20 documents found, page 1 of 2
Risk of colonization with multidrug-resistant gram-negative bacteria among trav...
Pedro, Diogo; Santos, Daniela; Meneses, Maria; Gonçalves, Fátima; Jantarada Domingos, Gonçalo; Caneiras, CatiaGlobalization in the 21st century has posed several challenges. In particular, the spread of multidrug-resistant bacterial strains, especially Gram-negative bacteria, which are prevalent in certain regions of the world, is one of the most critical issues. This raises concerns about the risks associated with the booming tourism industry and migratory flows. In fact, even transient colonization with multidrug-res...
HIV-1 diversity and pre-treatment drug resistance in the era of integrase inhib...
Sebastião, Cruz S.; Abecasis, Ana B.; Jandondo, Domingos; Sebastião, Joana M.; Vigário, João; Comandante, Felícia; Pingarilho, Marta; Pocongo, BárbaraThe surveillance of drug resistance in the HIV-1 naïve population remains critical to optimizing the effectiveness of antiretroviral therapy (ART), mainly in the era of integrase strand transfer inhibitor (INSTI) regimens. Currently, there is no data regarding resistance to INSTI in Angola since Dolutegravir-DTG was included in the first-line ART regimen. Herein, we investigated the HIV-1 genetic diversity and ...
High instantaneous inhibitory potential of Bictegravir and the new Spiro-β-Lact...
Bártolo, Inês; Moranguinho, Inês; Gonçalves, Paloma; Diniz, Ana Rita; Borrego, Pedro; Martin, Francisco; Figueiredo, Inês; Gomes, PerpétuaIntegrase inhibitors (INIs) are an important class of drugs for treating HIV-2 infection, given the limited number of drugs active against this virus. While the clinical efficacy of raltegravir and dolutegravir is well established, the clinical efficacy of bictegravir for treating HIV-2 infected patients has not been determined. Little information is available regarding the activity of bictegravir against HIV-2...
Management of HIV-2 resistance to antiretroviral therapy in a HIV-1/HIV-2/HBV c...
Cardoso, Margarida; Vasconcelos, Joana; Baptista, Teresa; Diogo, Isabel; Gonçalves, Fátima; Mansinho, Kamal; Gomes, PerpétuaBackground: The current standard of care is to start antiretroviral therapy in all patients diagnosed with HIV-1, as for HIV-2 current DHHS guideline suggests ART for HIV-2 as soon as diagnosis is established, although this practice is not universal, for instance, in Portugal there are specific criteria to start treatment. Case presentation: We present a case of a man, chronically infected with HIV-1, HIV-2 and...
Do soil management practices affect the activity density, diversity, and stabil...
Gonçalves, Fátima; Nunes, Cátia; Carlos, Cristina; López, Álvaro; Oliveira, Irene; Crespí, António; Teixeira, Branca; Pinto, RuiArthropods are important components of the soil fauna in improving soil quality and its structural properties. Arthropods are also very sensitive to soil management practices. Thus, a study was carried out in a vineyard in the Douro Demarcated Region (Northeast Portugal), to investigate the effect of three soil management practices (tillage, ground cover with spontaneous vegetation, and ground cover with sown v...
Capnothorax During Laparoscopy in Trendelenburg Position: A Rare Case Study
Damas, Ana Margarida; Gonçalves, Fátima; Antunes, Marisa; Barata, SóniaPneumothorax is an infrequent complication of laparoscopic surgery. Most cases occur during upper abdominal surgery, since a head-down position (Trendelenburg) pushes the liver and peritoneum against the diaphragm, reducing gas release. When it is due to CO2 diffusion across congenital diaphragmatic defects, it usually resolves itself spontaneously after de-insufflation of the pneumoperitoneum. Increasing posit...
DESIGN AND DEVELOPMENT OF A SERIOUS GAME TO FIGHT CHILDHOOD OBESITY
Gonçalves, Fátima; Carvalho, Vítor; Matos, DemétrioAccording to World Health Organization, childhood obesity, classified as the epidemic of the 21st century, is reaching alarming values all over the world. Mobile technologies, especially smartphones and tablets, are an important part of a children’s life. Many studies believe that these technologies can be used in a healthy way, helping children to grow, so caregivers allow its use, on the hope that can help at...
Biodiversidade do solo em vinhas com e sem enrelvamento
Nunes, Cátia; Teixeira, Branca; Carlos, Cristina; Gonçalves, Fátima; Martins, Mónica; Crespí, António; Sousa, Susana; Torres, LauraO presente trabalho realizado no âmbito do projecto “EcoVitis: Maximização dos Serviços do Ecossistema Vinha na Região Demarcada do Douro” teve por objectivo avaliar a influência do enrelvamento natural, enrelvamento semeado e mobilização na entrelinha, na diversidade dos artrópodes do solo na vinha. A parte experimental decorreu na Quinta do Casal da Granja, propriedade da Real Companhia Velha. Procedeu-se ao ...
Genotypic resistance profiles of HIV-2 infected patients from Cape Verde failin...
Moranguinho, Inês; Borrego, Pedro; Gonçalves, Fátima; Gomes, Perpétua; Rocha, José; Barreto, Jorge; Taveira, NunoThe pol gene from HIV-2 infected patients from Cape Verde experiencing virologic failure was sequenced and drug resistance mutations were determined. Most patients were taking a first line regimen of AZT, 3TC and LPV/r. Resistance mutations were found in most patients (11/17, 64.7%) especially I82F (4/7, 57.1%) and M184 V (10/17, 58.8%). Resistance to all reverse transcriptase and protease inhibitors was found ...
In vitro evaluation of novel reverse transcriptase inhibitors TAF (tenofovir al...
Bártolo, Inês; Borrego, Pedro; Gomes, Perpétua; Gonçalves, Fátima; Caixas, Umbelina; Pinto, Inês V.; Taveira, NunoNew antiretroviral drugs are needed to treat HIV-2 infected patients failing therapy. Herein, we evaluate the activity of novel reverse transcriptase inhibitors tenofovir alafenamide (TAF) and OBP-601(2,3-didehydro-3-deoxy-4-ethynylthymidine) against primary isolates from HIV-2 infected patients experiencing virologic failure. TAF and OBP-601 were tested against twelve primary isolates obtained from nine drug-e...