18 documents found, page 1 of 2
Evolution of models of prostate cancer: its contribution to current therapies
Faustino-Rocha, Ana I; Jota-Baptista, C; Gonçalves, E; Oliveira, Paula A.Prostate cancer (PCa) is among the most frequent cancers worldwide. Nowadays, several therapeutic strategies are available for PCa treatment, namely chemotherapy, immunotherapy, radiotherapy, and hormonal therapy. Despite existing therapeutic approaches, in vitro and in vivo models are essential to better understand cancer development and search for more effective therapies, with a positive impact in cancer pat...
The contribution of second primary cancers to the mortality of patients with a ...
Gonçalves, E; Fontes, F; Rodrigues, JR; Calisto, R; Bento, MJ; Lunet, N; Morais, SPurpose: Second primary cancers (SPCs) are estimated to affect nearly 5% of patients with breast cancer within 10 years of their diagnosis. This study aimed to estimate the contribution of SPCs to the mortality of patients with a breast first primary cancer (FPC). Methods: A population-based cohort of 17,210 patients with a breast FPC diagnosed between 2000 and 2010 was followed for SPCs (31/12/2015) and vital ...
Second primary cancers among females with a first primary breast cancer: a popu...
Gonçalves, E; Fontes, F; Rodrigues, JR; Calisto, R; Bento, MJ; Lunet, N; Morais, S"Purpose To estimate the incidence rate of second primary cancers (SPCs) and the cumulative incidence of metachronous [diagnosed > 2 months after a first primary cancer (FPC)] SPCs in patients with a breast FPC, and to compare the incidence of SPC [overall, synchronous (≤ 2 months of the FPC) and metachronous] with that expected in the general female population. Methods A cohort of patients with a breast FPC fr...
COVID-19 vaccines effectiveness against symptomatic disease and severe outcomes...
Brazete, C; Brazete, J; Alves, F; Aguiar, A; Gonçalves, AM; Cardoso, M; Sá, L; Gonçalves, E; Pinto, M; Duarte, RObjectives: This study evaluated the effectiveness of COVID-19 vaccines in preventing symptomatic and severe disease.Study design: This was an observational test-negative case-control study.Methods: Study participants were adults with at least one symptom included in the World Health Or-ganization COVID-19 definition who sought health care in a public emergency department between 1 November 2021 and 2 March 202...
Imipenem-Relebactam Susceptibility in Enterobacterales Isolates Recovered from ...
Hernández-García, M; García-Castillo, M; Bou, G; Cercenado, E; Delgado-Valverde, M; Oliver, A; Pitart, C; Rodríguez-Lozano, J; Tormo, NImipenem-relebactam is a novel β-lactam-β-lactamase inhibitor combination. We evaluated the in vitro activity of imipenem-relebactam and comparators against Enterobacterales clinical isolates recovered in 8 Spanish and 11 Portuguese intensive care units (ICUs) (SUPERIOR, 2016-2017; STEP, 2017-2018). Overall, 747 Enterobacterales isolates (378 Escherichia coli, 252 Klebsiella spp., 64 Enterobacter spp., and 53 o...
Risk and Survival of Third Primary Cancers in a Population-Based Cohort of Brea...
Morais, S; Gonçalves, E; Fontes, F; Rodrigues, J; Calisto, R; Bento, MJ; Lunet, NIntroduction: The growing number of women diagnosed with breast cancer (BCa) together with high survival has resulted in an increasing population of survivors at risk of subsequent primary cancers. This study aimed to estimate the long-term risk and survival of third primary cancers (TPCs) among females with a first primary BCa. Methods: Breast first primary cancers (FPCs) from the Portuguese North Region Cance...
Confronting Ceftolozane-Tazobactam Susceptibility in Multidrug-Resistant Entero...
Hernández-García, M; García-Fernández, S; García-Castillo, M; Melo-Cristino, J; Pinto, M; Gonçalves, E; Alves, V; Costa, E; Ramalheira, E; Sancho, LCeftolozane-tazobactam (C/T) is frequently used for infections caused by multidrug-resistant (MDR)-Enterobacterales isolates. Whole-genome sequencing (WGS, Illumina-Hiseq 4000/NovaSeq 6000, OGC, UK) was used to study the population structure, the resistome and the virulome of C/T-susceptible and -resistant MDR Escherichia spp. (n=30) and Klebsiella spp. (n=78) isolates, recovered from lower respiratory, intra-a...
In Vitro Activity of Ceftolozane-Tazobactam Against Enterobacterales and Pseudo...
García-Fernández, S; García-Castillo, M; Melo-Cristino, J; Pinto, M; Gonçalves, E; Alves, V; Vieira, AR; Ramalheira, E; Sancho, L, et al.The STEP surveillance study was designed to increase knowledge about distribution of multidrug-resistant (MDR) Enterobacterales and Pseudomonas aeruginosa in Portugal, focusing on the intensive care unit (ICU). Antimicrobial susceptibility of common agents was also evaluated and compared with that of one of the latest therapeutic introductions, ceftolozane-tazobactam (C/T). Clinical isolates of Enterobacterales...
In Vitro Activity of Ceftolozane-Tazobactam Against Enterobacterales and Pseudo...
García-Fernández, S; García-Castillo, M; Melo-Cristino, J; Pinto, M; Gonçalves, E; Alves, V; Vieira, AR; Ramalheira, E; Sancho, L; Diogo, J; Ferreira, RThe STEP surveillance study was designed to increase knowledge about distribution of multidrug-resistant (MDR) Enterobacterales and Pseudomonas aeruginosa in Portugal, focusing on the intensive care unit (ICU). Antimicrobial susceptibility of common agents was also evaluated and compared with that of one of the latest therapeutic introductions, ceftolozane-tazobactam (C/T). Clinical isolates of Enterobacterales...
Dossier: Praticar exercício físico em ambiente frio
Ribeiro, B; Marques, JP; Rêgo, C; Dores, H; Bragança, M; Moreira, A; Jones, H; Gonçalves, E; Merino, FA prática de exercício físico em condições atmosféricas adversas (excesso de calor ou de frio, de vento ou de humi- dade, sob chuva) exige do corpo humano adaptações permanentes no sentido de manter a homeostasia interna e o rendimento desportivo desejado. O desafio ao corpo humano aumenta ainda com a altitude muito elevada e no que se refere ao ambiente frio é diferente se desporto é praticado dentro ou fora d...