15 documents found, page 1 of 2
Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Ade...
Dias, Liliana; Pochmann, Daniela; Lemos, Cristina; Silva, Henrique B.; Real, Joana I.; Gonçalves, Francisco Q.; Rial, Daniel; Gonçalves, NélioIncreased ATP release and its extracellular catabolism through CD73 (ecto-5'-nucleotidase) lead to the overactivation of adenosine A2A receptors (A2AR), which occurs in different brain disorders. A2AR blockade blunts mood and memory dysfunction caused by repeated stress, but it is unknown if increased ATP release coupled to CD73-mediated formation of extracellular adenosine is responsible for A2AR overactivatio...
Adenosine A2A Receptors Shut Down Adenosine A1 Receptor-Mediated Presynaptic In...
Lopes, Cátia R.; Gonçalves, Francisco Q.; Olaio, Simão; Tomé, Ângelo R.; Cunha, Rodrigo A.; Lopes, João PedroAdenosine operates a modulation system fine-tuning the efficiency of synaptic transmission and plasticity through A1 and A2A receptors (A1R, A2AR), respectively. Supramaximal activation of A1R can block hippocampal synaptic transmission, and the tonic engagement of A1R-mediated inhibition is increased with increased frequency of nerve stimulation. This is compatible with an activity-dependent increase in extrac...
Increased ATP Release and Higher Impact of Adenosine A2A Receptors on Corticost...
Gonçalves, Francisco Q.; Matheus, Filipe C.; Silva, Henrique B.; Real, Joana I.; Rial, Daniel; Rodrigues, Ricardo J.; Oses, Jean-PierreExtracellular ATP can be a danger signal, but its role in striatal circuits afflicted in Parkinson's disease (PD) is unclear and was now investigated. ATP was particularly released at high stimulation intensities from purified striatal nerve terminals of mice, which were endowed with different ATP-P2 receptors (P2R), although P2R antagonists did not alter corticostriatal transmission or plasticity. Instead, ATP...
Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potenti...
Lopes, Cátia R.; Silva, Joana S; Santos, Joana; Rodrigues, Matilde S.; Madeira, Daniela; Oliveira, Andreia; Moreira-de-Sá, Ana; Lourenço, Vanessa S.Alzheimer's disease (AD), which predominantly affects women, involves at its onset a metabolic deregulation associated with a synaptic failure. Here, we performed a behavioral, neurophysiological and neurochemical characterization of 9-month-old female APPswe/PS1dE9 (APP/PS1) mice as a model of early AD. These animals showed learning and memory deficits in the Morris water maze, increased thigmotaxis and anxiet...
Increased ATP release and CD73-mediated adenosine A2A receptor activation media...
Augusto, Elisabete de Oliveira; Gonçalves, Francisco Q.; Real, Joana E.; Silva, Henrique B.; Pochmann, Daniela; Silva, Tiago S.; Matos, MarcoExtracellular ATP is a danger signal to the brain and contributes to neurodegeneration in animal models of Alzheimer's disease through its extracellular catabolism by CD73 to generate adenosine, bolstering the activation of adenosine A2A receptors (A2AR). Convulsive activity leads to increased ATP release, with the resulting morphological alterations being eliminated by A2AR blockade. However, it is not known i...
Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory ...
Fernandes, Mara Yone D.; Dobrachinski, Fernando; Silva, Henrique B.; Lopes, João Pedro; Gonçalves, Francisco Q.; Soares, Felix A AThe increased healthspan afforded by coffee intake provides novel opportunities to identify new therapeutic strategies. Caffeine has been proposed to afford benefits through adenosine A2A receptors, which can control synaptic dysfunction underlying some brain disease. However, decaffeinated coffee and other main components of coffee such as chlorogenic acids, also attenuate brain dysfunction, although it is unk...
Crosstalk Between ATP-P2X7 and Adenosine A2A Receptors Controlling Neuroinflamm...
Dias, Liliana; Lopes, Cátia R.; Gonçalves, Francisco Q.; Nunes, Ana R.; Pochmann, Daniela; Machado, Nuno J.; Tomé, Ângelo R.; Agostinho, PaulaDepressive conditions precipitated by repeated stress are a major socio-economical burden in Western countries. Previous studies showed that ATP-P2X7 receptors (P2X7R) and adenosine A2A receptors (A2AR) antagonists attenuate behavioral modifications upon exposure to repeated stress. Since it is unknown if these two purinergic modulation systems work independently, we now investigated a putative interplay betwee...
Adenosine A2A receptors format long-term depression and memory strategies in a ...
Moreira-de-Sá, Ana; Gonçalves, Francisco Q.; Lopes, João P.; Silva, Henrique B.; Tomé, Ângelo R.; Cunha, Rodrigo A.; Canas, PaulaAngelman syndrome (AS) is a neurodevelopmental disorder caused by loss of function of the maternally inherited Ube3a neuronal protein, whose main features comprise severe intellectual disabilities and motor impairments. Previous studies with the Ube3am-/p+ mouse model of AS revealed deficits in synaptic plasticity and memory. Since adenosine A2A receptors (A2AR) are powerful modulators of aberrant synaptic plas...
Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Tr...
Canas, Paula M.; Porciúncula, Lisiane O.; Simões, Ana Patrícia; Augusto, Elisabete de Oliveira; Silva, Henrique B.; Machado, Nuno J.; Gonçalves, NélioNeurodegeneration is a process transversal to neuropsychiatric diseases and the understanding of its mechanisms should allow devising strategies to prevent this irreversible step in brain diseases. Neurodegeneration caused by seizures is a critical step in the aggravation of temporal lobe epilepsy, but its mechanisms remain undetermined. Convulsions trigger an elevation of extracellular adenosine and upregulate...
Elevated Pressure Changes the Purinergic System of Microglial Cells
Rodrigues-Neves, Ana C.; Aires, Inês D.; Vindeirinho, Joana R.; Boia, Raquel; Madeira, Maria H.; Gonçalves, Francisco Q.; Cunha, Rodrigo A.Glaucoma is the second cause of blindness worldwide and is characterized by the degeneration of retinal ganglion cells (RGCs) and optic nerve atrophy. Increased microglia reactivity is an early event in glaucoma that may precede the loss of RGCs, suggesting that microglia and neuroinflammation are involved in the pathophysiology of this disease. Although global changes of the purinergic system have been reporte...