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Magnetoliposomes containing multicore nanoparticles and a new antitumor thienop...
Lopes, Fábio A. C.; Fernandes, André V. F.; Rodrigues, Juliana M.; Queiroz, Maria João R. P.; Almeida, B. G.; Pires, Ana; Pereira, André M.Multicore magnetic nanoparticles of manganese ferrite were prepared using carboxymethyl dextran as an agglutinating compound or by an innovative method using melamine as a cross-coupling agent. The nanoparticles prepared using melamine exhibited a flower-shape structure, a saturation magnetization of 6.16 emu/g and good capabilities for magnetic hyperthermia, with a specific absorption rate (SAR) of 0.14 W/g. M...
Development of thermo-and pH-sensitive liposomal magnetic carriers for new pote...
Ribeiro, Beatriz C.; Alvarez, Cristina A.R.; Alves, Bárbara C.; Rodrigues, Juliana M.; Queiroz, Maria João R. P.; Almeida, B. G.; Pires, AnaThe development of stimuli-sensitive drug delivery systems is a very attractive area of current research in cancer therapy. The deep knowledge on the microenvironment of tumors has supported the progress of nanosystems’ ability for controlled and local fusion as well as drug release. Temperature and pH are two of the most promising triggers in the development of sensitive formulations to improve the efficacy of...
Magnetoliposomes based on magnetic/plasmonic nanoparticles loaded with tricycli...
Rio, Irina Soraia Rainho; Rodrigues, Ana Rita Oliveira; Rodrigues, Juliana M.; Queiroz, Maria João R. P.; Calhelha, R. C.; Ferreira, Isabel C. F. R.Liposome-like nanoarchitectures containing manganese ferrite nanoparticles covered or decorated with gold were developed for application in dual cancer therapy, combining chemotherapy and photothermia. The magnetic/plasmonic nanoparticles were characterized using XRD, UV/Visible absorption, HR-TEM, and SQUID, exhibiting superparamagnetic behavior at room temperature. The average size of the gold-decorated nanop...
Synthesis of Novel Methyl 3-(hetero)arylthieno[3,2-b]pyridine-2-carboxylates an...
Silva, Bruna R.; Rebelo, Rita; Rodrigues, Juliana M.; Xavier, Cristina P. R.; Vasconcelos, M. Helena; Queiroz, Maria João R. P.A series of novel functionalized methyl 3-(hetero)arylthieno[3,2-<i>b</i>]pyridine-2-carboxylates <b>2a</b>–<b>2h</b> were synthesized by C-C Pd-catalyzed Suzuki-Miyaura cross-coupling of methyl 3-bromothieno[3,2-<i>b</i>]pyridine-2-carboxylate with (hetero)aryl pinacol boranes, trifluoro potassium boronate salts or boronic acids. Their antitumoral potential was evaluated in two triple negative breast cancer (T...
Synthesis of novel methyl 7-[(hetero)arylamino]thieno[2,3-b] pyrazine-6-carboxy...
Rodrigues, Juliana M.; Calhelha, Ricardo C.; Nogueira, António; Ferreira, Isabel C. F. R.; Barros, Lillian; Queiroz, Maria João R. P.Several novel methyl 7-[(hetero)arylamino]thieno[2,3-<i>b</i>]pyrazine-6-carboxylates were synthesized by Pd-catalyzed C–N Buchwald–Hartwig cross-coupling of either methyl 7-aminothieno[3,2-<i>b</i>]pyrazine-6-carboxylate with (hetero)arylhalides or 7-bromothieno[2,3-<i>b</i>]pyrazine-6-carboxylate with (hetero)arylamines in good-to-excellent yields (50% quantitative yield), using different reaction conditions,...
Magnetic/plasmonic liposomes as nanocarriers for novel antitumor tricyclic lact...
Rodrigues, Ana Rita Oliveira; Rio, Irina Soraia Rainho; Rodrigues, J. M.; Queiroz, Maria João R. P.; Calhelha, Ricardo C.; Ferreira, Isabel C. F. R.In this work, MnFe2O4/Au core/shell nanoparticles (NPs) and MnFe2O4 NPs decorated with Au NPs were synthesized and the structural, spectroscopic and magnetic properties evaluated. The prepared NPs were covered with a lipid bilayer, forming solid magnetoliposomes (SMLs). The heating capabilities of the nanosystems were assessed through the fluorescence quenching of Nile Red (incorporated in the lipid bilayer of ...
Development of multifunctional liposomes containing magnetic/plasmonic MnFe2O4/...
Rodrigues, Ana Rita Oliveira; Matos, Joana O. G.; Dias, Armando M. Nova; Almeida, B. G.; Pires, Ana; Pereira, André M.; Araújo, João P.Multifunctional liposomes containing manganese ferrite/gold core/shell nanoparticles were developed. These magnetic/plasmonic nanoparticles were covered by a lipid bilayer or entrapped in liposomes, which form solid or aqueous magnetoliposomes as nanocarriers for simultaneous chemotherapy and phototherapy. The core/shell nanoparticles were characterized by UV/Visible absorption, X-Ray Diffraction (XRD), Transmi...
Novel dehydropeptide-based magnetogels containing manganese ferrite nanoparticl...
Veloso, Sérgio Rafael Silva; Magalhães, Carlos A. B.; Rodrigues, Ana Rita Oliveira; Vilaça, Maria Helena Pereira; Queiroz, Maria João R. P.Herein, novel dehydropeptide-based magnetogels, based on the hydrogelators Npx-L-Phe-Z-ΔAbu-OH, Npx-L-Trp-Z-ΔPhe-OH and Npx-L-Ala-Z-ΔPhe-Gly-L-Arg-Gly-L-Asp-Gly-OH and containing manganese ferrite nanoparticles (diameters around 20 nm), were prepared and characterized. TEM and FTIR measurements showed that the magnetogels maintained the fibrous structure of neat hydrogels, with fibres of ca. 20 nm average width...
Magnetoliposomes containing calcium ferrite nanoparticles for applications in b...
Pereira, Daniela S. M.; Cardoso, Beatriz D.; Rodrigues, Ana Rita O.; Amorim, Carlos O.; Amaral, Vítor S.; Almeida, B. G.; Queiroz, Maria João R. P.Magnetoliposomes containing calcium ferrite (CaFe<sub>2</sub>O<sub>4</sub>) nanoparticles were developed and characterized for the first time. CaFe<sub>2</sub>O<sub>4 </sub>nanoparticles were covered by a lipid bilayer or entrapped in liposomes forming, respectively, solid or aqueous magnetoliposomes as nanocarriers for new antitumor drugs. The magnetic nanoparticles were characterized by UV/Visible absorption,...
Solid magnetoliposomes entrapping new potential antitumor drugs for application...
Ferreira, João M. C.; Rodrigues, Juliana M.; Rodrigues, Ana Rita Oliveira; Coutinho, Paulo J. G.; Castanheira, Elisabete M. S.In this work, new solid magnetoliposomes (nanoparticle aggregates covered by a lipid/surfactant bilayer), containing manganese ferrite nanoparticles, have been developed. For that, a first layer of octadecylamine (ODA) was covalently linked to the nanoparticles surface and then covered by a layer of the phospholipid DPPC (second layer). These nanosystems exhibit diameters below 150 nm and the capability to inte...