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Ingested titanium dioxide nanomaterials: new approach to investigate intestinal...
Ventura, Célia; Rolo, Dora; Gramacho, Ana C.; Vieira, Adriana; Roque, Rossana; Valente, Ana; Vital, Nádia; Pinto, Fátima; Alvito, PaulaOral exposure to titanium dioxide nanomaterials (TiO2NMs) is due to their presence in food, food contact materials, medicines and cosmetics. The gastrointestinal tract(GIT) represents primary site of contact, that may result in systemic exposure, if biological barriers are surpassed. The INGESTnano project aimed to investigate nano-bio interactions at the cellular/molecular levels within the context of the inte...
Assessing the impact of TiO2 nanomaterials on intestinal cells: New evidence fo...
Rolo, Dora; Pereira, Joana F.S.; Gonçalves, Lídia; Bettencourt, Ana; Jordan, Peter; Silva, Maria João; Matos, Paulo; Louro, HenriquetaUnderstanding the potential impact of nanomaterials (NMs) on human health requires further investigation into the organ-specific nano-bio interplay at the cellular and molecular levels. We showed increased chromosomal damage in intestinal cells exposed to some of in vitro digested Titanium dioxide (TiO2) NMs. The present study aimed to explore possible mechanisms linked to the uptake, epithelial barrier integri...
Development of a chlorhexidine delivery system based on dental reline acrylic r...
Bettencourt, Ana; Costa, Joana; Ribeiro, Isabel A. C.; Gonçalves, Lídia; Arias-Moliz, Maria Teresa; Dias, Juliana R.; Franco, Margarida; Alves, Nuno M.The high recurrence rate of common denture stomatitis after antifungal treatment is still concerning. This condition is caused by low patient compliance and incomplete local elimination of the main etiological factor — Candida albicans, often associated with other microorganisms, such as Streptococcus species. Impregnating denture materials with antimicrobials for local delivery is a strategy that can overcome ...
Design, Evaluation and Comparison of Nanostructured Lipid Carriers and Chitosan...
Nerli, Giulia; Gonçalves, Lídia; Cirri, Marzia; Almeida, António José; Maestrelli, Francesca; Mennini, Natascia; Mura, PaolaThere is a serious need of pediatric drug formulations, whose lack causes the frequent use of extemporaneous preparations obtained from adult dosage forms, with consequent safety and quality risks. Oral solutions are the best choice for pediatric patients, due to administration ease and dosage-adaptability, but their development is challenging, particularly for poorly soluble drugs. In this work, chitosan nanop...
Topical ocular delivery of nanoparticles with epoetin beta in Wistar Hannover rats
Silva, Beatriz; Gonçalves, Lídia; Braz, Berta São; Delgado, EsmeraldaTopical instillation of drugs targeting the posterior ocular segment is an expanding area of research. Chitosan and hyaluronic acid have remarkable mucoadhesive properties and potentially enhance pre-corneal retention time after topical instillation. Bearing this in mind, we explored the possibility of delivering epoetin beta (EPOβ) to the posterior segment of the eye in a chitosan-hyaluronic acid (CS/HA-EPOβ) ...
Infliximab microencapsulation: an innovative approach for intra-articular admin...
Lamela-Gómez, Iván; Gonçalves, Lídia; Almeida, António José; Luzardo-Álvarez, AsteriaMicroencapsulation of the therapeutical monoclonal antibody infliximab (INF) was investigated as an innovative approach to improve its stability and to achieve formulations with convenient features for intra-articular administration. Ultrasonic atomization (UA), a novel alternative to microencapsulate labile drugs, was compared with the conventional emulsion/evaporation method (Em/Ev) using biodegradable polyme...
Design and Characterization of an Ethosomal Gel Encapsulating Rosehip Extract
Sallustio, Valentina; Farruggia, Giovanna; Di Cagno, Massimiliano Pio; Tzanova, Martina M.; Marto, Joana; Ribeiro, Helena; Gonçalves, LídiaRising environmental awareness drives green consumers to purchase sustainable cosmetics based on natural bioactive compounds. The aim of this study was to deliver Rosa canina L. extract as a botanical ingredient in an anti-aging gel using an eco-friendly approach. Rosehip extract was first characterized in terms of its antioxidant activity through a DPPH assay and ROS reduction test and then encapsulated in eth...
Topical Administration of a Nanoformulation of Chitosan-Hyaluronic Acid-Epoetin...
Silva, Beatriz; Gonçalves, Lídia; Braz, Berta São; Delgado, EsmeraldaThe present work investigates the effects of chitosan-hyaluronic acid-epoetin beta (CS/HA-EPOβ) nanoparticles after topical ocular administration in a rat glaucoma model. Wistar Hannover rats (n = 24) were submitted to a complete ophthalmological examination and electroretinography, followed by glaucoma induction in their right eye on day 1 of the study. Treatment group (T) received CS/HA-EPOβ nanocarriers (n =...
Investigation of the genotoxicity of digested titanium dioxide nanomaterials in...
Vieira, Adriana; Rolo, Dora; Vital, Nádia; Martins, Carla; Assunção, Ricardo; Alvito, Paula; Gonçalves, Lídia; Bettencourt, Ana F.; Silva, Maria JoãoAbout Investigation of the genotoxicity of digested titanium dioxide nanomaterials in human intestinal cells
Analysis of the In Vitro Toxicity of Nanocelluloses in Human Lung Cells as Comp...
Pinto, Fátima V.; Lourenço, Ana Filipa; Pedrosa, Jorge F. S.; Gonçalves, Lídia; Ventura, Célia; Vital, Nádia; Bettencourt, Ana; Fernandes, Susete N.Cellulose micro/nanomaterials (CMNM), comprising cellulose microfibrils (CMF), nanofibrils (CNF), and nanocrystals (CNC), are being recognized as promising bio-nanomaterials due to their natural and renewable source, attractive properties, and potential for applications with industrial and economical value. Thus, it is crucial to investigate their potential toxicity before starting their production at a larger ...