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Efetividade da vacina contra a COVID-19: implementação de estudo de coorte em p...

Gaio, Vânia; Silva, Adriana; Amaral, Palmira; Viana, João Faro; Antunes, Isabel; Gonçalves, João; Gonçalves, Lígia A.; Leite, Pedro; Machado, Ausenda

Num contexto de pandemia, os profissionais de saúde dos hospitais são considerados um grupo de elevado risco para a infeção por SARS-CoV-2 sendo um grupo prioritário para a vacinação. Apesar dos bons resultados da eficácia das vacinas nos ensaios clínicos, são muitos os fatores que podem influenciar a sua eficácia no mundo real (efetividade). Com base num desenho de estudo de coorte prospetivo, desenvolveu-se u...


Population homogeneity for the antibody response to COVID-19 BNT162b2/Comirnaty...

Faro-Viana, João; Bergman, Marie-Louise; Gonçalves, Lígia A.; Duarte, Nadia; Coutinho, Teresa P.; Borges, Patricia C.; Diwo, Christian; Castro, Rute

ABSTRACT: While mRNA vaccines are administrated worldwide in an effort to contain the COVID-19 pandemic, the heterogeneity of the humoral immune response they induce at the population scale remains unclear. Here, in a prospective, longitudinal, cohort-study, including 1245 hospital care workers and 146 nursing home residents scheduled for BNT162b2 vaccination, together covering adult ages from 19 to 99 years, w...


Modeling Malaria Infection and Immunity against Variant Surface Antigens in Prí...

Trovoada, Maria Jesus; Gonçalves, Lígia A.; Marinho, Cláudio R. F.; Turner, Louise; Hviid, Lars; Penha-Gonçalves, Carlos; Gomes, M. Gabriela M.

After remarkable success of vector control campaigns worldwide, concerns about loss of immunity against Plasmodium falciparum due to lack of exposure to the parasite are relevant since an increase of severe cases in less immune individuals is expected. We present a mathematical model to investigate the impact of reducing exposure to the parasite on the immune repertoire against P. falciparum erythrocyte membran...


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