41 documents found, page 1 of 5
Dual-loaded chitosan-based nanoparticles: a novel approach for treating polymic...
Zegre, Miguel; Barros, J.; David, A. B.; Fialho, L.; Ferraz, M. P.; Monteiro, F. J.; Caetano, Liliana Aranha; Gonçalves, L.; Bettencourt, A.Developing innovative approaches to target osteomyelitis caused by polymicrobial infections remains a significant therapeutic challenge. In this study, monodispersed chitosan nanoparticles co-loaded with antibacterial (minocycline) and antifungal (voriconazole) agents were successfully prepared. Minocycline presented higher encapsulation efficiency as compared to voriconazole. Thermostability analysis suggested...
Assessing microplastic pollution in horticultural soils under greenhouse cultiv...
Torre, A.; Gonçalves, L.; Valente, Teresa Maria Fernandes; Henriques, Renato F.; Davim, J.; Ferreira, J. G.; Macedo, J.; Pires, A.; Silva, A. C.[Excerpt] The widespread use of plastic materials in intensive agriculture, including greenhouse covers and irrigation systems, raises increasing concerns regarding microplastic (MP) contamination in terrestrial ecosystems. This study aims to characterize and quantify microplastics in greenhouse agricultural soils in the Minho region of northern Portugal, an area of intensive horticultural production. The main ...
Metaplastic carcinoma of the breast: case series of a single centre
Fialho, M. Pinto; Gonçalves, L.; Ruivo, L.; Gradil, A.; Correia, L.Background & objectives: Metaplastic carcinoma breast cancer (MpBC) is a rare and heterogeneous group of invasive breast carcinomas. Despite some studies and case reports data are currently limited. Our work aims to evaluate the clinicopathological features and the prognosis of MpBC patients. Methods: Retrospective unicentric study of MpBC diagnosed from January 2000 to February 2024. Pathological reports were ...
Poly(D,L-lactic acid) scaffolds as an innovative approach to the treatment of m...
Zegre, Miguel; Barros, J.; Ribeiro, I. A.; Santos, C.; Aranha Caetano, Liliana; Gonçalves, L.; Monteiro, F.; Ferraz, M.; Bettencourt, A.Introduction: The treatment of bacterial joint and bone infections in patients after multiple revision arthroplasties is very challenging. An expanding number of studies report the co-isolation of fungal and bacterial species (such as Candida albicans and Staphylococcus aureus) from polymicrobial biofilm associated with infections related to bone infections. Current investigations establish that local-specific ...
Poly(D,L-lactic acid) scaffolds as an innovative approach to the treatment of m...
Zegre, Miguel; Barros, J.; Ribeiro, I. A.; Santos, C.; Aranha Caetano, Liliana; Gonçalves, L.; Monteiro, F.; Ferraz, M.; Bettencourt, A.Problem - Bone infections associated with polymicrobial biofilm formation; mixed bacterial-fungal biofilm infection; Staphylococcus aureus and Candida albicans most described microbials. Strategy - Local drug delivery scaffolds; development of poly-DL-lactic acid (PDLLA) scaffolds; co-delivery of antibacterial and antifungal drugs; minocycline and voriconazole as model drugs.
Research progress on biodegradable polymeric platforms for targeting antibiotic...
Zegre, Miguel; Poljańska, E.; Caetano, Liliana Aranha; Gonçalves, L.; Bettencourt, A.The treatment of bone infections still involves systemic or local antibiotic therapy in high doses for prolonged periods. Current research focuses on the application of different drug delivery systems to the bone, aiming at a targeted local administration that will decrease the number of drugs used and their toxicity, compared to the systemic route. The gold standard in clinical practice is currently poly(methy...
Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio are not predict...
Pinho, I. Soares de; Barroso, T.; Trabulo, C.; Campoa, E.; Patel, V.; Gonçalves, L.; Araújo, J.; Monteiro, C.; Ferreira, A.; Machado, B.; Dâmaso, S.Pathological complete response (pCR) to neoadjuvant chemotherapy (NAChT) has been validated as a predictor of long-term survival in breast cancer (BC), especially in triple-negative breast cancer (TNBC)
Chitosan-based nanoparticles as a dual drug delivery system directed to bone in...
Falcão, J.; Zegre, Miguel; Bastron, S.; Ribeiro, I. A.; Gonçalves, L.; Bettencourt, A.Osteomyelitis treatment is usually described as a challenging issue, mainly because of the necessity of high levels of antimicrobials employed for extended periods, since the infection is characterized by poor blood circulation. Innovative options of targeted and controlled drug delivery systems, presenting sustained antimicrobial release, high concentrations of drugs in the infected areas, low concentrations i...
Chitosan nanoparticles loaded with minocycline targeting osteomyelitis
Zegre, Miguel; Bastron, S.; Ribeiro, I. A.; Caetano, Liliana Aranha; Gonçalves, L.; Bettencourt, A.Effective control of osteomyelitis (bone infection) with reduced toxicity is a current challenge. Targeted and controlled drug delivery systems allow: decreased toxicity, upgraded drug targeting, and improved therapeutic effect. Strategy: a) Innovative chitosan nanoparticulate system: nanoparticles loaded with minocycline (antibacterial), and alternative as a local delivery system; b) Nanoparticles and biofilms...
Poly(DL-lactic acid) scaffolds as a bone targeting platform for the co-delivery...
Zegre, Miguel; Barros, J.; Ribeiro, I. A.; Santos, C; Caetano, Liliana Aranha; Gonçalves, L.; Monteiro, F. J.; Ferraz, M. P.; Bettencourt, A.New strategies for the treatment of polymicrobial bone infections are required. In this study, the co-delivery of two antimicrobials by poly(D,L-lactic acid) (PDLLA) scaffolds was investigated in a polymicrobial biofilm model. PDLLA scaffolds were prepared by solvent casting/particulate leaching methodology, incorporating minocycline and voriconazole as clinically relevant antimicrobial agents. The scaffolds pr...