32 documents found, page 1 of 4
Concurrent Binary Search Tree
Gonçalves, Hugo; Shirley, PauloThis article proposes the implementation of a library in C language for a Binary Search Tree, where several concurrency control methods are offered for the most common operations performed in this data structure. An analysis of the gains or losses of each method in several replicable scenarios is presented.; Este artigo propõe a implementação de uma biblioteca em linguagem C para uma Árvore de Pesquisa Binária ...
Árvore de pesquisa binária concorrente
Gonçalves, Hugo; Shirley, PauloEste artigo propõe a implementação de uma biblioteca em linguagem C para uma Árvore de Pesquisa Binária (Binary Search Tree), onde se oferecem diversos métodos de controlo de concorrência para as operações mais comuns efetuadas nesta estrutura de dados. É apresentada uma análise sobre os ganhos ou perdas de cada método para diversos cenários replicáveis de utilização da árvore.
Nanostructured lipid carriers enriched hydrogels for skin topical administratio...
Lúcio, Marlene; Giannino, Nicole; Barreira, Sérgio; Catita, José; Gonçalves, Hugo; Ribeiro, Artur; Fernandes, Eduarda; Carvalho, Isabel; Pinho, HugoChronic skin exposure to external hostile agents (e.g., UV radiation, microorganisms, and oxidizing chemicals) may increase oxidative stress, causing skin damage and aging. Because of their well-known skincare and protective benefits, quercetin (Q) and omega-3 fatty acids (ω3) have attracted the attention of the dermocosmetic and pharmaceutical sectors. However, both bioactives have inherent properties that lim...
Riluzole-loaded lipid nanoparticles for brain delivery: preparation, optimizati...
Teixeira, Maria Inês; Lopes, Carla Martins; Gonçalves, Hugo; Catita, José; Silva, Ana Margarida; Rodrigues, Francisca; Amaral, Maria HelenaAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, with a median survival of only 2 to 4 years. Riluzole, a drug commonly used in the management of ALS, has a low aqueous solubility and limited bioavailability. ALS treatment is also hindered by the presence of the blood–brain barrier (BBB) that preserves the delicate homeostasis of the cerebral milieu, isolating it and making brain drug d...
Engineering ligament scaffolds based on PLA/graphite nanoplatelet composites by...
Silva, Magda Sofia Gonçalves; Pinho, Isabel; Gonçalves, Hugo; Vale, Ana C.; Paiva, Maria C.; Alves, Natália M.; Covas, J. A.The development of scaffolds for tissue-engineered growth of the anterior cruciate ligament (ACL) is a promising approach to overcome the limitations of current solutions. This work proposes novel biodegradable and biocompatible scaffolds matching the mechanical characteristics of the native human ligament. Poly(L-lactic acid) (PLA) scaffolds reinforced with graphite nano-platelets (PLA+EG) as received, chemica...
Nanostructured lipid carriers enriched hydrogels for skin topical administratio...
Lúcio, M.; Giannino, Nicole; Barreira, Sérgio; Catita, José; Gonçalves, Hugo; Ribeiro, Artur; Fernandes, Eduarda; Carvalho, Isabel; Pinho, HugoChronic skin exposure to external hostile agents (e.g., UV radiation, microorganisms, and oxidizing chemicals) may increase oxidative stress, causing skin damage and aging. Because of their well-known skincare and protective benefits, quercetin (Q) and omega-3 fatty acids (ω3) have attracted the attention of the dermocosmetic and pharmaceutical sectors. However, both bioactives have inherent properties that lim...
The Portuguese Large Wildfire Spread database (PT-FireSprd)
Benali, Akli; Guiomar, Nuno; Gonçalves, Hugo; Mota, Bernardo; Silva, Fábio; Fernandes, Paulo M.; Mota, Carlos; Penha, Alexandre; Santos, JoãoWildfire behaviour depends on complex interactions between fuels, topography, and weather over a wide range of scales, being important for fire research and management applications. To allow for significant progress towards better fire management, the operational and research communities require detailed open data on observed wildfire behaviour. Here, we present the Portuguese Large Wildfire Spread database (PT...
Formulation, characterization, and cytotoxicity evaluation of lactoferrin funct...
Teixeira, Maria Inês; Lopes, Carla Martins; Gonçalves, Hugo; Catita, José; Silva, Ana Margarida; Rodrigues, Francisca; Amaral, Maria HelenaAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a very poor prognosis. Its treatment is hindered by a lack of new therapeutic alternatives and the existence of the blood–brain barrier (BBB), which restricts the access of drugs commonly used in ALS, such as riluzole, to the brain. To overcome these limitations and increase brain targeting, riluzole-loaded nanostructured lipid carriers (NL...
Personalised esomeprazole and ondansetron 3D printing formulations in Hospital ...
Ferreira, Mariana; Lopes, Carla Martins; Gonçalves, Hugo; Pinto, João F.; Catita, JoséIndividualised medicine demands the formulation of pharmacotherapy in accordance with the characteristics of each patient’s health condition, and paediatrics is one of the areas that needs this approach. The 3D printing of oral doses is one method for achieving customised medicine in paediatrics. In this work, pre-formulation studies were conducted to evaluate the viability of using specific raw materials to pr...
Formulation, Characterization, and Cytotoxicity Evaluation of Lactoferrin Funct...
Teixeira, Maria Inês; Lopes, Carla Martins; Gonçalves, Hugo; Catita, José; Silva, Ana Margarida; Rodrigues, Francisca; Amaral, Maria HelenaAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a very poor prognosis. Its treatment is hindered by a lack of new therapeutic alternatives and the existence of the blood–brain barrier (BBB), which restricts the access of drugs commonly used in ALS, such as riluzole, to the brain. To overcome these limitations and increase brain targeting, riluzole-loaded nanostructured lipid carriers (NL...