, Mariana; Silva, Sónia CarinaCandida glabrata is a clinically relevant human pathogen with the ability to form high recalcitrant biofilms that contribute to the establishment and persistence of infection. A defining trait of biofilms is the auto-produced matrix, which is suggested to have structural, virulent and protective roles. Thus, elucidation of matrix components, their function and modulation by the host environment is crucial to di...
Environmental pH modulates biofilm formation and matrix composition in Candida ...
Gonçalves, Bruna; Fernandes, L.; Henriques, Mariana; Silva, Sónia CarinaCandida species are fungal opportunistic pathogens capable of colonizing and infecting various human anatomical sites, where they have to adapt to distinct niche-specific pH conditions. The aim of this study was to analyse the features of Candida albicans and Candida glabrata biofilms developed under neutral and vaginal acidic (pH 4) conditions. C. albicans produced thicker and more filamentous biofilms under n...
Effect of progesterone on Candida albicans biofilm formation under acidic condi...
Gonçalves, Bruna; Bernardo, Ruben; Wang, Can; Schroeder, Markus; Pedro, Nuno A.; Butler, Geraldine; Azeredo, Joana; Henriques, MarianaVulvovaginal candidiasis (VVC) caused by Candida albicans is a common disease worldwide. A very important C. albicans virulence factor is its ability to form biofilms on epithelium and/or on intrauterine devices promoting VVC. It has been shown that VVC has a hormonal dependency and that progesterone affects virulence traits of C. albicans cells. To understand how the acidic environment (pH 4) and progesterone ...
Hidrogel formador de filme com atividade antioxidante para uso tópico contra o ...
Gonçalves, BrunaTCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Farmácia.; O mercado de cosméticos, principalmente a área relacionada ao envelhecimento facial, cresce a cada ano, exigindo o desenvolvimento de novos produtos e tecnologias para o combate e prevenção desse. Entre os ativos mais promissores para este fim destacam-se os antioxidantes, cuja função é neutralizar os efeitos nocivo...