17 documents found, page 1 of 2
An injectable, naproxen-conjugated, supramolecular hydrogel with ultra-low crit...
Oliveira, Carlos Bruno Pereira; Veloso, Sérgio Rafael Silva; Castanheira, Elisabete M. S.; Figueiredo, Pedro R.; Carvalho, Alexandra T.P.; Hilliou, L.Short peptides capped on the N-terminus with aromatic groups are often able to form supramolecular hydrogels—self-assembled networks of fibrils able to trap water molecules. Typically, these hydrogelators can form stiff gels at concentrations of 0.1 to 1.0 wt%—i.e. they consist of mainly water. The properties of these soft materials mimic those of the extracellular matrix (ECM) of biological tissue and therefor...
Peptide-based supramolecular hydrogels as drug delivery agents: recent advances
Oliveira, Carlos Bruno Pereira; Gomes, Valéria; Ferreira, Paula M. T.; Martins, José A.; Jervis, Peter JohnSupramolecular peptide hydrogels have many important applications in biomedicine, including drug delivery applications for the sustained release of therapeutic molecules. Targeted and selective drug administration is often preferential to systemic drug delivery, as it can allow reduced doses and can avoid the toxicity and side-effects caused by off-target binding. New discoveries are continually being reported ...
Complexes of Bifunctional DO3A-N-(α-amino)propinate Ligands with Mg(II), Ca(II)...
Garda, Zoltán; Kócs, Tamara; Bányai, István; Martins, José A.; Kálmán, Ferenc Krisztián; Tóth, Imre; Geraldes, Carlos F. G. C.; Tircsó, GyulaThe thermodynamic, kinetic, and structural properties of Ln3+ complexes with the bifunctional DO3A-ACE4- ligand and its amide derivative DO3A-BACE4- (modelling the case where DO3A-ACE4- ligand binds to vector molecules) have been studied in order to confirm the usefulness of the corresponding Gd3+ complexes as relaxation labels of targeted MRI contrast agents. The stability constants of the Mg2+ and Ca2+ comple...
Initial screening of poly(ethylene glycol) amino ligands for affinity purificat...
Silva, Nuno Miguel Sampaio Ribeiro Magalhães; Jorge, Paula Alexandra Silva; Martins, José A.; Teixeira, J. A.; Marcos, João C.Gene therapy and DNA vaccination are among the most expected biotechnological and medical advances for the coming years. However, the lack of cost-effective large-scale production and purification of pharmaceutical-grade plasmid DNA (pDNA) still hampers their wide application. Downstream processing, which is mainly chromatography-based, of pDNA remains the key manufacturing step. Despite its high resolution, th...
Património arbóreo. Cidade de Castelo Branco
Alegria, C.M.M.; Alegria, Catarina; Martins, José A.Património arbóreo. Cidade de Castelo Branco
New biocompatible peptide-based hydrogels as drug nanocarriers
Hortelão, Ana C. L.; Vilaça, Maria Helena Pereira; Hermenegildo, Bruno F.; Pereira, Maria Goreti Carvalho; Xu, Bing; Queiroz, Maria João R. P.In this work, several new hydrogelators were developed, containing a Naproxen or a Naphthalene group, and their critical aggregation concentrations were determined by fluorescence. The influence of pH on the aggregation of these molecules was also investigated.
Ga[NO2A-N-(alfa-amino)propionate] chelates: synthesis and evaluation as potenti...
Ferreira, Miguel F.; Pereira, Goreti; André, João P.; Prata, M. I. M.; Ferreira, Paula M. T.; Martins, José A.; Geraldes, Carlos F. G. C.The availability of commercial 68Ge/68Ga cyclotron-independent 68Ga3+ generators is making Positron Emission Tomography (PET) accessible to most hospitals, which is generating a surge of interest in the design and synthesis of bi-functional chelators for Ga3+. In this work we introduce the NO2A-N-(alfa-amino)propionic acid family of chelators based on the triazacyclononane scaffold. Complexation of the parent N...
Amide conjugates of the DO3A-N-(alpha-amino)propionate ligand: leads for stable...
Ferreira, Miguel Filipe Moreira Marques; Martins, André F.; Martins, Catarina I. O.; Ferreira, Paula M. T.; Tóth, Éva; Rodrigues, Tiago B.A novel synthetic methodology for preparing amide conjugates of the DO3A-N-(alfa-amino)propionate chelator is described, using the synthesis of the DO3A-N-(alfa-benzoylamido)propionate chelator as an illustrative example. The model Gd(DO3A-N-(alfa-benzoylamido)propionate) chelate displays accelerated water exchange, stability in a wide pH range and inertness towards transmetallation by Zn2+. The Gd(DO3A-N-(alaf...
NMR and molecular modelling studies on elastase inhibitor-peptides for wound ma...
Barros, Sandra Cerqueira; Louro, Ricardo O.; Micaelo, N. M.; Martins, José A.; Marcos, João Carlos; Paulo, Artur CavacoProteases play an important and critical role in the physiological process of wound repair. However, excessive and unregulated release of proteolytic enzymes (e.g., elastase) mediates abnormal degradation of healthy tissues, which leads to inflammatory disorders such as chronic wounds. Thus, it is of therapeutic interest to develop novel synthetic inhibitor-peptides of elastase, which can restore the balance be...
Synthesis of 2,6-bis-(oxazolyl)pyridine ligands for luminescent Ln(III) complexes
Pereira, Goreti; Ferreira, Paula M. T.; Castanheira, Elisabete M. S.; Martins, José A.; Ferreira, Miguel Filipe Moreira MarquesNew bis-(oxazolyl)pyridine ligands for Ln(III) ions were prepared using a expeditious methodology from threonine and dipicolinic acid chloride. The synthetic strategy includes a dehydration step to give a bis-dehydroaminobutyric acid derivative followed by bromination and cyclization with DBU. Photophysical studies of Eu(III) and Tb(III) complexes of these ligands showed that the 2,6-bis-(oxazolyl)pyridine moie...