13 documents found, page 1 of 2
Placental microphysiological systems: new advances on promising platforms that ...
Gonçalves, Inês M.; Afzal, Muhammad; Kennedy, Nithil; Moita, Ana; Lima, Rui Alberto Madeira Macedo; Ostrovidov, Serge; Hori, Takeshi; Nashimoto, YujiOne of the most complex human physiological processes to study is pregnancy. Standard animal models, as well as two-dimensional models, lack the complexity and biological relevance required to accurately study such a physiological process. Recent studies have focused on the development of three-dimensional models based on microfluidic systems, designated as placental microphysiological systems (PMPSs). PMPS dev...
Numerical evaluation and experimental validation of fluid flow behavior within ...
Carvalho, Violeta Meneses; Gonçalves, Inês M.; Rodrigues, Nelson; Sousa, Paulo; Pinto, Vânia; Minas, Graça; Kaji, Hirokazu; Shin, Su RyonBy combining biomaterials, cell culture, and microfluidic technology, organ-on-a-chip (OoC) platforms have the ability to reproduce the physiological microenvironment of human organs. For this reason, these advanced microfluidic devices have been used to resemble various diseases and investigate novel treatments. In addition to the experimental assessment, numerical studies of biodevices have been performed aim...
Recent developments on the thermal properties, stability and applications of na...
Nobrega, Glauco Tapijara Vallicelli; Souza, Reinaldo Rodrigues de; Gonçalves, Inês M.; Moita, Ana S.; Ribeiro, J.E.; Lima, Rui A.In this review work, the recent progress made in the use of nanofluids (NFs) applied in three specific areas will be presented: machining, solar energy, and biomedical engineering. Within this context, the discussions will be guided by emphasizing the thermal and stability properties of these fluids. In machining, NFs play a prominent role in the processes of turning, milling, drilling, and grinding, being resp...
Recent advances on the thermal properties and applications of nanofluids: from ...
Souza, Reinaldo Rodrigues; Gonçalves, Inês M.; Rodrigues, Raquel Oliveira; Minas, Graça; Miranda, J. M.; Moreira, António L. N.The nanofluids (NFs) are known as a colloidal suspension where nanoparticles (NPs) are dispersed in conventional base fluids (BFs). This suspension has been frequently used to augment the heat transfer (HT) capacity of a fluid by studying their thermophysical properties. This review outlines the most recent advances on the NFs thermal properties and on their applications that are being used in different fields ...
Recent developments on the thermal properties, stability and applications of na...
Nobrega, Glauco; Souza, Reinaldo Rodrigues; Gonçalves, Inês M.; Moita, Ana S.; Ribeiro, João E.; Lima, Rui Alberto Madeira MacedoIn this review work, the recent progress made in the use of nanofluids (NFs) applied in three specific areas will be presented: machining, solar energy, and biomedical engineering. Within this context, the discussions will be guided by emphasizing the thermal and stability properties of these fluids. In machining, NFs play a prominent role in the processes of turning, milling, drilling, and grinding, being resp...
A review of the advances and challenges in measuring the thermal conductivity o...
Souza, Reinaldo Rodrigues; Faustino, Vera; Gonçalves, Inês M.; Moita, Ana S.; Bañobre-López, Manuel; Lima, Rui Alberto Madeira MacedoFluids containing colloidal suspensions of nanometer-sized particles (nanofluids) have been extensively investigated in recent decades with promising results. Driven by the increase in the thermal conductivity of these new thermofluids, this topic has been growing in order to improve the thermal capacity of a series of applications in the thermal area. However, when it comes to measure nanofluids (NFs) thermal ...
Experimental characterization of a microfluidic device based on passive crossfl...
Gonçalves, Inês M.; Castro, Inês; Barbosa, Filipe; Faustino, Vera; Catarino, Susana Oliveira; Moita, Ana; Miranda, João M.; Minas, GraçaThe separation of red blood cells (RBCs) from blood plasma and the analysis of individual RBCs are of great importance, as they provide valuable information regarding the health of their donor. Recent developments in microfluidics and microfabrication have contributed to the fabrication of microsystems with complex features to promote the separation and analysis of RBCs. In this work, the separation capacity of...
Recent trends of biomaterials and biosensors for organ-on-chip platforms
Gonçalves, Inês M.; Rodrigues, Raquel Oliveira; Moita, Ana S.; Hori, Takeshi; Kaji, Hirokazu; Lima, Rui Alberto Madeira Macedo; Minas, GraçaOrgan-on-chip (OoC) platforms are a new class of advanced microfluidic devices that have been attracting significant attention for drug development since they can allow a faster and more patient specific evaluation of the effects of drugs due to the mimicking of organ human models. As most microfluidic devices, the great majority of the OoC is made from polydimethylsiloxane (PDMS), due to the easiness to handle...
Manual and automatic image analysis segmentation methods for blood flow studies...
Carvalho, Violeta Meneses; Gonçalves, Inês M.; Souza, Andrews Victor Almeida; Souza, Maria Sabrina; Bento, David; Ribeiro, J.E.; Lima, Rui A.In blood flow studies, image analysis plays an extremely important role to examine raw data obtained by high-speed video microscopy systems. This work shows different ways to process the images which contain various blood phenomena happening in microfluidic devices and in microcirculation. For this purpose, the current methods used for tracking red blood cells (RBCs) flowing through a glass capillary and techni...
A novel and extremely stable nanofluid based on iron oxide nanoparticles: Exper...
Souza, R. R.; Faustino, Vera; Oliveira, J. D.; Gonçalves, Inês M.; Miranda, João M.; Moita, Ana S.; Moreira, A. L. N.; Teixeira, José C. F.The analysis of the thermal conductivity of nanofluids (NFs) is extremely important to better understand the heat transfer mechanisms involved in the performance and efficiency of several thermal devices. In this work, two different NFs were tested using distilled water (DI-Water) as the base fluid. The first was a traditional NF formed by Al2O3 nanoparticles (NPs) and the second was a novel NF formed by polyac...