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Revisiting mutational resistance to ampicillin and cefotaxime in Haemophilus in...
Diricks, Margo; Petersen, Sabine; Bartels, Lennart; Lâm, Thiên-Trí; Claus, Heike; Bajanca-Lavado, Maria Paula; Hauswaldt, Susanne; Stolze, RicardoBackground: Haemophilus influenzae is an opportunistic bacterial pathogen that can cause severe respiratory tract and invasive infections. The emergence of β-lactamase-negative ampicillin-resistant (BLNAR) strains and unclear correlations between genotypic (i.e., gBLNAR) and phenotypic resistance are challenging empirical treatments and patient management. Thus, we sought to revisit molecular resistance mechani...
Haemophilus influenzae Type b Vaccine Failure in Portugal: A Nationwide Multice...
Marques, José Gonçalo; Inácio Cunha, Florbela Maria; Bajanca-Lavado, Maria PaulaBackground: Despite the high effectiveness of the Haemophilus influenzae type b (Hib) vaccine in preventing invasive disease (ID) in children, Hib vaccine failures (VFs) cases may still occur. This study aimed to characterize the Hib-VF cases in Portugal in a 12-year period and trying to identify the possible associated risk factors. Methods: Prospective descriptive nationwide surveillance study. Bacteriologic ...
Sustained increase of paediatric invasive Streptococcus pyogenes infections dom...
Gouveia, Catarina; Bajanca-Lavado, Maria Paula; Mamede, Rafael; Araújo Carvalho, Ana; Rodrigues, Fernanda; Melo-Cristino, José; Ramirez, MarioSince autumn 2022, observed numbers of paediatric invasive group A Streptococcus infections in Portugal (n = 89) were higher than in pre-COVID-19 seasons. Between September 2022 and May 2023, the dominant diagnoses were pneumonia (25/79), mostly with empyema (20/25), and sepsis (22/79). A number of cases required admission to intensive care (27/79) and surgery (35/79), and the case fatality rate was 5.1% (4/79)...
Haemophilus influenzae type b vaccine failure in Portugal: a nationwide multice...
Marques, José; Inácio Cunha, Florbela Maria; Bajanca-Lavado, Maria PaulaBackground: Despite the high effectiveness of the Haemophilus influenzae type b (Hib) vaccine in preventing invasive disease (ID) in children, Hib vaccine failures (VFs) cases may still occur. This study aimed to characterize the Hib-VF cases in Portugal in a 12-year period and trying to identify the possible associated risk factors. Methods: Prospective descriptive nationwide surveillance study. Bacteriologic ...
Sustained increase of paediatric invasive Streptococcus pyogenes infections dom...
Gouveia, Catarina; Bajanca-Lavado, Maria Paula; Mamede, Rafael; Araújo Carvalho, Ana; Rodrigues, Fernanda; Cristino, José Melo; Ramirez, MárioSince autumn 2022, observed numbers of paediatric invasive group A Streptococcus infections in Portugal (n = 89) were higher than in pre-COVID-19 seasons. Between September 2022 and May 2023, the dominant diagnoses were pneumonia (25/79), mostly with empyema (20/25), and sepsis (22/79). A number of cases required admission to intensive care (27/79) and surgery (35/79), and the case fatality rate was 5.1% (4/79)...
Phylogenetic Structure and Comparative Genomics of Multi-National Invasive Haem...
Topaz, Nadav; Tsang, Raymond; Deghmane, Ala-Eddine; Claus, Heike; Lâm, Thiên-Trí; Litt, David; Bajanca-Lavado, Maria Paula; Pérez-Vázquez, MaríaRecent reports have indicated a rise of invasive disease caused by Haemophilus influenzae serotype a (Hia) in North America and some European countries. The whole-genome sequences for a total of 410 invasive Hia isolates were obtained from 12 countries spanning the years of 1998 to 2019 and underwent phylogenetic and comparative genomic analysis in order to characterize the major strains causing disease and the...
Haemophilus influenzae Carriage among Healthy Children in Portugal, 2015-2019
Bajanca-Lavado, Maria Paula; Cavaco, Luís; Fernandes, Mariana; Touret, Tiago; Candeias, Catarina; Simões, Alexandra S.; Sá-Leão, RaquelHaemophilus influenzae is an important cause of mucosal and invasive infections and a common colonizer of the upper respiratory tract. As there are no recent data on H. influenzae carriage in Portugal, we aimed to characterize carriage samples and investigate possible parallelisms with disease isolates. Between 2016–2019, 1524 nasopharyngeal samples were obtained from children (0–6 years) attending day-care. H....
Epidemiology and molecular characterization of invasive disease in children twe...
Bajanca-Lavado, Maria Paula; Bettencout, Célia; Cunha, Florbela; Gonçalo-Marques, JoséBackground: Haemophilus influenzae is an important human pathogen responsible for severe childhood invasive disease, despite the implementation of the vaccine against serotype b isolates (Hib), in our National Immunization Programme (NIP), in June 2000. The use of the vaccine lead to a reduction in Hib invasive disease, together with the emergence of non-encapsulated (NTHi), and capsulated non-b-type isolates. ...
Molecular epidemiology of invasive Haemophilus influenzae disease in Portugal: ...
Heliodoro, Catarina Isabel Moreira; Bettencourt, Célia Rodrigues; Bajanca-Lavado, Maria PaulaHaemophilus influenzae reference laboratory from Portugal characterized the entire collection of 260 H. influenzae invasive isolates received between 2011 and 2018, with the purpose of updating the last published data (2002-2010). Capsular serotypes and antimicrobial susceptibility patterns were determined. The ftsI gene encoding the transpeptidase domain of PBP3 was sequenced for β-lactamase-negative ampicilli...
Spatial and temporal genomic homogeneity among Haemophilus influenzae serotype f
Gonzalez-Diaz, Aida; Pinto, Miguel; Cubero, Meritxell; Langereis, Jeroen D.; van der Ende, Arie; Bajanca-Lavado, Maria Paula; Ardanuy, CarmenBackground: Haemophilus influenzae is an opportunistic pathogen highly adapted to the human respiratory tract which is often reported as the etiologic agent of infectious diseases. After the introduction of serotype b vaccine, non-typeable H. influenzae (NTHi) has become the most frequent cause of respiratory infection, followed in frequency by serotype f strains (Hif). The aim of this study was to analyze the ...